Implantable system enabling responsive therapy for pain
An implantable neurostimulator system for treating pain includes scheduled and responsive therapy capabilities including responsive stimulation applied to the brain and peripheral sections of the nervous system. Methods for treating chronic nociceptive, neuropathic, and psychogenic pain employ an inventive system to advantageously reduce multiple symptoms and components of pain and to address underlying causes of pain.
1. An implantable system for treating pain in a patient, the system comprising:
a master module configured to be implanted at or near a first location, the master module including:
a master communications subsystem,
a master therapy subsystem, and
a master detection subsystem configured to identify a first pain signature based at least in part on signals sensed at or near a first detection location, and to initiate application of a therapy in response to confirmation of a pain signature; and
a remote module configured to be implanted at or near a second location, the remote module including:
a remote communications systems, and
at least one of a remote therapy subsystem, and a remote detection subsystem, the remote detection subsystem configured to: obtain information corresponding to one or more of signals sensed at or near a second detection location, and/or to identify a second pain signature based on signals sensed at or near the second detection location.
2. The system of claim 1 , wherein the master detection subsystem is configured to initiate application of a therapy through the master therapy subsystem.
3. The system of claim 2 , further comprising a therapy output configured to be implanted at or near a first therapy location and coupled to the master therapy subsystem, the therapy output being configured to deliver the therapy.
4. The system of claim 3 , wherein the therapy output comprises an electrical stimulation electrode, a magnetic stimulator, a transcranial magnetic stimulator, an optical stimulator, a catheter coupled to a drug dispenser, or a thermal conductor coupled to a thermal stimulator.
5. The system of claim 1 , wherein the master detection subsystem is configured to initiate application of a therapy through the remote therapy subsystem, the initiation implemented over a communication link between the master communications subsystem and the remote communications subsystem.
6. The system of claim 5 , further comprising a therapy output configured to be implanted at or near a second therapy location and coupled to the remote therapy subsystem, the therapy output being configured to deliver the therapy.
7. The system of claim 1 , wherein the remote detection subsystem is configured to transmit a message to the master detection subsystem over a communication link between the master communications subsystem and the remote communications subsystem, the message including information corresponding to one or more of: parameters of signals sensed at or near the second detection location, or an indication of an identified second pain signature.
8. The system of claim 7 , wherein the master detection subsystem is configured to confirm a pain signature based on both the signals sensed at or near the first detection location and the parameters of signals sensed at or near the second detection location.
9. The system of claim 7 , wherein the master detection subsystem is configured to confirm a pain signature when both of a first pain signature and a second pain signature are identified.
10. The system of claim 7 , wherein the master detection subsystem is configured to confirm a pain signature when either one of a first pain signature or a second pain signature is identified.
11. The system of claim 1 , wherein the first detection location and the second detection location are remote from each other.
12. The system of claim 1 , wherein the first therapy location and the second therapy location are remote from each other.
13. The system of claim 1 , wherein each of the first pain signature and the second pain signature comprise at least one of an electrical burst, an electrographic pattern indicative of activation, an electrographic pattern indicative of inhibition, and an oscillating signal.
14. An implantable system for treating pain in a patient, the system comprising:
a master module configured to be implanted at or near a first location, the master module including:
a master communications subsystem,
a master therapy subsystem, and
a master detection subsystem configured to identify a first pain signature based at least in part on signals sensed at or near a first detection location, and to initiate application of a therapy in response to confirmation of a pain signature; and
a remote module configured to be implanted at or near a second location, the remote module including:
a remote communications systems, and
at least one of a remote therapy subsystem, and a remote detection subsystem, the remote detection subsystem configured to: obtain information corresponding to one or more of signals sensed at or near a second detection location, and/or to identify a second pain signature based on signals sensed at or near the second detection location,
wherein each of the master detection subsystem and the remote detection subsystem processes respective sensed signals to identify a respective first pain signature and a second pain signature by being further configured to:
obtain a measure of spectral energy in the respective sensed signals; and
compare the measure to a respective criterion indicative of a pain signature.
15. An implantable system for treating pain in a patient, the system comprising:
a master module configured to be implanted at or near a first location, the master module including:
a master communications subsystem,
a master therapy subsystem, and
a master detection subsystem configured to identify a first pain signature based at least in part on signals sensed at or near a first detection location, and to initiate application of a therapy in response to confirmation of a pain signature; and
a remote module configured to be implanted at or near a second location, the remote module including:
a remote communications systems, and
at least one of a remote therapy subsystem, and a remote detection subsystem, the remote detection subsystem configured to: obtain information corresponding to one or more of signals sensed at or near a second detection location, and/or to identify a second pain signature based on signals sensed at or near the second detection location,
wherein the master detection subsystem is configured to confirm a pain signature when:
both of a first pain signature and a second pain signature are identified, or
either one of a first pain signature or a second pain signature is identified.