Compositions and method for hair loss prevention
The invention encompasses a formulation for hair loss prevention comprising a mixture of water and at least one nonpolar aprotic organic solvent and at least one hair loss preventive ingredient known to inhibit the hormonal mechanism underlying androgenetic hair loss and methods of using the same.
1. A method of treating hair loss comprising applying a hair loss treating formulation in a therapeutically sufficient amount to an area of skin, wherein the formulation comprises at least one hair loss treating ingredient known to inhibit the hormonal mechanism underlying androgentic hair loss, a C 6 -C 14 dicarboxylic acid, and a mixture of water and at least one aprotic organic solvent, wherein the mixture of water and aprotic organic solvent is capable of solubilizing sebum and allowing the at least one ingredient to reach the skin and/or hair follicle, and wherein the aprotic organic solvent is present in an amount of 60% to 90% by weight of the formulation and the water is present in an amount of 2% to 20% by weight of the formulation.
2. The method according to claim 1 , wherein the at least one aprotic organic solvent is selected from the group consisting of esters, aldehydes, ketones and mixtures thereof.
3. The method according to claim 2 , wherein the ester is methyl formate, ethyl formate, propyl formate, methyl acetate, ethyl acetate, propyl acetate, methyl propionate, ethyl propionate or propyl prionate.
4. The method according to claim 2 , wherein the aldehyde is acetaldehyde, propionaldehyde, or butyraldehyde.
5. The method according to claim 2 , wherein the ketone is acetone, butanone, pentanone, ethylisopropyl ketone, or methylisobutyl ketone.
6. The method according, to claim 2 , wherein the at least one aprotic organic solvent is C 2 -C 6 ester, C 2 -C 4 aldehyde, or a C 3 -C 6 ketone.
7. The method according to claim 1 , wherein the C 6 -C 14 dicarboxylic acid is pimelic acid, suberic acid, azelaic acid, sebacic acid, undecanedioic acid, dodecanedioic acid or brassylic acid.
8. The method according to claim 7 , wherein the C 4 -C 14 dicarboxylic acid is azelaic acid.
9. The method according to claim 1 , wherein the C 6 -C 14 dicarboxylic acid is present in an amount of about 2% to 30% by weight of the formulation.
10. The method according to claim 1 , wherein the formulation further comprises a herbal extract.
11. The method according to claim 1 , wherein the formulation further comprises at least one antifungal compound.
12. The method according to claim 11 , wherein the at least one antifungal compound is zinc pyrithione, tar, selenium sulphide, ketoconazole, or tea tree oil.
13. The method according to claim 1 , wherein the formulation further comprises finasteride, minoxidil, tretinoin or combinations thereof.
14. The method according to claim 13 , wherein the finasteride, minoxidil, or tretinoin is present in an amount of about 0.001% to 5% by weight of the formulation.
15. The method according to claim 1 , wherein the formulation further comprises minoxidil.
16. The method according to claim 1 , wherein said formulation comprises acetone at 76% by weight of the formulation, azelaic acid at 17% by weight of the formulation, zinc pyrithione at 0.05% by weight of the formulation, minoxidil at 2% by weight of the formulation and finasteride at 0.2% by weight of the formulation.