IP Library › Granted Patent US 9,115,186
Granted Patent B2
US 9,115,186 · App. 12/702,209 · Granted Aug 25, 2015

Stabilized trimeric HIV-1 gp41 fusion polypeptides comprising the N-terminal heptad repeat (NHR) and foldon (FD) trimerization motif

Inventors: Shibo Jiang (Fresh Meadows, NY); Zhi Qi (Corona, NY); Xi Chen (Elmhurst, NY); Chungen Pan (Guangzho, CN)
Assignee: New York Blood Center
C07K14/005A61K38/00C07K2319/735C12N2740/16111C12N2740/16122
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Quick Facts
Patent No.
US 9,115,186
App. No.
12/702,209
Granted
Aug 25, 2015
Kind
B2
Abstract

Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.

Claims (4)

1. A pharmaceutical composition comprising a trimeric polypeptide, wherein said trimeric polypeptide comprises three polypeptide monomers, each polypeptide monomer consisting of a fusion peptide consisting of the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) of the transmembrane glycoprotein gp41 of human immunodeficiency virus (HIV) fused to a foldon trimerization motif, wherein said NHR is N28, and wherein said foldon trimerization motif sequence is fused to the C-terminus of said NHR.

2. The pharmaceutical composition of claim 1 wherein said polypeptide monomer is produced by recombinant DNA technology.

3. The pharmaceutical composition of claim 1 wherein said polypeptide monomer comprises the amino acid sequence of SEQ ID NO. 6.

4. The pharmaceutical composition of claim 1 wherein said polypeptide monomer comprises the amino acid sequence of SEQ ID NO. 13.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jul 5, 2017
From: NEW YORK BLOOD CENTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 043084/0837 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 11, 2014
From: JIANG, SHIBO; QI, ZHI; CHEN, XI; PAN, CHUNGEN
To: NEW YORK BLOOD CENTER
Reel/Frame 033077/0511 →
Continuity (2)
Provisional Application 61151110 · Feb 9, 2009
Related Publication 20100204120A1 · Aug 12, 2010