Skeletal muscle regeneration promoter
Provided is a skeletal muscle regeneration promoter for a muscular disorder or myopathy comprising a chondroitinase as an active component, which skeletal muscle regeneration promoter enhances, when administered into a muscular fiber of a mammal with the muscular disorder or myopathy, the regeneration of such a muscular fiber. The above-mentioned chondroitinase degrades chondroitin sulfate that is present at the outer perimeter of the above-mentioned muscular fiber; and thereby inhibition of the regeneration of the muscular fiber by the above-mentioned chondroitin sulfate disappears, which makes it possible to enhance the regeneration and enlargement of such a muscular fiber.
1. A method for promoting skeletal muscle regeneration for muscular dystrophy comprising:
administering to a muscular fiber of a subject in need thereof an effective amount of chondroitinase ABC, wherein said chondroitinase ABC, when administered into a muscular fiber of a mammal with muscular dystrophy, enhances regeneration of the muscular fiber.
2. The method according to claim 1 , wherein said administering comprises injecting chondroitinase ABC into the muscular fiber.
3. The method according to claim 1 , wherein said administration is combined with a treatment comprising any of a stem cell therapy and a therapy using an inhibitor of myostatin derived from a cytokine having a function of suppressing muscle mass.