Substituted pyrazolo[3,4-D]pyrimidines and uses thereof
Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.
1. A compound having the formula:
wherein
R 1 and R 2 are independently hydrogen or substituted or unsubstituted alkyl;
R 3 is independently substituted or unsubstituted alkyl;
R 5 is independently
halogen, —CN, —CX a 3 , —S(O) 2 H, —NO, —NO 2 , —C(O)H, —C(O)NH 2 , —S(O) 2 NH 2 , —OH, —SH, —SO 2 Cl, —SO 3 H, —SO 4 H, —NHNH 2 , —ONH 2 , —NHC═(O)NHNH 2 , —NHC═(O)NH 2 , —NHSO 2 H, —NHC═(O)H, —NHC(O)—OH, —NHOH, —OCF 3 , —OCHF 2 , —CO 2 H, or substituted or unsubstituted (C 1 -C 6 ) alkyl;
R 6 is independently
halogen, —CN, —CX b 3 , —S(O) 2 H, —NO, —NO 2 , —C(O)H, —C(O)NH 2 , —S(O) 2 NH 2 , —OH, —SH, —SO 2 Cl, —SO 3 H, —SO 4 H, —NHNH 2 , —ONH 2 , —NHC═(O)NHNH 2 , —NHC═(O)NH 2 , —NHSO 2 H, —NHC═(O)H, —NHC(O)—OH, —NHOH, —OCF 3 , —OCHF 2 , or —CO 2 H;
L 1 is independently a bond or substituted or unsubstituted alkylene;
z1 is independently an integer from 0 to 4;
z2 is independently an integer from 2 to 5; and
X a and X b are independently —F, —Cl, —Br, or —I.
2. The compound of claim 1 , wherein R 1 is hydrogen.
3. The compound of claim 1 , wherein R 2 is hydrogen.
4. The compound of claim 1 , wherein L 1 is a bond.
5. The compound of claim 1 , wherein L 1 is methylene.
6. The compound of claim 1 , wherein R 3 is substituted or unsubstituted alkyl.
7. The compound of claim 1 , wherein R 5 is halogen, —CN, —CX a 3 , —NO, —NO 2 , —C(O)H, or —CO 2 H.
8. The compound of claim 1 , wherein R 6 is halogen, —CN, —CX b 3 , —NO, —NO 2 , —C(O)H, or —CO 2 H.
9. The compound of claim 1 , wherein R 6 is halogen.
10. The compound of claim 1 , wherein z1 is 0.
11. The compound of claim 1 , wherein z1 is 1.
12. The compound of claim 1 , wherein z2 is 2.
13. The compound of claim 1 , having the formula
wherein
R 4 is independently
halogen, —CN, —CX 3 , —S(O) 2 H, —NO, —NO 2 , —C(O)H, —C(O)NH 2 , —S(O) 2 NH 2 , —OH, —SH, —SO 2 Cl, —SO 3 H, —SO 4 H, —NHNH 2 , —ONH 2 , —NHC═(O)NHNH 2 , —NHC═(O) NH 2 , —NHSO 2 H, —NHC═(O)H, —NHC(O)—OH, —NHOH, —OCF 3 , —OCHF 2 , —CO 2 H, or substituted or unsubstituted (C 1 -C 6 ) alkyl;
y is independently an integer from 1 to 4; and
X is independently —F, —Cl, —Br, or —I.
14. The compound of claim 13 , wherein R 4 is halogen, —CN, —CX 3 , —NO, —NO 2 , —C(O)H, or —CO 2 H.
15. The compound of claim 13 , wherein y is 1.
16. A compound, having a formula selected from the group consisting of:
17. The compound of claim 15 , having a formula selected from the group consisting of:
18. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and the compound of claim 1 .
19. The pharmaceutical composition of claim 18 , further comprising an anti-cancer agent.