Nucleoside phosphoramidates
Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.
1. A compound represented by the formula (S P -4):
wherein the compound is monoclinic crystalline (S P -4) having unit cell parameters:
i) a˜12.88 Å, b˜6.17 Å, c˜17.73 Å, and β˜92.05°;
ii) a˜20.09 Å, b˜6.10 Å, c˜23.01 Å, and β˜112.29°;
iii) a˜12.83 Å, b˜6.15 Å, c˜17.63 Å, and β−91.75°; or
iv) a˜12.93 Å, b˜6.18 Å, c˜18.01 Å, and β˜96.40°.
2. A compound represented by the formula (S P -4):
wherein the compound is monoclinic crystalline having XRPD 2θ-reflections (°) at about:
i) 5.2, 7.5, 9.6, 16.7, 18.3, and 22.2;
ii) 5.0, 7.3, 9.4, and 18.1;
iii) 4.9, 6.9, 9.8, 19.8, 20.6, 24.7, and 26.1;
iv) 6.9, 9.8, 19.7, 20.6, and 24.6;
v) 5.0, 6.8, 19.9, 20.6, 20.9, and 24.9; or
vi) 5.2, 6.6, 7.1, 15.7, 19.1, and 25.0.
3. The compound of claim 2 having XRPD 2θ-reflections (°) at about:
i) 5.2, 7.5, 9.6, 16.7, 18.3, and 22.2; or
ii) 5.0, 7.3, 9.4, and 18.1.
4. A composition comprising the compound according to any one of claim 1 , 2 or 3 and a pharmaceutically acceptable medium.