Process for making hydroxylated cyclopentylpyrimidine compounds
The invention provides processes for preparing a compound of formula I and salts thereof, wherein R 1 is defined herein, and compounds and intermediates of said formula.
1. A compound of formula IV:
or a salt thereof, wherein:
R 2 is —CN, —COOR a or —CONR a R b ;
R a and R b are independently hydrogen, —OR c , substituted or unsubstituted C 1-12 alkyl, substituted or unsubstituted C 2-12 alkenyl, substituted or unsubstituted C 2-12 alkynyl, substituted or unsubstituted C 3-8 cycloalkyl, substituted or unsubstituted phenyl or substituted or unsubstituted 3 to 12 membered heterocyclyl; or
R a and R b are taken together with the atom to which they are attached to form a 3-7 membered heterocyclyl;
R c is independently hydrogen or optionally substituted C 1-12 alkyl; and
each R 3 is independently iodo or bromo.
2. The compound of claim 1 , wherein R 2 is —C(O)N(R a )OR c .
3. The compound of claim 1 , wherein each R 3 is iodo.
4. The compound of claim 1 , which is the compound: