Glucosylceramide synthase inhibitors

Inventors: Elyse Bourque (Blaine, WA); Bradford Hirth (Framingham, MA); Renato Sklerj (West Newton, MA); Elina Makino (Winchester, MA); Fazeela Morshed (Waltham, MA); Lingyun Li (Waltham, MA); Paul Mason (Natick, MA); John P. Leonard (Manchester, NH); James Lillie (Wellesley, MA); Hanlan Liu (Lexington, MA); Mary A. Cromwell (Groton, MA); Bing Wang (Newton, MA); Thomas O'Shea (Wellesley, MA)

Assignee: Genzyme Corporation

C07D453/02 A61K31/439 A61K31/454 A61K38/47 C07D453/00

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Quick Facts

Patent No.: US 9,139,580
App. No.: 14/030,725
Granted: Sep 22, 2015
Kind: B2

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Abstract

The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Claims (2)

1. A compound represented by the following structural formula,

or a pharmaceutically acceptable salt thereof.

Assignments (5)