Compounds for the treatment of autism
A compound which inhibits the importation of chloride into neurons and a compound which improve the outflow of chloride from neurons for the use in treatment of autism, a pharmaceutical composition for use in the treatment of autism including such compound and a pharmaceutically acceptable carrier are described.
1. A method for treating autism in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound which is a Na—K—Cl co-transporter (NKCC) inhibitor and a loop diuretic, wherein said compound is bumetanide.
2. The method according to claim 1 , wherein the compound is administered at a dosage level from 0.0002 mg/kg to about 20 mg/kg of body weight per day.
3. The method according to claim 1 , wherein the subject in need thereof is a child showing signs of autism.