Vaccine carrier
The present invention relates to a hypoallergenic protein consisting of at least one hypoallergenic molecule derived from an allergen, which is fused or conjugated to at least one second non-allergenic protein or fragment thereof.
1. A recombinant hypoallergenic protein comprising a peptide fused or conjugated to a viral protein or a viral protein fragment, wherein the peptide is selected from the group consisting of amino acids 1 to 33 of SEQ ID NO:10; amino acids 2 to 31 of SEQ ID NO:12, and amino acids 2 to 38 of SEQ ID NO:14.
2. The recombinant hypoallergenic protein according to claim 1 , wherein the peptide is fused to the N-terminus, the C-terminus or both of the viral protein or the viral protein fragment.
3. The hypoallergenic protein according to claim 1 , wherein the viral protein is a capsid protein.
4. The hypoallergenic protein according to claim 1 , wherein the viral protein is a human pathogenic virus protein.
5. The hypoallergenic protein according to claim 4 , wherein the human pathogenic virus is a human rhinovirus 89 or human rhinovirus 14.
6. A nucleic acid molecule encoding the recombinant hypoallergenic protein according to claim 1 .
7. A vector comprising the nucleic acid molecule according to claim 6 .
8. The vector according to claim 7 , wherein said vector is an expression vector.
9. The vector according to claim 7 , wherein said vector is a bacterial vector.
10. An isolated cell, comprising the nucleic acid molecule according to claim 7 .
11. A composition, comprising
the recombinant hypoallergenic protein according to claim 1 ;
and an adjuvant, a pharmaceutically acceptable carrier, a preservative or a combination thereof.
12. The composition according to claim 11 , which comprises 10 ng to 1 g of said recombinant hypoallergenic protein.
13. The hypoallergenic protein according to claim 4 , wherein the human pathogenic virus is a picornavirus.
14. The composition according to claim 12 , wherein the viral protein is a capsid protein.
15. The composition according to claim 12 , wherein the virus protein is a human rhinovirus 89 protein or a human rhinovirus 14 protein.
16. The composition according to claim 11 , wherein the virus protein is a human pathogenic virus protein.
17. The recombinant hypoallergenic protein according to claim 1 , wherein the peptide is amino acids 1 to 33 of SEQ ID NO:10.
18. The recombinant hypoallergenic protein according to claim 1 , wherein the peptide is amino acids 2 to 31 of SEQ ID NO:12.
19. The recombinant hypoallergenic protein according to claim 1 , wherein the peptide is amino acids 2 to 38 of SEQ ID NO:14.
20. A method for treating a grass pollen allergy in a subject in in need thereof, the method comprising administering the recombinant hypoallergenic protein according to claim 1 .
21. A method for treating a grass pollen allergy in a subject in in need thereof, the method comprising administering the composition according to claim 11 .