Chroman derivative
The invention provides a chroman derivative represented by the following Formula (I) that enables the production of an SMTP compound having a desired structure: wherein, in Formula (I), each of Y 1 and Y 2 independently represents a hydrogen atom, a hydroxy group, an alkoxy group, an aryloxy group, or a halogen atom; each of R 1 and R 2 independently represents a hydrogen atom, an alkyl group, an aryl group, an acyl group, an alkoxycarbonyl group, an aryloxycarbonyl group, or a carbamoyl group; L represents an aliphatic hydrocarbon group having from 4 to 10 carbon atoms; each X independently represents a hydroxy group or a carboxy group; and n represents an integer from 0 to 2.
1. A chroman derivative that is a compound represented by the following Formula (Ia):
wherein, in Formula (Ia), each of Y 1 and Y 2 independently represents a hydrogen atom, a hydroxy group, an alkoxy group, an aryloxy group, or a halogen atom; each of R 1 and R 2 independently represents a hydrogen atom, an alkyl group, an aryl group, an acyl group, an alkoxycarbonyl group, an aryloxycarbonyl group, or a carbamoyl group.
2. The chroman derivative according to claim 1 , wherein each of Y 1 and Y 2 represents a hydrogen atom.
3. A method of producing a compound represented by the following Formula (II), the method comprising a step of allowing a compound represented by the following Formula (Ia) to react with an amine compound represented by the following Formula (III) in the presence of a solvent:
wherein, in the formulae, each of Y1 and Y2 independently represents a hydrogen atom; each of R1 and R2 independently represents a hydrogen atom, an alkyl group, an aryl group, an acyl group, an alkoxycarbonyl group, an aryloxycarbonyl group, or a carbamoyl group; Xn-L- represents a group represented by the following Formula (L0):
wherein, in the Formula (L0), X 1 and X 2 are linked to each other to form a single bond, and * indicates a linking position;
Z 1 represents a methylene group, and Z 2 represents a carbonyl group; and R 3 represents a hydrogen atom, an alkyl group, an aryl group, or a heterocyclic group.
4. The chroman derivative according to claim 1 , wherein at least one of Y 1 or Y 2 represents a hydroxy group, an alkoxy group, an aryloxy group, or a halogen atom.
5. The chroman derivative according to claim 1 , wherein at least one of Y 1 or Y 2 represents a hydroxy group, an alkoxy group having from 1 to 12 carbon atoms, an aryloxy group having from 6 to 14 carbon atoms, or a halogen atom.
6. The chroman derivative according to claim 1 , wherein at least one of Y 1 or Y 2 represents a hydroxy group, an alkoxy group selected from the group consisting of methoxy group, an ethoxy group, a propoxy group, an isopropoxy group, a butoxy group, a t-butoxy group, a pentyloxy group, a hexyloxy group, a cyclohexyloxy group, an octyloxy group, an ethylhexyloxy group, a decyloxy group, and a dodecyloxy group, a phenyloxy group, or a halogen atom.
7. The chroman derivative according to claim 1 , wherein each of R 1 and R 2 independently represents a hydrogen atom, an alkyl group having from 1 to 12 carbon atoms, an aryl group having from 6 to 14 carbon atoms, an alkylcarbonyl group having an alkyl group having from 1 to 12 carbon atoms, an arylcarbonyl group having an aryl group having from 6 to 14 carbon atoms, an alkoxycarbonyl group selected from the group consisting of a methoxycarbonyl group, an ethoxycarbonyl group, a propyloxycarbonyl group, and a t-butyloxycarbonyl group, a phenoxycarbonyl group, or a carbamoyl group.
8. The chroman derivative according to claim 1 , wherein each of R 1 and R 2 independently represents a hydrogen atom, an alkyl group selected from the group consisting of a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, a t-butyl group, a pentyl group, a hexyl group, a cyclohexyl group, an octyl group, an ethylhexyl group, a decyl group, and a dodecyl group, an aryl group selected from the group consisting of a phenyl group, a naphthyl group, and an anthracenyl group, an alkylcarbonyl group having an alkyl group having from 1 to 4 carbon atoms, a phenylcarbonyl group, an alkoxycarbonyl group selected from the group consisting of a methoxycarbonyl group, an ethoxycarbonyl group, a propyloxycarbonyl group, and a t-butyloxycarbonyl group, a phenoxycarbonyl group, or a carbamoyl group.
9. The method according to claim 3 , wherein each of R 1 and R 2 independently represents a hydrogen atom, an alkyl group having from 1 to 12 carbon atoms, an aryl group having from 6 to 14 carbon atoms, an alkylcarbonyl group having an alkyl group having from 1 to 12 carbon atoms, an arylcarbonyl group having an aryl group having from 6 to 14 carbon atoms, an alkoxycarbonyl group selected from the group consisting of a methoxycarbonyl group, an ethoxycarbonyl group, a propyloxycarbonyl group, and a t-butyloxycarbonyl group, a phenoxycarbonyl group, or a carbamoyl group.
10. The method according to claim 3 , wherein each of R 1 and R 2 independently represents a hydrogen atom, an alkyl group selected from the group consisting of a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, a t-butyl group, a pentyl group, a hexyl group, a cyclohexyl group, an octyl group, an ethylhexyl group, a decyl group, and a dodecyl group, an aryl group selected from the group consisting of a phenyl group, a naphthyl group, and an anthracenyl group, an alkylcarbonyl group having an alkyl group having from 1 to 4 carbon atoms, a phenylcarbonyl group, an alkoxycarbonyl group selected from the group consisting of a methoxycarbonyl group, an ethoxycarbonyl group, a propyloxycarbonyl group, and a t-butyloxycarbonyl group, a phenoxycarbonyl group, or a carbamoyl group.