Methods for improving muscle strength
The present invention relates to methods for improving muscle strength and treating muscular dystrophy.
1. A method for increasing muscle strength in a subject, the method comprising administering rapamycin-loaded nanoparticles to a subject in need of increased muscle strength.
2. The method of claim 1 , wherein the subject has muscular dystrophy.
3. The method of claim 1 , wherein the subject is suffering from muscle weakness resulting from aging.
4. The method of claim 1 , wherein the subject is suffering from muscle weakness resulting from a traumatic injury or surgery.
5. The method for claim 1 , wherein the administration of rapamycin-loaded nanoparticles induces autophagy of muscle cells.
6. The method for claim 1 , wherein the administration of rapamycin-loaded nanoparticles attenuates muscle destruction.
7. The method for claim 1 , wherein the rapamycin-loaded nanoparticles are administered intravenously.
8. The method for claim 1 , wherein the rapamycin-loaded nanoparticles comprise between about 0.1 and 0.5% rapamycin.
9. The method for claim 1 , wherein the rapamycin-loaded nanoparticles are administered at least once a week.
10. The method for claim 1 , wherein 1 mL/kg of the rapamycin-loaded nanoparticles are administered at least once a week.
11. A method for attenuating muscle destruction in a subject, the method comprising administering rapamycin-loaded nanoparticles to a subject experiencing muscle destruction.
12. The method for claim 11 , wherein the administration of rapamycin-loaded nanoparticles induces autophagy.
13. The method for claim 11 , wherein the rapamycin-loaded nanoparticles are administered intravenously.
14. The method for claim 11 , wherein the rapamycin-loaded nanoparticles comprise between about 0.1 and 0.5% rapamycin.
15. The method for claim 11 , wherein the rapamycin-loaded nanoparticles are administered at least once a week.
16. A method for inducing autophagy in the muscle cells of a subject, the method comprising administering rapamycin-loaded nanoparticles so that autophagy is increased in the muscle cells of the subject.
17. The method for claim 16 , wherein the administration of rapamycin-loaded nanoparticles attenuates muscle destruction.
18. The method for claim 16 , wherein the rapamycin-loaded nanoparticles are administered intravenously.
19. The method for claim 16 , wherein the rapamycin-loaded nanoparticles comprise between about 0.1 and 0.5% rapamycin.
20. The method for claim 16 , wherein the rapamycin-loaded nanoparticles are administered at least once a week.