Granted Patent
B2
US 9,102,651 · App. 13/214,937 · Granted Aug 11, 2015
Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
Inventors:
Daria Mochly-Rosen (Menlo Park, CA); Che-Hong Chen (Fremont, CA); Xiaohu Ouyang (Fremont, CA)
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Abstract
The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2.
Claims (5)
1. A compound of one of the following formulas:
2. A pharmaceutical composition comprising:
(a) a compound of claim 1 ; and
(b) a pharmaceutically acceptable excipient.
3. A compound of the formula:
Assignments (2)
CONFIRMATORY LICENSE
Recorded Jul 2, 2015
From: STANFORD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 036047/0157 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 29, 2012
From: MOCHLY-ROSEN, DARIA; CHEN, CHE-HONG; OUYANG, XIAOHU
To: THE BOARD OF TRUSTEES LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 027785/0737 →
Continuity (3)
Provisional Application
60905963
· Mar 8, 2007