Pharmaceutical products from fungal strains
Disclosed herein are compositions comprising an isolated cellulose degrading fungus and pharmaceutical substances produced by the fungus.
1. An antibacterial composition comprising:
(i) an effective amount of an inhibitory substance obtained from a conditioned medium, and
(ii) a solution consisting of 20% isopropanol and 80% methylene chloride;
wherein the inhibitory substance is in an amount that effectively inhibits the growth of gram-positive and gram-negative bacteria; and wherein said conditioned medium is prepared by a process comprising the steps of:
a) incubating a cellulose degrading fungus of the genus Penicillium having all the identifying characteristics of NRRL deposit Accession No: 50410 in a liquid medium for a sufficient time to produce the inhibitory substance; and
b) separating the fungus from the liquid medium, thereby producing said conditioned medium.
2. The conditioned medium of claim 1 , wherein said inhibitory substance is a bacteriostatic agent.
3. The conditioned medium of claim 1 , wherein said inhibitory substance is a bacteriocidal agent.
4. The composition of claim 1 , wherein the conditioned medium is liquid medium comprising a feedstock of Sorghum stalk in 1× recycled sorghum stalk broth without glycerol.