IP Library › Granted Patent US 9,187,426
Granted Patent B2
US 9,187,426 · App. 13/000,413 · Granted Nov 17, 2015

Organic compounds

Inventors: Natalie Dales (Cambridge, MA); Zaihui Zhang (Burnaby, CA); Jianmin Fu (Burnaby, CA); Duanjie Hou (Burnaby, CA); Shaoyi Sun (Burnaby, CA); Vishnumurthy Kodumuru (Burnaby, CA); Natalia Pokrovskaia (Burnaby, CA)
Assignees: Novartis AG; Xenon Pharmaceuticals
C07D213/81A61K31/444A61K31/4439C07D401/04C07D401/14C07D409/12C07D413/04C07D413/14C07D417/14
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Quick Facts
Patent No.
US 9,187,426
App. No.
13/000,413
Granted
Nov 17, 2015
Kind
B2
Abstract

The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

Claims (7)

1. A compound selected from:

2-(3-(cyclopropylmethyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-2-ylmethyl)isonicotinamide,

2-(3-(3,4-difluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-2-ylmethyl)-isonicotinamide,

2-(2-oxo-3-(4-(trifluoromethyl)benzyl)imidazolidin-1-yl)-N-(pyridin-2-ylmethyl)-isonicotinamide, and

2-(2-oxo-3-(4-(trifluoromethoxy)benzyl)imidazolidin-1-yl)-N-(pyridin-2-ylmethyl)-isonicotinamide, or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition, comprising:

the compound of Formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient or carrier.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 28, 2016
From: NOVARTIS AG
To: XENON PHARMACEUTICALS INC.
Reel/Frame 039876/0645 →
CORRECTIVE ASSIGNMENT TO CORRECT THE PLEASE REMOVE THE INCORRECT ASSIGNMENT RECORDED ON PREVIOUSLY RECORDED ON REEL 025794 FRAME 0838. ASSIGNOR(S) HEREBY CONFIRMS THE AND RECORD THE CORRECT ASSIGNMENT WITH THE CORRECT INVENTORS AND CLIENT IDENTIFIER.. Recorded Jul 21, 2011
From: DALES, NATALIE; ZHANG, ZAIHUI; FU, JIANMIN; HOU, DUANJIE; SUN, SHAOYI; KODUMURU, VISHNUMURTHY; POKOROVSKAIA, NATALIA
To: NOVARTIS AG; XENON PHARMACEUTICALS
Reel/Frame 026623/0609 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 8, 2011
From: DALES, NATALIE; ZHANG, ZAIHUI; FU, JIANMIN; HOU, DUANJIE; SUN, SHAOYI; KODUMURU, VISHNUMURTHY; POKOROVSKAIA, NATALIA
To: NOVARTIS AG
Reel/Frame 026562/0432 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 8, 2011
From: DALES, NATALIE; ZHANG, ZAIHUI; FU, JIANMIN; HOU, DUANJIE; SUN, SHAOYI; KODUMURU, VISHNUMURTHY; POKOROVSKAIA, NATALIA
To: XENON PHARMACEUTICALS INC.
Reel/Frame 026562/0611 →
Continuity (2)
Provisional Application 61076443 · Jun 27, 2008
Related Publication 20110105530A1 · May 5, 2011