IP Library › Granted Patent US 9,321,827
Granted Patent B2
US 9,321,827 · App. 13/822,942 · Granted Apr 26, 2016

Factor VIII variants having a decreased cellular uptake

Inventors: Henriet Meems (Amsterdam, NL); Alexander Benjamin Meijer (Maarssen, NL); Koenraad Mertens (Leiden, NL); Ole Hvilsted Olsen (Broenshoej, DK); Kasper Lamberth (Stenloese, DK); Peder Lisby Noerby (Birkeroed, DK); Laust Bruun Johnsen (Skodsborg, DK); Marianne Hjortnæs Kjalke (Frederikssund, DK); Henning Ralf Stennicke (Kokkedal, DK); Johannes Voorberg (Jacobus, NL); Maartje Van Den Biggelaar (Amsterdam, NL)
Assignees: Novo Nordisk A/S; Sanquin Blood Supply Foundation
C07K14/755
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Quick Facts
Patent No.
US 9,321,827
App. No.
13/822,942
Granted
Apr 26, 2016
Kind
B2
Abstract

The present invention relates to modified coagulation factors. In particular, the present invention relates to modied Factor VIII molecules having decreased cellular uptake.

Claims (6)

1. A recombinant Factor VIII (FVIII) variant consisting of the amino acid sequence of SEQ ID NO: 9.

2. A pharmaceutical composition comprising the recombinant FVIII variant according to claim 1 .

3. A method for treating haemophilia comprising administering the recombinant FVIII variant according to claim 1 to a subject in need thereof.

4. A conjugate comprising the recombinant FVIII variant of claim 1 and a half-life extending agent selected from the group consisting of polyethylene glycol (PEG), poly sialic acid (PSA), and heparosan polymer (HEP).

5. A pharmaceutical composition comprising the conjugate according to claim 4 .

6. A method for treating haemophilia comprising administering the conjugate according to claim 4 to a subject in need thereof.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 17, 2018
From: NOVO NORDISK AS
To: SANQUIN BLOOD SUPPLY FOUNDATION
Reel/Frame 047199/0558 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 6, 2013
From: OLSEN, OLE HVILSTED; LAMBERTH, KASPER; NOERBY, PEDER LISBY; JOHNSEN, LAUST BRUUN; KJALKE, MARIANNE HJORTNES; STENNICKE, HENNING RALF
To: NOVO NORDISK A/S
Reel/Frame 031553/0860 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 6, 2013
From: MEEMS, HENRIET; MEIJER, ALEXANDER BENJAMIN; MERTENS, KOENRAAD; VOORBERG, JOHANNES JACOBUS; BIGGELAAR, MAARTJE VAN DEN
To: SANQUIN BLOOD SUPPLY FOUNDATION
Reel/Frame 031553/0902 →
Priority Claims (2)
EP 10176731 · Sep 15, 2010 · regional
EP 11173768 · Jul 13, 2011 · regional
Continuity (3)
Provisional Application 61384731 · Sep 21, 2010
Provisional Application 61507666 · Jul 14, 2011
Related Publication 20140057848A1 · Feb 27, 2014