Tetracyclic compound

1. A compound or salt or solvate thereof represented by Formula (I):

wherein,

A 1 , A 2 , A 3 , A 4 , A 7 , A 8 , A 9 and A 10 all represent C;

A 5 is selected from NR 5 , O and S;

R 1 and R 10 each independently represent [1] a hydrogen atom, [2] a cyano group, [3] a halogen atom or [4] a 4- to 10-membered heterocycloalkyl group which may be substituted by 4- to 10-membered heterocycloalkyl group(s);

R 2 is selected from the group consisting of:

(1) a hydrogen atom,

(2) a C 1-8 alkyl group,

(3) a C 2-8 alkenyl group,

(4) a C 2-8 alkynyl group,

(5) a cyano group,

(6) a halogen atom,

(7) a (C 1-8 alkyl)-amino group which may be substituted by C 1-8 alkylsulfonyl group(s),

m2: 0˜2, and

(8) a nitro group;

R 3 is selected from the group consisting of:

(1) a hydrogen atom,

(2) a C 1-8 alkyl group which may be substituted by [1] halogen atom(s), [2] hydroxy group(s) or [3] C 1-8 alkoxy group(s),

(3) a C 6-10 aryl group,

(4) a cyano group,

(5) a C 1-8 alkanoyl group which may be substituted by C 6-10 aryl group(s),

(6) a (C 1-8 alkyl) m3a -aminocarbonyl group which may be substituted by one or more R 3A ,

R 3A : [1] a C 6-10 aryl group, [2] a C 1-8 alkoxy group, [3] a 5- to 14-membered heteroaryl group, or [4] a C 6-10 arylsulfonyl group,

m3a: 0˜2,

(7) a hydroxycarbonyl group,

(8) a C 1-8 alkoxycarbonyl group which may be substituted by [1] hydroxy group(s) or [2] C 1-8 alkoxy group(s),

(9) a halogen atom,

(10) a (C 1-8 alkyl) m3b -amino group which may be substituted by C 6-10 aryl group(s),

m3b: 0˜2,

(11) a C 1-8 alkylcarbonyl (C 0-8 alkyl)amino group which may be substituted by [1] C 6-10 aryl group(s) or [2] C 6-10 aryloxy group(s),

(12) a C 6-10 arylcarbonyl (C 0-8 alkyl)amino group which may be substituted by C 1-8 alkyl group(s) which may be substituted by halogen atom(s),

(13) a (C 1-8 alkyl) m3c -aminocarbonyl (C 0-8 alkyl)amino group which may be substituted by C 6-10 aryl group(s),

m3c: 0˜2,

(14) a nitro group,

(15) a hydroxy group,

(16) a C 1-8 alkoxy group which may be substituted by one or more R 3B ,

R 3B : [1] a hydroxy group, [2] a C 1-8 alkoxy group, [3] a C 6-10 aryl (C 0-8 alkyl)aminocarbonyl group, [4] a (C 1-8 alkyl) m3d -amino group, or [5] a halogen atom,

m3 d: 0˜2,

(17) a 4- to 10-membered heterocycloalkyloxy group,

(18) a 5- to 14-membered heteroaryloxy group,

(19) a (C 1-8 alkyl) m3e -aminocarbonyloxy group which may be substituted by C 6-10 aryl group(s)

m3e: 0˜2,

(20) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group,

(21) a C 1-8 alkylsulfonyloxy group which may be substituted by halogen atom(s),

(22) a C 1-8 alkylthio group,

(23) a C 1-8 alkylsulfonyl group which may be substituted by C 6-10 aryl group(s),

(24) a 5- to 14-membered heteroaryl group which may be substituted by C 1-8 alkyl group(s) which may be substituted by C 1-8 alkoxy group(s),

(25) a C 1-8 alkoxycarbonyl (C 0-8 alkyl)amino group which may be substituted by C 1-8 alkoxy group(s),

(26) a C 6-10 aryloxycarbonyl (C 0-8 alkyl)amino group which may be substituted by C 1-8 alkyl group(s) which may be substituted by halogen atom(s),

(27) a C 6-10 aryl (C 0-8 alkyl)aminocarbonyl (C 0-8 alkyl)amino group which may be substituted by one or more R 3C ,

R 3C : [1] a C 1-8 alkyl group which may be substituted by halogen atom(s), or [2] a C 1-8 alkoxy group,

(28) a C 3-8 cycloalkyl (C 0-8 alkyl)aminocarbonyloxy group, and

(29) a C 6-10 aryl (C 0-8 alkyl)aminocarbonyloxy group which may be substituted by substituent(s) selected from the group consisting of [1] a C 1-8 alkyl group and [2] a C 1-8 alkoxy group;

R 4 is selected from the group consisting of:

(1) a hydrogen atom,

(2) a C 1-8 alkyl group which may be substituted by halogen atom(s),

(3) a C 2-8 alkenyl group,

(4) a C 2-8 alkynyl group,

(5) a C 3-8 cycloalkyl group,

(6) a cyano group,

(7) an aminocarbonyl group,

(8) a (C 1-8 alkyl) m4a -aminocarbonyl group,

m4a: 1˜2,

(9) a hydroxycarbonyl group,

(10) a C 1-8 alkoxycarbonyl group,

(11) a halogen atom,

(12) a (C 1-8 alkyl) m4b -amino group,

m4b: 0˜2,

(13) a hydroxy group, and

(14) a C 1-8 alkoxy group which may be substituted by hydroxy group(s);

R 5 is selected from the group consisting of:

