Octahydrobenzoisoquinoline modulators of dopamine receptors and uses therefor
Octahydrobenzoisoquinoline modulators of dopamine receptors are described herein. Methods for using octahydrobenzoisoquinoline modulators of dopamine receptors in the treatment of dopamine dysfunction are also described herein.
1. A compound of the formula
or a pharmaceutically acceptable salt thereof, wherein:
R A is 7,8-dihydroxy;
R B is phenyl, optionally substituted with substituents selected from the group consisting of hydroxy, amino, and carboxylic acid; and
R N is hydrogen; and
wherein the chiral carbons have the following relative stereochemistry
2. A pharmaceutical composition comprising one or more compounds of claim 1 , and one or more pharmaceutically acceptable carriers, excipients, or diluents therefor.
3. The compound of claim 1 , wherein said compound is 5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[h]isoquinoline-7,8-diol, or a pharmaceutically acceptable salt thereof.
4. The compound of claim 3 , wherein said pharmaceutically acceptable salt is a HBr salt.