Polymer films
Biodegradable, cross-linked polymer films and methods of making the same are described. The polymer films can be used for preventing adhesions following surgery and/or delivering therapeutic agents.
1. A polymer film comprising:
at least one monomer including at least one functional group; and
at least one crosslinker selected from bis-glycidyl amino alcohol, bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate,
wherein a, b, c, d, e, and f are each independently 1-20;
wherein the polymer film has a thickness between about 40 μm and about 1,200 μm and is biodegradable.
2. The polymer film of claim 1 , wherein the polymer film has a shape selected from a circle, square, rectangle, triangle, ellipse, or pentagon.
3. The polymer film of claim 1 , wherein the at least one functional group is acrylate, acrylamide, methacrylate, or methacrylamide.
4. The polymer film of claim 1 , wherein the at least one monomer includes an ionizable functional group.
5. The polymer film of claim 4 , wherein the ionizable functional group is basic.
6. The polymer film of claim 4 , wherein the ionizable functional group is acidic.
7. The polymer film of claim 1 , wherein the at least one crosslinker includes at least two functional groups.
8. The polymer film of claim 1 , wherein the crosslinker includes at least one linkage susceptible to degradation through hydrolysis or enzymatic action.
9. The polymer film of claim 8 , wherein the at least one linkage is an ester, a thioester, a carbonate, a carbamate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenase, a peptide cleavable by matrix elastase, a peptide cleavable by matrix cathepsin, or a combination thereof.
10. The polymer film of claim 9 , including a second crosslinker including a second linkage selected from an ester, a thioester, a carbonate, a carbamate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins.
11. The polymer film of claim 1 , wherein the polymer film is substantially degraded within about 6 months of implantation.
12. The polymer film of claim 1 , wherein the polymer film is substantially degraded within about 1 month of implantation.
13. The polymer film of claim 1 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bis-glycidyl amino alcohol.
14. The polymer film of claim 1 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate.
15. A method of making a polymer film comprising:
reacting a prepolymer solution including at least one monomer including at least one functional group, at least one crosslinker susceptible to degradation, and an initiator; and
forming the polymer film, wherein the polymer film has a thickness between about 40 μm and about 1,200 μm,
wherein the at least one crosslinker is selected from bis-glycidyl amino alcohol, bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate,
wherein a, b, c, d, e, and f are each independently 1-20.
16. The method of claim 15 , wherein the film is formed between two plates including at least one spacer.
17. The method of claim 15 , wherein the initiator is N,N,N′,N′-tetramethylethylenediamine.
18. The method of claim 15 , wherein the polymer film has a shape selected from a circle, square, rectangle, triangle, ellipse, or pentagon.
19. The method of claim 15 , wherein the at least one functional group is acrylate, acrylamide, methacrylate, or methacrylamide.
20. The method of claim 15 , wherein the polymer film is biodegradable.
21. The method of claim 20 , wherein the polymer film is substantially degraded within about 1 month of implantation.
22. The method of claim 20 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bis-glycidyl amino alcohol.
23. The method of claim 20 , wherein the at least one monomer is acrylamide and the at least one crosslinker is bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate.