Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
View Patent ↗The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R 1 , X, Y, Z, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 18 , R 19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
1. A compound, or a pharmaceutically acceptable salt thereof, selected from the group consisting of:
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2. A pharmaceutical composition comprising at least one compound according claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
3. The pharmaceutical composition of claim 2 , further comprising at least one additional therapeutic agent selected from the group consisting of: an HCV polymerase inhibitor, an interferon, a viral replication inhibitor, an antisense agent, a therapeutic vaccine, a viral protease inhibitor, a virion production inhibitor, an immunosuppressive agent, an antiviral antibody, a CYP-450 inhibitor, an antiviral booster, and an antiviral sensitizer.
4. The pharmaceutical composition according to claim 2 , further comprising therapeutically effective amounts of pegylated interferon and ribavirin.
5. A method of treating an HCV infection comprising administering to a patient in need of such treatment a therapeutically effective amount of at least one compound according to claim 1 , or a pharmaceutically acceptable salt thereof.
6. The method according to claim 5 , further comprising administering a therapeutically effective amount of at least one additional therapeutic agent useful for treating a viral infection or a virus-related disorder, wherein said at least one additional therapeutic agent is selected from the group consisting of: an HCV polymerase inhibitor, an interferon, a viral replication inhibitor, an antisense agent, a therapeutic vaccine, a viral protease inhibitor, a virion production inhibitor, an immunosuppressive agent, an antiviral antibody, a CYP-450 inhibitor, an antiviral booster, and an antiviral sensitizer.
7. The method according to claim 5 , further comprising administering therapeutically effective amounts of pegylated interferon and ribavirin.