(1) a hydrogen atom,

(2) a C 1-8 alkyl group which may be substituted by one or more R 5A ,

R 5A : [1] a hydroxycarbonyl group, [2] a C 1-8 alkoxycarbonyl group, [3] a hydroxy group, [4] a C 1-8 alkoxy group, [5] a (C 1-8 alkyl) m5 -amino group, [6] a C 6-10 aryl group, or [7] a C 1-8 alkylthio group,

m5: 0˜2,

(3) a C 2-8 alkenyl group,

(4) a C 2-8 alkynyl group,

(5) a C 3-8 cycloalkyl group, and

(6) a C 1-8 alkylsulfonyl group;

R 6 and R 6′ are each independently selected from the group consisting of:

(1) a C 1-8 alkyl group which may be substituted by halogen atom(s),

(2) a C 2-8 alkenyl group, and

(3) a C 2-8 alkynyl group; or

R 6 and R 6′ are taken together with the carbon atoms to which they are bound to form:

(4) a C 3-8 cycloalkyl group, or

(5) a 4- to 10-membered heterocycloalkyl group which may be substituted by C 1-8 alkyl C 6-10 aryl sulfonyl group(s) which may be substituted by C 1-8 alkyl group(s);

R 7 is selected from the group consisting of:

(1) a hydrogen atom,

(2) a halogen atom,

(3) a C 1-8 alkoxy group which may be substituted by one or more R 7A ,

R 7A : [1] a (C 1-8 alkyl) m7a -amino group, [2] a hydroxy, [3] a 4- to 10-membered heterocycloalkyl group which may be substituted by C 1-8 alkyl group(s),

m7a: 0˜2,

(4) a C 1-8 alkylsulfonyl group,

(5) a nitro group, and

(6) a hydroxyl group;

R 8 is selected from the group consisting of:

(1) a hydrogen atom,

(2) a C 1-8 alkyl group which may be substituted by one or more R 8A ,

R 8A : [1] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R 8A1 , [2] a (C 1-8 alkyl) m8a -amino group which may be substituted by a halogen atom, or [3] a hydroxy group,

m8a:0˜2,

R 8A1 : [1] a C 1-8 alkyl group, [2] a C 1-8 alkylsulfonyl group, [3] a (C 1-8 alkyl) m8b -aminosulfonyl group, [4] an oxo group, [5] a C 1-8 alkoxycarbonyl, or [6] a C 1-8 alkoxycarbonyl (C 0-8 alkyl)aminosulfonyl,

m8b: 0˜2,

(3) a C 2-8 alkenyl group,

(4) a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R 8B ,

R 8B :

<1> a C 1-8 alkyl group which may be substituted by one or more R 8B1 ,

<2> a C 2-8 alkeynyl group,

<3> a C 2-8 alkynyl group,

<4> a C 3-8 cycloalkyl group which may be substituted by [1] cyano group(s) or [2] C 1-8 alkyl group(s),

<5> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R 8B2 ,

<6> a C 1-8 alkoxy group which may be substituted by substituent(s) selected from the group consisting of [1] a C 1-8 alkoxy group and [2] a C 3-8 cycloalkyl group,

<7> a C 1-8 alkoxycarbonyl group,

<8> a C 1-8 alkylsulfonyl group,

<9> a 5- to 14-membered heteroarylsulfonyl group,

<10> an oxo group,

<11> a cyano group,

<12> a C 1-8 alkanoyl group which may be substituted by one or more R 8B3 ,

<13> a C 3-8 cycloalkylcarbonyl group,

<14> a (C 1-8 alkyl) m8c -aminosulfonyl group,

<15> a C 1-8 alkylsulfonyl (C 0-8 alkyl)amino group,

<16> a (C 1-8 alkyl) m8d -amino group which may be substituted by one or more R 8B4 ,

<17> a hydroxy group,

<18> a (C 1-8 alkyl) m8e -aminocarbonyl group, or

<19> a C 1-8 alkoxycarbonyl (C 0-8 alkyl)amino group

m8c: 0˜2

m8d: 0˜2

m8e: 0˜2

R 8B1 : [1] a C 3-8 cycloalkyl group, [2] a hydroxy group, or [3] a C 1-8 alkoxy group(s),

R 8B2 : [1] a halogen atom, [2] a C 1-8 alkyl group, [3] an oxo group, [4] a hydroxy group, or [5] a deuterium atom,

R 8B3 : a (C 1-8 alkyl) m8f -amino group,

m8f: 0˜2,

R 8B4 : [1] a C 3-8 cycloalkyl group, or [2] a hydroxy group,

(5) a 5- to 14-membered heteroaryl group which may be substituted by a C 1-8 alkyl group,

(6) a (C 1-8 alkyl) m8g -aminocarbonyl group which may be substituted by one or more R 8C ,

m8g: 0˜2,

R 8C : [1] a hydroxy group, [2] a (C 1-8 alkyl) m8h -amino group which may be substituted by substituent(s) selected from the group consisting of <1> a (C 1-8 alkyl) m8i -aminosulfonyl group, <2> a C 1-8 alkylsulfonyl group, <3> a C 1-8 alkoxycarbonyl group and <4> a C 1-8 alkoxycarbonyl(C 0-8 alkyl)aminosulfonyl group, [3] a C 1-8 alkylsulfonyl group, or [4] a C 1-8 alkoxy group which may be substituted by a hydroxy group,

m8h: 0˜2,

m8i: 0˜2,

(7) a 4- to 10-membered heterocycloalkyl (C 0-8 alkyl)aminocarbonyl group which may be substituted by oxo group(s),

