Antimicrobial compositions and methods of use

1. An antimicrobial composition, comprising:

a) 6-amino-2-ketohexanoic acid; and

b) a source of hydrogen peroxide;

wherein the composition has a pH of from about 3 to about 8;

the concentration of 6-amino-2-ketohexanoic acid is from about 15 mM to about 30 mM in the final composition; the concentration of the hydrogen peroxide obtained from the source of hydrogen peroxide is from about 0.5 mM to about 10 mM in the final composition; and provided the concentration of the 6-amino-2-ketohexanoic acid and source of hydrogen peroxide are not the same.

2. The composition according to claim 1 , wherein the pH is from about 5 to about 7.

3. The composition according to claim 1 , wherein the pH is from about 5 to about 6.

4. The composition according to claim 1 , wherein the pH is from about 4.5 to about 5.5.

5. The composition according to claim 1 , wherein the pH is about 5.

6. The composition according to claim 1 , wherein the pH is about 6.

7. The composition according to claim 1 , wherein the concentration of 6-amino-2-ketohexanoic acid is from about 20 mM to about 30 mM in the final composition.

8. The composition according to claim 1 , wherein the concentration of 6-amino-2-ketohexanoic acid is from about 25 mM to about 30 mM in the final composition.

9. The composition according to claim 1 , wherein the concentration of hydrogen peroxide is from about 0.5 mM to about 7 mM in the final composition.

10. The composition according to claim 1 , wherein the concentration of hydrogen peroxide is from about 1 mM to about 5 mM in the final composition.

11. The composition according to claim 1 , wherein the concentration of hydrogen peroxide is from about 1 mM to about 4 mM in the final composition.

12. The composition according to claim 1 , wherein the concentration of hydrogen peroxide is from about 2 mM to about 5 mM in the final composition.

13. A composition according to claim 1 , further comprising a surfactant.

14. A composition according to claim 1 , further comprising a stabilizer.

15. A composition according to claim 1 , further comprising a buffer system.

16. A composition comprising:

A) a first component in the form of a concentrate comprising from about 0.01% by weight to about 90% by weight of 6-amino-2-ketohexanoic acid; and

B) a second component containing a source of hydrogen peroxide, comprising:

a) from about 0.01% by weight to about 30% by weight of hydrogen peroxide;

b) from about 0.01% to about 50% by weight of a stabilizing system; and

c) a carrier;

wherein when components (A) and (B) are combined the concentration of 6-amino-2-ketohexanoic acid is from about 15 mM to about 30 mM in the final composition; and

the concentration of hydrogen peroxide is from about 0.5 mM to about 10 mM in the final composition.

17. The composition according to claim 16 , wherein the concentration of 6-amino-2-ketohexanoic acid is from about 20 mM to about 30 mM in the final composition.

18. The composition according to claim 16 , wherein the concentration of 6-amino-2-ketohexanoic acid is from about 25 mM to about 30 mM in the final composition.

19. The composition according to claim 16 , wherein the concentration of hydrogen peroxide is from about 1 mM to about 5 mM in the final composition.

20. The composition according to claim 16 , wherein the concentration of hydrogen peroxide is from about 1 mM to about 4 mM in the final composition.

21. The composition according to claim 16 , wherein the concentration of hydrogen peroxide is from about 2 mM to about 5 mM in the final composition.

22. A composition comprising:

A) a first component in the form of a solid concentrate comprising from about 0.01% by weight to about 100% by weight of 6-amino-2-ketohexanoic acid and

B) a second component, comprising:

a) hydrogen peroxide;

b) a stabilizing system; and

c) a carrier;

wherein when components (A) and (B) are combined the concentration of 6-amino-2-ketohexanoic acid is from about 15 mM to about 30 mM in the final composition; and the concentration of hydrogen peroxide is from about 0.5 mM to about 10 mM in the final composition.

