IP Library › Granted Patent US 9,301,991
Granted Patent B2
US 9,301,991 · App. 14/069,790 · Granted Apr 5, 2016

sGCalphal inhibiting compositions

Inventors: Lirim Shemshedini (Ypsilanti, MI); Shao-Yong Chen (Brookline, MA); Changmeng Cai (Newton, MA); Chen-Lin Hsieh (Brighton, MA)
Assignee: The University of Toledo
A61K38/10A61K31/7048A61K38/06A61K38/07A61K38/08C07K5/081C07K5/1013C07K5/1016C07K5/1019C07K7/06C07K7/08C12N9/88C12Y406/01002A61K38/00
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Quick Facts
Patent No.
US 9,301,991
App. No.
14/069,790
Granted
Apr 5, 2016
Kind
B2
Abstract

The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.

Claims (4)

1. A composition of matter comprising a peptide consisting of the amino acid sequence of FF5-8R (SEQ ID NO: 10).

2. A pharmaceutical composition comprising: a composition of claim 1 ; and a pharmaceutically-acceptable carrier.

3. A composition of claim 1 , further comprising a chemotherapeutic agent.

4. A composition of claim 3 , wherein the chemotherapeutic agent is etoposide.

Assignments (2)
CONFIRMATORY LICENSE Recorded Mar 6, 2014
From: UNIVERSITY OF TOLEDO
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 032398/0428 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 1, 2013
From: SHEMSHEDINI, LIRIM; CHEN, SHAO-YONG; CAI, CHANGMENG; HSIEH, CHEN-LIN
To: THE UNIVERSITY OF TOLEDO
Reel/Frame 031529/0536 →
Continuity (3)
Continuation In Part 13375307
Provisional Application 61182712 · May 30, 2009
Related Publication 20140088023A1 · Mar 27, 2014