(8) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by one or more R 8D ,

R 8D : [1] a C 1-8 alkyl group which may be substituted by one or more R 8D1 , [2] a hydroxy group, [3] a C 1-8 alkylsulfonyl group, or [4] a C 1-8 alkoxycarbonyl group,

R 8D1 : [1] a hydroxy group, or [2] a C 1-8 alkoxy group,

(9) a hydroxycarbonyl group,

(10) a C 0-8 alkoxy (C 0-8 alkyl)aminocarbonyl group which may be substituted by hydroxy group(s),

(11) a halogen atom,

(12) a (C 1-8 alkyl) m8j -amino group which may be substituted by one or more R 8H ,

m8j: 0˜2,

R 8H : [1] a hydroxy group, or [2] a 4- to 10-membered heterocycloalkyl group,

(13) a hydroxyl group,

(14) a C 1-8 alkoxy group which may be substituted by one or more R 8E ,

R 8E :

<1> a hydroxy group,

<2> halogen atom,

<3> a hydroxycarbonyl group,

<4> a C 1-8 alkoxycarbonyl group,

<5> a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by one or more R 8E1 ,

<6> a (C 1-8 alkyl) m8k1 -amino group which may be substituted by one or more R 8E2 ,

m8k1: 0˜2,

<7> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R 8E3 ,

<8> a 5- to 14-membered heteroaryl group,

<9> a (C 1-8 alkyl) m8k2 -aminocarbonyl group which may be substituted by one or more R 8E6 ,

m8k2: 0˜2,

<10> a C 1-8 alkoxy group which may be substituted by one or more R 8E7 ,

<11> a C 1-8 alkylthio group,

<12> a C 1-8 alkylsulfinyl group,

<13> a C 1-8 alkylsulfonyl group,

R 8E1 :

<1> a C 1-8 alkoxycarbonyl group,

<2> a C 1-8 alkanoyl group,

<3> a C 1-8 alkylsulfonyl group,

<4> a (C 1-8 alkyl) m8k3 -aminosulfonyl group,

m8k3: 0˜2, or

<5> a 4- to 10-membered heterocycloalkyl group,

R 8E2 :

<1> a hydroxy group,

<2> a C 1-8 alkoxycarbonyl group which may be substituted by halogen atom(s),

<3> a C 3-8 cycloalkyl group which may be substituted by C 1-8 alkyl group(s) which may be substituted by hydroxy group(s),

<4> a C 1-8 alkanoyl group which may be substituted by substituent(s) selected from the group consisting of [1] a (C 1-8 alkyl) m8k4 -amino group and [2] a halogen atom(s),

m8k4: 0˜2,

<5> a (C 1-8 alkyl) m8k5 -aminocarbonyl group,

m8k5: 0˜2,

<6> a C 1-8 alkylsulfonyl group,

<7> a 4- to 10-membered nitrogen-containing heterocycloalkylsulfonyl group which may be substituted by C 1-8 alkyl group(s),

<8> a (C 1-8 alkyl) m8k6 -aminosulfonyl group which may be substituted by C 1-8 alkoxycarbonyl group(s),

m8k6: 0˜2, or

R 8E3 :

<1> a C 1-8 alkyl group which may be substituted by substituent(s) selected from the group consisting of [1] a hydroxy group and [2] a C 1-8 alkylcarbonyloxy group,

<2> a C 1-8 alkylcarbonyloxy group,

<3> a hydroxy group,

<4> a C 3-8 cycloalkyl group,

<5> a C 1-8 alkoxy group,

<6> a C 1-8 alkoxycarbonyl group,

<7> a C 1-8 alkylsulfonyl group,

<8> a (C 1-8 alkyl) m8k8 -aminocarbonyl group

m8k8: 0˜2,

<9> a C 1-8 alkanoyl group which may be substituted by hydroxy group(s),

<10> an oxo group, or

<11> a 4- to 10-membered heterocycloalkyl group which may be substituted by substituent(s) selected from the group consisting of [1] a C 1-8 alkanoyl group, [2] a C 1-8 alkoxycarbonyl group and [3] a C 1-8 alkylsulfonyl group,

R 8E6 :

<1> a C 2-8 alkenylcarbonyloxy group,

<2> a hydroxy group,

<3> a cyano group,

<4> a (C 1-8 alkyl) m8k9 -amino group which may be substituted by hydroxy group(s)

m8k9: 0˜2,

<5> a C 1-8 alkoxy group which may be substituted by hydroxy group(s),

<6> a C 1-8 alkylcarbonyloxy group,

<7> a 4- to 10-membered heterocycloalkyl group which may be substituted by C 1-8 alkyl group(s), or

<8> a 5- to 14-membered heteroaryl group,

R 8E7 :

<1> a hydroxy group, or

<2> a C 1-8 alkoxy group which may be substituted by hydroxy group(s),

(15) a 4- to 10-membered heterocycloalkyloxy group which may be substituted by one or more R 8F ,

R 8F :

<1> a C 1-8 alkyl group which may be substituted by one or more R 8F1 ,

<2> a C 3-8 cycloalkyl group,

<3> a C 1-8 alkanoyl group which may be substituted by halogen atom(s),

<4> a C 1-8 alkylcarbonyloxy group,

<5> a C 1-8 alkoxycarbonyl group,

<6> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R 8F2 ,

<7> a C 1-8 alkyl sulfonyl group,

<8> a hydroxy group, or

[9] a C 6-10 aryl group,

R 8F1 : [1] a hydroxy group, [2] a C 1-8 alkoxy group, or [3] a halogen atom,

R 8F2 : [1] a 4- to 10-membered heterocycloalkyl group, [2] a C 1-8 alkoxycarbonyl group, or [3] a C 1-8 alkylsulfonyl group,

