Defensin-like molecules as novel antimicrobial agents
Disclosed are compositions and methods for treating and/or preventing infections in mammals, by administering to a mammal a therapeutically effective amount of at least one defensin-like molecule, e.g., in a composition that includes such molecule. Also disclosed are kits that include such molecules, or compositions that include such molecules, as well as instructions for using such molecules to treat a mammal.
1. A method of treating an infection in a mammal, comprising administering to the mammal a therapeutically effective amount of at least one molecule selected from the group consisting of
Compound D, BAS00127538 (Asinex, 3-PC-2)
and, derivatives, and analogs thereof, wherein said infection is caused by microorganisms comprising one or more gram-positive bacteria selected from the group consisting of Staphylococcus, Streptococcus , and Enterococcus.
2. The method of claim 1 , wherein said gram-positive bacteria comprises one or more bacteria selected from the group consisting of Staphylococcus aureus, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus anginosus group, Enterococcus faecalis, Enterococcus faecium , and Bacillus Anthracis.
3. The method of claim 1 , wherein said infection is sepsis.
4. A method of killing a bacterial population in a mammal comprising administering to a mammal infected with at least one bacterial population a therapeutically effective amount for killing the bacterial population, of at least one molecule selected from the group consisting of:
Compound D, BAS00127538 (Asinex, 3-PC-2)
and, derivatives, and analogs thereof, wherein said infection is caused by microorganisms comprising one or more gram-positive bacteria selected from the group consisting of Staphylococcus, Streptococcus , and Enterococcus.
5. The method of claim 4 , wherein the bacterial population comprises at least one bacteria selected from the group consisting of Staphylococcus aureus, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus anginosus group, Enterococcus faecalis, Enterococcus faecium , and Bacillus Anthracis.
6. The method of claim 4 , wherein the at least one compound is administered to the mammal as part of a composition.