Anti-EGFR antibodies and uses thereof
The present invention provides antibodies that bind to EGFR and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human EGFR with high affinity. In certain embodiments, the antibodies of the present invention are capable of inhibiting the growth of tumor cells expressing high levels of EGFR and/or inducing antibody-dependent cell-mediated cytotoxicity (ADCC) of such cells. The antibodies of the invention are useful for the treatment of various cancers as well as other EGFR-related disorders.
1. An isolated antibody, or antigen-binding fragment thereof, that specifically binds human epidermal growth factor receptor (hEGFR), wherein the antibody or antigen-binding fragment comprises: (a) the complementarity determining regions (CDRs) of a heavy chain variable region (HCVR) having an amino acid sequence of SEQ ID NO: 130 and (b) the CDRs of a light chain variable region (LCVR) having an amino acid sequence of SEQ ID NO: 138.
2. The isolated antibody or antigen-binding fragment of claim 1 , wherein the antibody or antigen-binding fragment comprises the heavy and light chain CDRs of a HCVR/LCVR amino acid sequence pair having SEQ ID NOs: 130/138.
3. The isolated antibody or antigen-binding fragment of claim 2 , wherein the antibody or antigen-binding fragment comprises HCDR1-HCDR2-HCDR3-LCDR1-LCDR2-LCDR3 domains, respectively, having SEQ ID NOs: 132-134-136-140-142-144.
4. A pharmaceutical composition comprising the antibody or antigen-binding fragment of claim 1 , and a pharmaceutically acceptable carrier or diluent.