Treatment of sepsis and inflammation with alpha
View Patent ↗Provided are methods for treating a mammal undergoing sepsis, or at risk for sepsis. Also provided are methods of preventing or treating a physiological effect of sepsis in a mammal. Additionally provided are methods of inhibiting an inflammatory response in a mammal. Further provided is the use of an α 2A -adrenergic antagonist for the manufacture of a medicament for preventing or treating a physiologic effect of sepsis in a mammal, and the use of an α 2A -adrenergic antagonist for the treatment of a mammal having sepsis or at risk for sepsis.
1. A method of attenuating sepsis in a mammal, the method comprising administering to the mammal an amount of an α 2A -specific-adrenergic antagonist compound that is BRL-44408, or a salt thereof, which attenuates sepsis.
2. The method of claim 1 , wherein the α 2A -specific-adrenergic-antagonist compound is BRL-44408 maleate.
3. The method of claim 1 , further comprising treating the mammal with an amount of adrenomedullin, adrenomedullin binding protein, activated protein C, or milk fat globule epidermal growth factor-factor VIII that can reduce a physiological effect of the sepsis.
4. The method of claim 1 , wherein the mammal is a human.