Cellular therapy for ocular degeneration
Compositions and methods applicable to cell-based or regenerative therapy for ophthalmic diseases and disorders comprising mesenchymal stem cells, particularly those characterized by the expression of at least one of the following surface markers: CD29, CD44, CD105 or CD166, and the lack of expression of at least one of CD14, CD34 or CD45.
1. A method of treating a patient having retinitis pigmentosa, the method comprising administering to the patient mesenchymal stem cells in an amount effective to treat the retinitis pigmentosa, wherein the mesenchymal stem cells are characterized by the expression of CD105, and the lack of expression of CD34, and wherein the mesenchymal stem cells promote the survival of ocular cells, or the formation of photoreceptors from ocular cells in situ, but the mesenchymal stem cells do not form structures similar to the photoreceptor layer and do not express a photoreceptor-specific marker; or do not differentiate into photoreceptors themselves.
2. The method of claim 1 , wherein the cells are administered to the surface of an eye.
3. The method of claim 1 , wherein the cells are administered to the interior of an eye.
4. The method of claim 3 , wherein the cells are administered through a cannula or from a device implanted in the patient's body within or in proximity to the eye.
5. The method of claim 3 , wherein the cells are administered by implantation of a three dimensional matrix or support containing the cells.
6. The method of claim 3 , wherein the method comprises administration of a pharmaceutical composition comprising the cells and a pharmaceutically acceptable carrier.
7. The method of claim 6 , wherein the pharmaceutical composition is formulated for administration to the surface of an eye.
8. The method of claim 6 , wherein the pharmaceutical composition is formulated for administration to the interior of an eye.