(16) a 5- to 14-membered heteroaryloxy group,

(17) a 4- to 10-membered heterocycloalkylcarbonyloxy group,

(18) a (C 1-8 alkyl) m8l1 -aminosulfonyloxy group,

m8l1: 0˜2,

(19) a C 1-8 alkyl thio group which may be substituted by [1] (C 1-8 alkyl) m8l2 -amino group(s), [2] hydroxy group(s) or [3] hydroxycarbonyl group(s),

m8l2: 0˜2,

(20) a C 1-8 alkylsulfonyl group which may be substituted by one or more R 8G ,

R 8G : [1] a hydroxycarbonyl group, [2] a hydroxy group, or [3] a (C 1-8 alkyl) m8l3 -amino group,

m8l3: 0˜2,

(21) a 4- to 10-membered nitrogen-containing heterocycloalkylsulfonyloxy group which may be substituted by C 1-8 alkyl group(s),

(22) a C 2-8 alkenyloxy group, and

(23) a C 1-8 alkylsulfonyloxy group which may be substituted by halogen atom(s);

R 9 is selected from the group consisting of:

(1) a hydrogen atom,

(2) a C 1-8 alkyl group which may be substituted by one or more R 9A ,

R 9A : [1] a C 3-8 cycloalkyl group, [2] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R 9A1 , [3] a hydroxy group, [4] a C 1-8 alkoxy group, or [5] a hydroxycarbonyl group,

R 9A1 : [1] a C 1-8 alkyl group, [2] a C 3-8 cycloalkyl group, or [3] a 4- to 10-membered heterocycloalkyl group,

(3) a C 2-8 alkenyl group which may be substituted by one or more R 9B ,

R 9B : [1] a (C 1-8 alkyl) m9a -amino group, [2] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more group R 9B1 ,

R 9B1 : [1] a C 3-8 cycloalkyl group, or [2] a 4- to 10-membered heterocycloalkyl group,

m9a: 0˜2,

(4) a C 2-8 alkynyl group which may be substituted by one or more R 9C ,

R 9C : [1] a C 1-8 alkoxy group, [2] a (C 1-8 alkyl) m9b -amino group which may be substituted by C 6-10 aryl group(s), [3] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R 9C1 , [4] a C 3-8 cycloalkyl group, [5] a hydroxy group, [6] a hydroxycarbonyl group, or [7] a C 1-8 alkyloxycarbonyl group,

m9b: 0˜2,

R 9C1 : [1] a C 3-8 cycloalkyl group, [2] a 4- to 10-membered heterocycloalkyl group, or [3] an oxo group,

(5) a C 3-8 cycloalkyl group,

(6) a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R 9D ,

R 9D : [1] a C 1-8 alkyl group which may be substituted by 4- to 10-membered heterocycloalkyl group(s), [2] a C 3-8 cycloalkyl group, [3] a 4- to 10-membered heterocycloalkyl group, or [4] a C 1-6 alkylsulfonyl group, or [5] a C 1-8 alkoxycarbonyl group,

(7) a C 6-10 aryl group which may be substituted by one or more R 9E ,

R 9E : [1] a halogen atom, [2] a hydroxy group, [3] a hydroxycarbonyl group, or [4] a C 1-8 alkyl group which may be substituted by hydroxy group(s), or [5] a C 1-8 alkoxy group,

(8) a 5- to 14-membered heteroaryl group which may be substituted by C 1-8 alkyl group(s),

(9) a cyano group,

(10) a C 1-8 alkanoyl group,

(11) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by C 1-8 alkyl group(s),

(12) a halogen atom,

(13) a (C 1-8 alkyl) m9c -amino group which may be substituted by one or more R 9F ,

R 9F : [9F-1] a C 1-3 alkylsulfonyl group, [9F-2] a (C 1-3 alkyl) m9f1 -aminosulfonyl group (m9f1: 0˜2), or [9F-3] a C 1-3 alkanoyl group which may be substituted by (C 1-3 alkyl) m9f2 -amino group(s) (m9f2: 0˜2),

m9c: 0˜2

(14) a C 1-8 alkylcarbonyl(C 0-8 alkyl)amino group which may be substituted by (C 1-8 alkyl) m9d -amino group(s),

m9d: 0˜2,

(15) a C 1-8 alkylsulfonyl(C 0-8 alkyl)amino group,

(16) a (C 1-8 alkyl) m9e -aminosulfonyl(C 0-8 alkyl)amino group,

m9e: 0˜2,

(17) a nitro group,

(18) a hydroxy group,

(19) a C 1-8 alkoxy group which may be substituted by one or more R 9G ,

R 9G : [1] a hydroxy group, [2] a hydroxycarbonyl group, [3] a C 6-10 aryl group which may be substituted by C 1-8 alkoxy group(s), [4] a (C 1-8 alkyl) m9g1 -amino group, [5] a C 1-8 alkoxy group which may be substituted by one or more R 9G1 , [6] a 5- to 14-membered heteroaryl group, or [7] a 4- to 10-membered heterocycloalkyloxy group which may be substituted by C 1-8 alkyl group(s),

m9g1: 0˜2,

R 9G1 : [1] a C 1-8 alkoxy group, or [2] a hydroxycarbonyl group,

(20) a 4- to 10-membered heterocycloalkyloxy group which may be substituted by [1] 4- to 10-membered heterocycloalkyl group(s), or [2] C 1-8 alkoxycarbonyl group(s),

(21) a C 1-8 alkylsulfonyloxy group which may be substituted by halogen atom(s),

(22) a C 1-8 alkylthio group which may be substituted by (C 1-8 alkyl) m9f -amino group(s),

m9f: 0˜2,

(23) a C 1-8 alkylsulfonyl group which may be substituted by (C 1-8 alkyl) m9g -amino group(s),

m9g: 0˜2,

(24) a (C 1-8 alkyl) m9h -aminosulfonyl group,

m9h: 0˜2,

(25) a 4- to 10-membered nitrogen-containing heterocycloalkylsulfonyl group which may be substituted by C 1-8 alkyl group(s), and

(26) a hydroxycarbonyl group.

