Closed loop optimization of control parameters during cardiac pacing

1. A method for optimizing a pacing control parameter, comprising:

determining a value of an EGM-based index corresponding to an optimal electrical activation condition of a patient's heart;

delivering a pacing therapy to the heart;

monitoring the EGM-based index during delivery of the pacing therapy to the heart; and

adjusting the pacing therapy to maintain the EGM-based index at the value corresponding to the optimal electrical activation condition in response to detection of a value of the EGM-based index corresponding to a non-optimal electrical activation condition during the monitoring of the EGM-based index.

2. The method of claim 1 , further comprising:

establishing a relationship between the EGM-based index and a plurality of settings of a pacing control parameter, wherein establishing the relationship comprises:

delivering cardiac pacing according to each of the plurality of settings comprising a previously established optimal setting and at least one non-optimal setting different than the optimal setting by a setting shift;

determining a value of the EGM-based index from an EGM signal acquired during cardiac pacing at each of the plurality of settings; and

storing the values of the determined index with corresponding setting shifts of each of the plurality of settings relative to the optimal setting; and

enabling a processor of an implantable medical device to:

monitor the EGM-based index during cardiac pacing,

responsive to detecting an EGM-based index value corresponding to a non-optimal setting of the control parameter, determine an adjustment of the control parameter from the stored index values and corresponding setting shifts, and

adjust the control parameter by the determined adjustment.

3. The method of claim 2 , further comprising establishing the optimal setting by sensing surface potentials from a plurality of surface electrodes positioned on a patient's body and computing an index of ventricular dyssynchrony for each of a plurality of pacing control parameter settings in response to the sensed surface potentials.

4. The method of claim 2 , wherein acquiring the EGM signal comprises selecting a sensing vector comprising a left ventricular electrode and a right ventricular coil electrode.

5. The method of claim 2 , further comprising determining a magnitude and polarity of a setting shift corresponding to the detected EGM-based index corresponding to a non-optimal setting; and

determining the adjustment as the magnitude and a polarity opposite to the setting shift corresponding to the detected EGM-based index.

6. The method of claim 2 , wherein establishing the optimal pacing control parameter comprises establishing an optimal atrio-ventricular (AV) delay during cardiac resynchronization therapy.

7. The method of claim 2 , further comprising establishing an optimal pacing control parameter and relationship between the EGM-based index and a plurality of settings of the control parameter for each of a plurality of different heart rhythm states.

8. The method of claim 2 , further comprising establishing an optimal pacing control parameter and a relationship between the EGM-based index and a plurality of settings of the control parameter for each of a plurality of pacing electrode vectors.

9. The method of claim 2 , further comprising storing the relationship as a look-up table of determined EGM-based index values and associated setting shifts in a memory of an implantable medical device accessed by the processor.

10. The method of claim 2 , further comprising:

detecting an unchanged value of the EGM-based index in response to an adjustment of the control parameter;

and switching a pacing mode in response to the unchanged value.

11. The method of claim 1 , wherein determining the EGM-based index comprises detecting a maximum peak amplitude of the EGM signal following a pacing pulse.

12. The method of claim 1 , wherein determining the EGM-based index comprises determining a time interval between a maximum peak amplitude and a minimum peak amplitude of the EGM signal following a pacing pulse.

13. A non-transitory, computer-readable storage medium comprising instructions that, when executed, cause a processor included in a medical device system to:

determine a value of an EGM-based index corresponding an optimal electrical activation condition of a patient's heart;

control a signal generator to deliver a pacing therapy to the heart;

monitor the EGM-based index during delivery of the pacing therapy to the heart; and

adjust a pacing therapy control parameter to maintain the EGM-based index value corresponding to the optimal electrical activation condition in response to detection of a value of the EGM-based index corresponding to a non-optimal electrical activation condition during the monitoring of the EGM-based index.

14. The computer-readable storage medium of claim 13 further comprising instructions that, when executed, cause the processor to:

establish a relationship between an EGM-based index and a plurality of settings of a pacing control parameter, wherein establishing the relationship comprises:

delivering cardiac pacing pulses according to each of the plurality of settings comprising a previously established optimal setting and at least one non-optimal setting different than the optimal setting by a setting shift;

determining a value of the EGM-based index from the EGM signal acquired during cardiac pacing at each of the plurality of settings; and

storing the values of the determined index with corresponding setting shifts of each of the plurality of settings relative to the optimal setting;

monitor the EGM-based index during cardiac pacing;

responsive to detecting an EGM-based index value corresponding to a non-optimal setting of the control parameter, determine an adjustment of the control parameter from the stored index values and corresponding setting shifts; and

adjust the control parameter by the determined adjustment.