IP Library Granted Patent US 9,370,503
Granted Patent B1
US 9,370,503 · App. 14/632,866 · Granted Jun 21, 2016

Compounds for treating ocular diseases

Inventor: Chi Chou Liao (Taipei, TW)
A61K31/353A61K9/0048
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Quick Facts
Patent No.
US 9,370,503
App. No.
14/632,866
Granted
Jun 21, 2016
Kind
B1
Abstract

The present invention provides a method for treating an ocular disease in a subject in need thereof, comprising administering an effective amount of a compound of Formula (A) to the subject. Also provided is a pharmaceutical composition for treating an ocular disease, which comprises compound of Formula (A), and a pharmaceutically acceptable carrier.

Claims (7)

1. A method for treating an ocular disease other than an eye cancer in a subject in need thereof, comprising administering to the subject a pharmaceutical composition comprising an effective amount of a compound selected from the group consisting of:

2. The method of claim 1 , wherein the effective amount is an amount selected from the group consisting of: an amount effective to enhance the viability of RPE cells suffering from oxidative stress and/or hypoxia-induced damages; an amount effective to enhance the viability of RPE cells suffering from oxidative stress and/or hypoxia-induced damages, and in the same time having little or no effect on the viability of human umbilical vein endothelial cells (HUVECs) or effective to decrease the viability of HUVECs; an amount effective to enhance ocular blood flow; an amount effective to reduce choroidal neovascularization (CNV); an amount effective to enhance RPE function; and an amount effective in achieving a combination of the above-mentioned efficacies.

3. The method of claim 1 , wherein the ocular disease is selected from the group consisting of glaucoma, age-related macular degeneration (AMD), ischemic retinopathy, optic neuropathy, diabetic retinopathy, diabetic macular edema, uveitis, and senile cataract.

4. The method of claim 3 , wherein the ocular disease is AMD.

5. The method of claim 4 , wherein the AMD is dry AMD.

6. The method of claim 1 , wherein the pharmaceutical composition is administered to the subject topically in the eyes or orally.

7. The method of claim 1 , wherein the pharmaceutical composition is in the form of eye ointment, eye gel, eye cream, or eye drops.

Assignments (2)
MERGER AND CHANGE OF NAME Recorded Mar 23, 2018
From: SPRINGSKY BIOMED COMPANY LIMITED; NATUREWISE BIOTECH & MEDICALS CORPORATION
To: NATUREWISE BIOTECH & MEDICALS CORPORATION
Reel/Frame 045324/0867 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 19, 2017
From: LIAO, CHI CHOU
To: SPRINGSKY BIOMED LIMITED COMPANY
Reel/Frame 042059/0105 →