2. The compound according to claim 1 , or a salt or solvate thereof, wherein R 3 is a cyano group or a halogen atom.

3. The compound according to claim 1 , or a salt or solvate thereof, wherein A 5 is NR 5 and R 5 is a hydrogen atom.

4. The compound according to claim 1 , or a salt or solvate thereof, wherein:

A 1 , A 2 , A 3 , A 4 , A 7 , A 8 , A 9 and A 10 all represent C;

A 5 is selected from NR 5 , O and S;

R 1 represents [1] a hydrogen atom, [2] a cyano group, or [3] a halogen atom;

R 2 is selected from the group consisting of:

(1) a hydrogen atom,

(2) a C 1-8 alkyl group,

(3) a cyano group,

(4) a halogen atom, and

(5) a (C 1-8 alkyl)-amino group which may be substituted by C 1-8 alkylsulfonyl group(s),

m2: 0˜2;

R 3 is selected from the group consisting of:

(1) a hydrogen atom,

(2) a C 1-8 alkyl group which may be substituted by halogen atom(s),

(3) a cyano group,

(4) a (C 1-8 alkyl) m3a -aminocarbonyl group which may be substituted by one or more R 3A ,

R 3A : [1] a C 6-10 aryl group, [2] a C 1-8 alkoxy group, [3] a 5- to 14-membered heteroaryl group, or [4] a C 6-10 aryl sulfonyl group,

m3a: 0˜2,

(5) a hydroxycarbonyl group,

(6) a C 1-8 alkoxycarbonyl group which may be substituted by hydroxy group(s),

(7) a halogen atom,

(8) a (C 1-8 alkyl) m3b -amino group which may be substituted by C 6-10 aryl group(s),

m3b: 0˜2,

(9) a C 1-8 alkylcarbonyl (C 0-8 alkyl)amino group which may be substituted by [1] C 6-10 aryl group(s) or [2] C 6-10 aryloxy group(s),

(10) a C 6-10 arylcarbonyl (C 0-8 alkyl)amino group which may be substituted by C 1-8 alkyl group(s) which may be substituted by halogen atom(s),

(11) a nitro group,

(12) a hydroxy group,

(13) a C 1-8 alkoxy group which may be substituted by one or more R 3B ,

R 3B : [1] a hydroxy group, [2] a C 1-8 alkoxy group, [3] a C 6-10 aryl (C 0-8 alkyl)aminocarbonyl group, [4] a (C 1-8 alkyl) m3d -amino group, or [5] a halogen atom,

m3 d: 0˜2,

(14) a 4- to 10-membered heterocycloalkyloxy group,

(15) a 5- to 14-membered heteroaryloxy group,

(16) a (C 1-8 alkyl) m3e -aminocarbonyloxy group which may be substituted by C 6-10 aryl group(s),

m3e: 0˜2,

(17) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group,

(18) a C 1-8 alkylthio group,

(19) a 5- to 14-membered heteroaryl group which may be substituted by C 1-8 alkyl group(s) which may be substituted by C 1-8 alkoxy group(s),

(20) a C 1-8 alkoxycarbonyl (C 0-8 alkyl)amino group which may be substituted by C 1-8 alkoxy group(s),

(21) a C 6-10 aryloxycarbonyl (C 0-8 alkyl)amino group which may be substituted by C 1-8 alkyl group(s) which may be substituted by halogen atom(s),

(22) a C 6-10 aryl (C 0-8 alkyl)aminocarbonyl (C 0-8 alkyl)amino group which may be substituted by C 1-8 alkoxy group(s),

(23) a C 3-8 cycloalkyl (C 0-8 alkyl)aminocarbonyloxy group, and

(24) a C 6-10 aryl (C 0-8 alkyl)aminocarbonyloxy group which may be substituted by substituent(s) selected from the group consisting of [1] a C 1-8 alkyl group and [2] a C 1-8 alkoxy group;

R 4 is selected from the group consisting of:

(1) a hydrogen atom,

(2) a C 1-8 alkyl group which may be substituted by halogen atom(s),

(3) a C 3-8 cycloalkyl group,

(4) a cyano group,

(5) an aminocarbonyl group,

(6) a hydroxycarbonyl group,

(7) a halogen atom,

(8) a (C 1-8 alkyl) m4b -amino group,

m4b: 0˜2,

(9) a hydroxy group, and

(10) a C 1-8 alkoxy group which may be substituted by hydroxy group(s);

R 5 is selected from the group consisting of:

(1) a hydrogen atom,

(2) a C 1-8 alkyl group which may be substituted by one or more R 5A ,

R 5A : [1] a hydroxycarbonyl group, [2] a C 1-8 alkoxycarbonyl group, [3] a hydroxy group, [4] a C 1-8 alkoxy group, [5] a (C 1-8 alkyl) m5 -amino group, or [6] a C 1-8 alkylthio group,

m5: 0˜2, and

(3) a C 1-8 alkylsulfonyl group;

