Natriuretic polypeptides
View Patent ↗This document provides methods and materials related to natriuretic polypeptides and the use of natriuretic polypeptides to treat cardiovascular and/or renal conditions. For example, chimeric polypeptides having at least one amino acid segment (e.g., N-terminus tail, ring structure, C-terminus tail, or a combination thereof) of a natriuretic peptide (e.g., ANP, BNP, CNP, URO, or DNP) and an amino acid segment of an angiotensin polypeptide (e.g., Ang-(1-7)) are provided.
1. A polypeptide from 24 to 55 amino acid residues in length, wherein said polypeptide comprises, in an order from amino terminus to carboxy terminus:
(a) the sequence set forth in SEQ ID NO:1 or the sequence set forth in SEQ ID NO: 1 with no more than two additions, deletions, or substitutions,
(b) the sequence set forth in SEQ ID NO:5 or the sequence set forth in SEQ ID NO:5 with no more than two additions, deletions, or substitutions, and
(c) the sequence set forth in SEQ ID NO:13 or the sequence set forth in SEQ ID NO:13 with no more than two additions, deletions, or substitutions.
2. The polypeptide of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:1.
3. The polypeptide of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:5.
4. The polypeptide of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:13.
5. The polypeptide of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:61 with no more than two additions, deletions, or substitutions.
6. The polypeptide of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:61.
7. The polypeptide of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:5 with no more than one addition, deletion, or substitution.