23. An antimicrobial composition, comprising:

a) from about 4 g to about 6 g of 6-amino-2-ketohexanoic acid;

b) 5.7 mL of a 3% solution of hydrogen peroxide; and

c) citric acid/sodium citrate buffer;

wherein the composition has a pH about 5.5.

24. An antimicrobial composition, comprising:

a) one or more α-keto acids having the formula:

wherein R 1 is a nitrogen atom comprising unit chosen from:

i) —NR 3a R 3b ;

ii) —NR 4 C(═R 5 )R 6 ;

iii) —NR 7 NR 8a R 8b ;

iv) —N═R 9 ; or

v) —C(═NR 10 )R 11 ;

R 3a and R 3b are each independently chosen from:

i) hydrogen;

ii) C 1 -C 4 linear, C 3 -C 4 branched or C 3 -C 4 cyclic alkyl; or

iii) hydroxyl;

R 4 is:

i) hydrogen; or

ii) C 1 -C 4 linear, C 3 -C 4 branched or C 3 -C 4 cyclic alkyl;

R 5 is:

i) O;

ii) S; or

iii) NR 12 ; R 12 is hydrogen, hydroxyl, or C 1 -C 4 linear, C 3 -C 4 branched or C 3 -C 4 cyclic alkyl;

R 6 is:

i) hydrogen;

ii) C 1 -C 4 linear, C 3 -C 4 branched or C 3 -C 4 cyclic alkyl;

iii) C 1 -C 4 linear, C 3 -C 4 branched or C 3 -C 4 cyclic alkoxy; or

iv) —NR 13a R 13b ; R 13a and R 13b are each independently hydrogen or C 1 -C 4 linear, C 3 -C 4 branched or C 3 -C 4 cyclic alkyl;

R 7 , R 8a , and R 8b are each independently chosen from:

i) hydrogen; or

ii) C 1 -C 4 linear, C 3 -C 4 branched or C 3 -C 4 cyclic alkyl;

R 9 is:

i) NR 14 ; or

ii) CR 15a R l5b ;

R 14 , R 15a , and R 15b are each independently chosen from:

i) hydrogen; or

ii) C 1 -C 4 linear, C 3 -C 4 branched or C 3 -C 4 cyclic alkyl;

R 10 is hydrogen, hydroxyl, or C 1 -C 4 linear, C 3 -C 4 branched or C 3 -C 4 cyclic alkyl;

R 11 is chosen from:

i) NR 16 ; or

ii) CR 17a R l7b ;

R 16 is hydrogen or C 1 -C 4 linear, C 3 -C 4 branched or C 3 -C 4 cyclic alkyl;

R 17a and R 17b are each independently chosen from:

i) hydrogen; or

ii) C 1 -C 4 linear, C 3 -C 4 branched or C 3 -C 4 cyclic alkyl;

R 2a and R 2b are each independently chosen from:

i) hydrogen; or

ii) C 1 -C 4 linear, C 3 -C 4 branched or C 3 -C 4 cyclic alkyl;

the index x is an integer from 1 to 10; and

M is hydrogen or a water soluble cation; and

b) a source of hydrogen peroxide;

wherein the composition has a pH of from about 3 to about 8;

provided the concentration of the one or more α-keto acids and source of hydrogen peroxide are not the same.

25. A method for providing antimicrobial protection to a situs, comprising contacting the situs in need of protection against microorganisms with a composition according to claim 1 .

26. A method for sanitizing a situs, comprising contacting the situs with a composition according to claim 1 .

27. A method for disinfecting a situs, comprising contacting the situs with a composition according to claim 1 .

28. A method for controlling biofilms on a situs, comprising contacting the situs with a composition according to claim 1 .

29. A method according to claim 25 , wherein the situs is human or animal tissue.

30. A method according to claim 25 , wherein the situs is a hard surface.

31. A medical composition comprising a composition according to claim 1 and an effective amount of a pharmaceutically active agent.