R 6 and R 6′ are each independently:

(1) a C 1-8 alkyl group, or

R 6 and R 6′ are taken together with the carbon atoms to which they are bound to form,

(2) a C 3-8 cycloalkyl group, or

(3) a 4- to 10-membered heterocycloalkyl group;

R 7 is selected from the group consisting of:

(1) a hydrogen atom,

(2) a halogen atom, and

(3) a C 1-8 alkoxy group which may be substituted by one or more R 7A ,

R 7A : [1] a (C 1-8 alkyl) m7a -amino group, or [2] a hydroxy group,

m7a:0˜2;

R 8 is selected from the group consisting of:

(1) a hydrogen atom,

(2) a C 1-8 alkyl group which may be substituted by one or more R 8A ,

R 8A : [1] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R 8A1 , [2] a (C 1-8 alkyl) m8a -amino group which may be substituted by a halogen atom, or [3] a hydroxy group,

m8a:0˜2,

R 8A1 : [1] a C 1-8 alkyl group, [2] a C 1-8 alkylsulfonyl group, [3] a (C 1-8 alkyl) m8b -aminosulfonyl group, or [4] an oxo group,

m8b: 0˜2,

(3) a C 2-8 alkenyl group,

(4) a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R 8B ,

R 8B :

<1> a C 1-8 alkyl group which may be substituted by one or more R 8B1 ,

<2> a C 2-8 alkynyl group,

<3> a C 3-8 cycloalkyl group which may be substituted by [1] cyano group(s) or [2] C 1-8 alkyl group(s),

<4> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R 8B2 ,

<5> a C 1-8 alkoxy group which may be substituted by substituent(s) selected from the group consisting of [1] a C 1-8 alkoxy group and [2] a C 3-8 cycloalkyl group,

<6> a C 1-8 alkylsulfonyl group,

<7> an oxo group,

<8> a cyano group,

<9> a C 1-8 alkanoyl group which may be substituted by one or more R 8B3 ,

<10> a C 3-8 cycloalkylcarbonyl group,

<11> a (C 1-8 alkyl) m8c -aminosulfonyl group,

<12> a C 1-8 alkylsulfonyl (C 0-8 alkyl)amino group,

<13> a (C 1-8 alkyl) m8d -amino group which may be substituted by one or more R 8B4 ,

<14> a hydroxy group, or

<15> a (C 1-8 alkyl) m8e -aminocarbonyl group,

m8c: 0˜2,

m8d: 0˜2,

m8e: 0˜2,

R 8B1 : [1] a C 3-8 cycloalkyl group, [2] a hydroxy group, or [3] C 1-8 alkoxy group,

R 8B2 : [1] a halogen atom, [2] a C 1-8 alkyl group, [3] an oxo group, or [4] a hydroxy group

R 8B2 : [1] a halogen atom, [2] a C 1-8 alkyl group, [3] an oxo group, or [4] a hydroxy group,

R 8B3 : a (C 1-8 alkyl) m8f -amino group,

m8f: 0˜2,

R 8B4 : [1] a C 3-8 cycloalkyl group, or [2] a hydroxy group,

(5) a 5- to 14-membered heteroaryl group which may be substituted by a C 1-8 alkyl group,

(6) a (C 1-8 alkyl) m8g -aminocarbonyl group which may be substituted by one or more R 8C ,

m8g: 0˜2,

R 8C : [1] a hydroxy group, [2] a (C 1-8 alkyl) m8h -amino group which may be substituted by substituent(s) selected from the group consisting of <1> a (C 1-8 alkyl) m8i -aminosulfonyl group and <2> a C 1-8 alkylsulfonyl group, or [3] a C 1-8 alkylsulfonyl group,

m8h: 0˜2,

m8i: 0˜2,

(7) a 4- to 10-membered heterocycloalkyl (C 0-8 alkyl)aminocarbonyl group which may be substituted by oxo group(s),

(8) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by one or more R 8D ,

R 8D : [1] a C 1-8 alkyl group which may be substituted by one or more R 8D1 , [2] a hydroxy group, or [3] a C 1-8 alkylsulfonyl group,

R 8D1 : [1] a hydroxy group, or [2] a C 1-8 alkoxy group,

(9) a hydroxycarbonyl group,

(10) a C 0-8 alkoxy (C 0-8 alkyl)aminocarbonyl group which may be substituted by hydroxy group(s),

(11) a halogen atom,

(12) a (C 1-8 alkyl) m8j -amino group which may be substituted by 4- to 10-membered heterocycloalkyl group(s),

m8j: 0˜2,

(13) a hydroxyl group,

(14) a C 1-8 alkoxy group which may be substituted by one or more R 8E ,

R 8E :

<1> a hydroxy group,

<2> a C 1-8 alkoxycarbonyl group,

<3> a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by one or more R 8E1 ,

<4> a (C 1-8 alkyl) m8k1 -amino group which may be substituted by one or more R 8E2 ,

m8k1: 0˜2,

<5> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R 8E3 ,

<6> a 5- to 14-membered heteroaryl group,

<7> a (C 1-8 alkyl) m8k2 -aminocarbonyl group which may be substituted by one or more R 8E6

m8k2: 0˜2,

<8> a C 1-8 alkoxy group which may be substituted by one or more R 8E7 ,

<9> a C 1-8 alkylthio group,

<10> a C 1-8 alkylsulfinyl group, or

<11> a C 1-8 alkylsulfonyl group,

R 8E1 :

