Conjugate comprising P21 protein for the treatment of cancer
The P21 protein is used as a medicament in the treatment of cancer. A conjugate comprises a first region comprising the P21 protein, or a homologue or functional fragment thereof; and a second region comprising a translocation factor.
1. A method for the treatment of cancer, comprising administering to a subject in need thereof, a conjugate comprising:
a) a first region consisting of a protein having the amino acid sequence as set forth in SEQ ID NO:1;
b) a second region comprising the homeodomain of antennapedia; and
c) a covalent linker.
2. The method according to claim 1 , wherein the conjugate is a fusion protein.
3. The method according to claim 1 , further comprising administering another agent to the subject, wherein the agent is therapeutic in the treatment of cancer.
4. The method according to claim 3 , wherein the agent is a chemotherapeutic drug.
5. The method of claim 1 , wherein the cancer is colorectal cancer, ovarian cancer, pancreatic cancer, cervical cancer, or osteocarcinoma.
6. The method of claim 4 , wherein the agent is cisplatin or taxol.