Chalcones as enhancer of antimicrobial agents
Compounds are described that are effective in enhancing the efficacy of antimicrobial agents. Also described are methods of using such compounds and compositions that include such compounds. The composition includes a chalcone compound and, optionally, an antimicrobial agent.
1. A composition comprising a carrier and as active ingredients
an antimicrobial agent selected from zinc citrate, triclosan, tetrahydrocannabinol, cetyl pyridinium chloride, magnolia, magnolol, honokiol and butyl magnolol, and
one chalcone compound selected from the group consisting of 3-(4′-Hydroxy-3′-methoxy-phenyl)-1-(2′hydroxy-5′ methoxy-phenyl)-prop-2-ene-1-one, 3-(4′-Hydroxy-3′-methoxy-phenyl)-1phenyl-prop-2-ene-1-one, 3-(2″,3″-Dimethoxy-phenyl)-1-furan-2-yl-prop-2-ene-1-one, 3-(2″,5″-dimethoxy-phenyl)-1-(1H-pyrrol-2-yl)-prop-2-ene-1-one, and mixtures thereof.
2. The composition according to claim 1 , is an oral care composition, optionally wherein the oral care composition is in the form of a dentifrice selected from the group consisting of toothpaste, tooth powder, gel, rinse, lozenge, chewing gum, film, and mixtures thereof.
3. The composition of claim 1 , wherein the chalcone compound is 3-(4′-Hydroxy-3′-2-methoxy-phenyl)-1-phenyl-prop-2-ene-1-one.
4. A composition as claimed in claim 1 wherein the active ingredients are present in an effective concentration for treating a microbial infection by topical administration to the oral cavity of a mammal in need thereof.
5. A composition according to claim 4 wherein the microbial infection is caused by a bacterium.
6. A composition as claimed in claim 5 , wherein the composition is in the form of a dentifrice selected from the group consisting of toothpaste, tooth powder, gel, rinse, lozenge, chewing gum, film, and mixtures thereof.
7. A composition as claimed in claim 4 , wherein the chalcone compound is 3-(4′-Hydroxy-3′-methoxyphenyl)-1-phenyl-prop-2-ene-1-one.
8. A composition as claimed in claim 4 wherein the microbial count is reduced.
9. The composition of claim 1 wherein the antimicrobial agent is zinc citrate.
10. The composition of claim 9 wherein the chalcone compound is 3-(4′-hydroxy-3′-methoxyphenyl)-1-phenyl-prop-2-ene-1-one.