<1> a C 1-8 alkoxycarbonyl group,

<2> a C 1-8 alkanoyl group,

<3> a C 1-8 alkylsulfonyl group,

<4> a (C 1-8 alkyl) m8k3 -aminosulfonyl group

m8k3: 0˜2, or

<5> a 4- to 10-membered heterocycloalkyl group,

R 8E2 :

<1> a hydroxy group,

<2> a C 1-8 alkoxycarbonyl group,

<3> a C 3-8 cycloalkyl group which may be substituted by C 1-8 alkyl group(s) which may be substituted by hydroxy group(s),

<4> a C 1-8 alkanoyl group which may be substituted by substituent(s) selected from the group consisting of [1] a (C 1-8 alkyl) m8k4 -amino group and [2] a halogen atom,

m8k4: 0˜2,

<5> a (C 1-8 alkyl) m8k5 -aminocarbonyl group,

m8k5: 0˜2,

<6> a C 1-8 alkylsulfonyl group,

<7> a 4- to 10-membered nitrogen-containing heterocycloalkylsulfonyl group which may be substituted by C 1-8 alkyl group(s),

<8> a (C 1-8 alkyl) m8k6 -aminosulfonyl group,

m8k6: 0˜2, or

R 8E3 :

<1> a C 1-8 alkyl group which may be substituted by substituent(s) selected from the group consisting of [1] a hydroxy group and [2] a C 1-8 alkylcarbonyloxy group,

<2> a hydroxy group,

<3> a C 3-8 cycloalkyl group,

<4> a C 1-8 alkylsulfonyl group,

<5> a (C 1-8 alkyl) m8k8 -aminocarbonyl group,

m8k8: 0˜2,

<6> a C 1-8 alkanoyl group which may be substituted by hydroxy group(s),

<7> an oxo group, or

<8> a 4- to 10-membered heterocycloalkyl group which may be substituted by substituent(s) selected from the group consisting of [1] a C 1-8 alkanoyl group, and [2] a C 1-8 alkylsulfonyl group,

R 8E6 :

<1> a C 2-8 alkenylcarbonyloxy group,

<2> a hydroxy group,

<3> a cyano group,

<4> a (C 1-8 alkyl) m8k9 -amino group which may be substituted by hydroxy group(s),

m8k9: 0˜2,

<5> a C 1-8 alkoxy group which may be substituted by hydroxy group(s),

<6> a 4- to 10-membered heterocycloalkyl group which may be substituted by C 1-8 alkyl group(s), or

<7> a 5- to 14-membered heteroaryl group,

R 8E7 :

<1> a hydroxy group, or

<2> a C 1-8 alkoxy group which may be substituted by hydroxy group(s),

(15) a 4- to 10-membered heterocycloalkyloxy group which may be substituted by one or more R 8F :

R 8F :

<1> a C 1-8 alkyl group which may be substituted by one or more R 8F1 ,

<2> a C 3-8 cycloalkyl group,

<3> a C 1-8 alkanoyl group which may be substituted by halogen atom(s),

<4> a C 1-8 alkoxycarbonyl group,

<5> a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R 8F2 ,

<6> a C 1-8 alkyl sulfonyl group, or

<7> a hydroxy group,

R 8F1 : [1] a hydroxy group, [2] a C 1-8 alkoxy group, or [3] a halogen atom,

R 8F2 : [1] a 4- to 10-membered heterocycloalkyl group, [2] a C 1-8 alkoxycarbonyl group, or [3] a C 1-8 alkylsulfonyl group,

(16) a 5- to 14-membered heteroaryloxy group,

(17) a (C 1-8 alkyl) m8l1 -aminosulfonyloxy group,

m8l1: 0˜2,

(18) a C 1-8 alkylthio group which may be substituted by (C 1-8 alkyl) m8l2 -amino group(s),

m8l2: 0˜2,

(19) a C 1-8 alkylsulfonyl group which may be substituted by one or more R 8G ,

R 8G : [1] a hydroxycarbonyl group, [2] a hydroxy group, or [3] a (C 1-8 alkyl) m8l3 -amino group,

m8l3: 0˜2,

(20) a C 2-8 alkenyloxy group, and

(21) a C 1-8 alkylsulfonyloxy group which may be substituted by halogen atom(s);

R 9 is selected from the group consisting of:

(1) a hydrogen atom,

(2) a C 1-8 alkyl group which may be substituted by one or more R 9A ,

R 9A : [1] a C 3-8 cycloalkyl group, [2] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R 9A1 , [3] a hydroxy group, or [4] a C 1-8 alkoxy group,

R 9A1 : [1] a C 1-8 alkyl group, [2] a C 3-8 cycloalkyl group, or [3] a 4- to 10-membered heterocycloalkyl group,

(3) a C 2-8 alkenyl group,

(4) a C 2-8 alkynyl group which may be substituted by one or more R 9C ,

R 9C : [1] a C 1-8 alkoxy group, [2] a (C 1-8 alkyl) m9b -amino group which may be substituted by C 6-10 aryl group(s), [3] a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R 9C1 , [4] a C 3-8 cycloalkyl group, [5] a hydroxy group, or [6] a hydroxycarbonyl group,

m9b: 0˜2,

R 9C1 : [1] a C 3-8 cycloalkyl group, [2] a 4- to 10-membered heterocycloalkyl group, or [3] an oxo group,

(5) a C 3-8 cycloalkyl group,

(6) a 4- to 10-membered heterocycloalkyl group which may be substituted by one or more R 9D ,

R 9D : [1] a C 1-8 alkyl group which may be substituted by 4- to 10-membered heterocycloalkyl group(s), [2] a C 3-8 cycloalkyl group, [3] a 4- to 10-membered heterocycloalkyl group, or [4] a C 1-6 alkylsulfonyl group,

