Amphiphilic dendron-coils, micelles thereof and uses
The invention generally relates to the fields of drug delivery and cell capture. In particular, the invention relates to amphiphilic dendron-coils, micelles thereof and their use for drug delivery vehicles and/or cell capture.
1. A micelle comprising amphiphilic dendron-coils, wherein each amphiphilic dendron-coil comprises a non-peptidyl, hydrophobic core-forming block, a polyester dendron and a poly(ethylene) glycol (PEG) moiety, and wherein the non-peptidyl, hydrophobic core-forming block comprises a linear hydrophobic polymer.
2. The micelle of claim 1 wherein the linear hydrophobic polymer is polycaprolactone (PCL), poly(lactic acid) (PLA), poly(glycolic acid) (PGA) or poly(lactic-co-glycolic acid) (PLGA); wherein the polyester dendron is a generation 3 to generation 5 polyester dendron with either an acetylene or carboxylate core; and wherein the PEG moiety is a methoxy PEG (mPEG) moiety, amine-terminated PEG (PEG-NH 2 ) moiety, acetylated PEG (PEG-Ac) moiety, carboxylated PEG (PEG-COOH) moiety, thiol-terminated PEG (PEG-SH) moiety, N-hydroxysuccinimide-actived PEG (PEG-NHS) moiety, NH 2 -PEG-NH 2 moiety or NH 2 -PEG-COOH moiety.
3. The micelle of claim 1 or 2 wherein the linear hydrophobic polymer has a molecular weight from about 0.5 kDa to about 20 kDa.
4. The micelle of claim 1 wherein the polyester dendron is a generation 3 (G3) dendron.
5. The micelle of claim 1 wherein the polyester dendron is a generation 4 (G4) dendron.
6. The micelle of claim 1 wherein the polyester dendron is a generation 5 (G5) dendron.
7. The micelle of claim 4 wherein the polyester dendron is a generation 3 polyester-8-hydroxyl-1-acetylene bis-MPA dendron.
8. The micelle of claim 1 wherein the PEG moiety is a methoxy PEG (mPEG) moiety, amine-terminated PEG (PEG-NH 2 ) moiety, acetylated PEG (PEG-Ac) moiety, carboxylated PEG (PEG-COOH) moiety, thiol-terminated PEG (PEG-SH) moiety, N-hydroxysuccinimide-actived PEG (PEG-NHS) moiety, NH 2 -PEG-NH 2 moiety or NH 2 -PEG-COOH moiety.
9. The micelle of claim 8 wherein the PEG moiety has a molecular weight from about 0.2 kDa to about 5 kDa.
10. The micelle of claim 1 further comprising one or more ligands conjugated to one or more PEG moieties.
11. The micelle of claim 1 further comprising a drug.
12. The micelle of claim 11 wherein the drug is a cancer drug.
13. A composition comprising a micelle comprising amphiphilic dendron-coils, wherein each amphiphilic dendron-coil comprises a non-peptidyl, hydrophobic core-forming block, a polyester dendron and a poly(ethylene) glycol (PEG) moiety and wherein the non-peptidyl, hydrophobic core-forming block comprises a linear hydrophobic polymer.
14. A method of delivering a drug to a patient comprising administering a composition comprising a micelle and a pharmaceutically acceptable carrier,
wherein the micelle comprises amphiphilic dendron-coils and encapsulates the drug, and wherein each amphiphilic dendron-coil comprises a non-peptidyl, hydrophobic core-forming block, a polyester dendron and a poly(ethylene) glycol (PEG) moiety and wherein the non-peptidyl, hydrophobic core-forming block comprises a linear hydrophobic polymer.
15. An amphiphilic dendron-coil comprising a non-peptidyl, hydrophobic core-forming block, a polyester dendron and a poly(ethylene) glycol (PEG) moiety, wherein the non-peptidyl, hydrophobic core-forming block comprises a linear hydrophobic polymer.
16. The amphiphilic dendron-coil of claim 15 further comprising a ligand conjugated to the PEG moiety.