Device and filter cartridge for separating plasma from whole blood

1. A multi-part device for separating plasma from whole blood, comprising:

a sample taking unit for receiving whole blood,

a filter unit with a layered filter with multiple layers for extracting plasma, and

a pumping unit having a plunger for creating a partial vacuum in the filter unit, wherein

the filter unit and a plasma collector vessel having a conical tip extending towards the filter unit are contained in a filter cartridge,

the conical tip of the plasma collector vessel penetrates a seal towards the filter unit and the collector vessel is held on its opposite end by a supporting element, which has a hydrophobic, air-permeable passage that leads to the pumping device and that prevents the outflow of separated plasma from the plasma collector vessel,

the filter cartridge is separable after plasma extraction, thus exposing the conical tip of the plasma collector vessel for sample input into an analyser, and

the volume between the seal towards the filter unit and the supporting element defines a compensation volume of the filter cartridge that is separate from the plasma interior volume of the collector vessel and wherein the compensation volume of the filter cartridge is connected to the pumping device via an air-permeable connection,

wherein both the interior volume of the plasma collector vessel and the compensation volume are in air communication via the hydrophobic, air-permeable passage and the air-permeable connection when the plunger is displaced from the supporting element forming a suction volume to create the partial vacuum in the filter unit.

2. The device according to claim 1 , wherein the supporting element is a clamping seal.

3. The device according to claim 1 , wherein the air-permeable connection is a compensation opening or a porous membrane.

4. The device according to claim 1 , wherein the filter cartridge is separable by pulling, screwing or wrenching off a plasma applicator containing the plasma collector vessel with its conical tip from the filter housing that contains the filter unit.

5. The device according to claim 1 , wherein the multi-layer layered filter of the filter unit comprises a deep-bed filter, a stop membrane and a lateral grid.

6. The device according to claim 1 , wherein the filter cartridge is disposed or integrated in a plunger syringe or is insertable into said syringe.

7. The device according to claim 6 , wherein the plunger of the syringe in its initial position prior to plasma extraction rests against the supporting element of the filter cartridge and at the end of plasma extraction locks into a locking position.

8. A filter cartridge with a multi-layer filter unit for extracting plasma from whole blood, wherein the filter cartridge in its interior has a conical plasma collector vessel, whose tip penetrates a seal towards the filter unit, the plasma collector vessel being held at its other end in the filter cartridge by a supporting element which has a hydrophobic air-permeable passage leading to a connectable pumping device, and wherein the volume between the seal and the supporting element defines a compensation volume of the filter cartridge that is separate from the interior volume of the plasma collector vessel and wherein the compensation volume of the filter cartridge is also connectable to the pumping device via an air-permeable connection.

9. The filter cartridge according to claim 8 , wherein the supporting element is a clamping seal.

10. The filter cartridge according to claim 8 , wherein the filter cartridge is separable by pulling off, wrenching off or screwing off a plasma applicator containing the conical plasma collector vessel from a filter housing containing the filter unit, thus exposing the tip of the plasma collector vessel for sample input into an analyser.