(7) a C 6-10 aryl group which may be substituted by one or more R 9E ,

R 9E : [1] a halogen atom, [2] a hydroxy group, [3] a hydroxycarbonyl group, or [4] a C 1-8 alkyl group which may be substituted by hydroxy group(s),

(8) a 5- to 14-membered heteroaryl group which may be substituted by C 1-8 alkyl group(s),

(9) a cyano group,

(10) a C 1-8 alkanoyl group,

(11) a 4- to 10-membered nitrogen-containing heterocycloalkylcarbonyl group which may be substituted by C 1-8 alkyl group(s),

(12) a halogen atom,

(13) a (C 1-8 alkyl) m9e -amino group,

m9c: 0˜2,

(14) a C 1-8 alkylcarbonyl(C 0-8 alkyl)amino group which may be substituted by (C 1-8 alkyl) m9d -amino group(s),

m9d: 0˜2,

(15) a C 1-8 alkylsulfonyl(C 0-8 alkyl)amino group,

(16) a (C 1-8 alkyl) m9e -aminosulfonyl(C 0-8 alkyl)amino group,

m9e: 0˜2,

(17) a nitro group,

(18) a hydroxy group,

(19) a C 1-8 alkoxy group which may be substituted by one or more R 9G ,

R 9G : [1] a hydroxy group, [2] a hydroxycarbonyl group, [3] a C 6-10 aryl group which may be substituted by C 1-8 alkoxy group(s), [4] a (C 1-8 alkyl) m9g1 -amino group, [5] a C 1-8 alkoxy group which may be substituted by one or more R 9G1 , or [6] a 5- to 14-membered heteroaryl group,

m9g1: 0˜2,

R 9G1 : [1] a C 1-8 alkoxy group, or [2] a hydroxycarbonyl group,

(20) a 4- to 10-membered heterocycloalkyloxy group which may be substituted by 4- to 10-membered heterocycloalkyl group(s),

(21) a C 1-8 alkylthio group which may be substituted by (C 1-8 alkyl) m9f -amino group(s),

m9f: 0˜2,

(22) a C 1-8 alkylsulfonyl group which may be substituted by (C 1-8 alkyl) m9g -amino group(s),

m9g: 0˜2,

(23) a (C 1-8 alkyl) m9h -aminosulfonyl group,

m9h: 0˜2, and

(24) a 4- to 10-membered nitrogen-containing heterocycloalkylsulfonyl group which may be substituted by C 1-8 alkyl group(s);

R 10 represents [1] a hydrogen atom, or [2] a 4- to 10-membered heterocycloalkyl group which may be substituted by 4- to 10-membered heterocycloalkyl group(s)].

5. A compound or salt or solvate as claimed in claim 1 of 9-(4-isopropyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

6. A compound or salt or solvate as claimed in claim 1 of 6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-9-prop-1-ynyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

7. A compound or salt or solvate as claimed in claim 1 of 9-cyclopropylethynyl-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

8. A compound or salt or solvate as claimed in claim 1 of 6,6-dimethyl-8-(1-oxetan-3-yl-piperidin-4-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

9. A compound or salt or solvate as claimed in claim 1 of 9-bromo-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

10. A compound or salt or solvate as claimed in claim 1 of 9-bromo-8-(4-cyclopropyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

11. A compound or salt or solvate as claimed in claim 1 of 9-chloro-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

12. A compound or salt or solvate as claimed in claim 1 of 8-(4-cyclobutyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-9-prop-1-ynyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

13. A compound or salt or solvate as claimed in claim 1 of 6,6,9-trimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

14. A compound or salt or solvate as claimed in claim 1 of 9-ethyl-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

15. A compound or salt or solvate as claimed in claim 1 of 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

16. A compound or salt or solvate as claimed in claim 1 of 9-ethynyl-6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

17. A compound or salt or solvate as claimed in claim 1 of 8-(4-cyclobutyl-piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

18. A compound or salt or solvate as claimed in claim 1 of 9-ethynyl-6,6-dimethyl-11-oxo-8-(4-pyrrolidin-1-yl-piperidin-1-yl)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

19. A compound or salt or solvate as claimed in claim 1 of 6,6-dimethyl-11-oxo-8-(4-pyrrolidin-1-yl-piperidin-1-yl)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

20. A compound or salt or solvate as claimed in claim 1 of 8-(4-cyclobutyl-piperazin-1-yl)-9-ethynyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

21. A compound or salt or solvate as claimed in claim 1 of 8-(4-cyclobutyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-9-propyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

22. A compound or salt or solvate as claimed in claim 1 of 8-(1-isopropyl-piperidin-4-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

23. A compound or salt or solvate as claimed in claim 1 of 8-(4-isopropyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

24. A compound or salt or solvate as claimed in claim 1 of 8-(4-cyclobutyl-piperazin-1-yl)-9-cyclopropyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

25. A compound or salt or solvate as claimed in claim 1 of 8-(2-tert-butylamino-ethoxy)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

26. A compound or salt or solvate as claimed in claim 1 of 9-ethynyl-8-(4-methanesulfonyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

27. A compound or salt or solvate as claimed in claim 1 of 9-bromo-8-(4-cyclobutyl-piperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

28. A compound or salt or solvate as claimed in claim 1 of 6,6-dimethyl-8-(4-oxetan-3-yl-piperazin-1-yl)-11-oxo-9-propyl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.

29. A compound or salt or solvate as claimed in claim 1 of 9-ethynyl-6,6-dimethyl-8-morpholin-4-yl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile.