Polysaccharides from prasinococcales
There is provided a composition comprising a polysaccharide obtainable from the microalgae, Prasinococcus capsulatus and strains related to P. capsulatus for use prophylactically and/or therapeutically in the treatment of disorders of the immune system, for example in psoriasis and dermatological conditions, internal immune system disorders, in particular gut inflammatory conditions and respiratory conditions. Further, there is provided derivatives of a polysaccharide obtainable from the microalgae, Prasinococcus capsulatus or an algal strain related to P. capsulatus and the use of such derivatives prophylactically and/or therapeutically in the treatment of disorders of the immune system.
1. An oligosaccharide derivative of a gel forming polysaccharide, wherein the polysaccharide is obtainable from microalgal cells from the order Prasinococcus capsulatus wherein the gel forming polysaccharide is a sulfated heteropolymer of molecular weight of at least 670 kDa comprising glucose, galactose, arabinose and uronic acid units, wherein said derivative has a molecular weight in the range of about 2 kDa to 60 kDa.
2. A derivative as claimed in claim 1 wherein the derivative has a molecular weight in the range 2 to 10 kDa.
3. A derivative as claimed in claim 2 wherein the derivative comprises by weight about
30 to 40% Glucose
30 to 40% Galactose
8 to 14% Arabinose
7 to 11% Uronic acid
and 1 to 10% of other sugar units.
4. A derivative as claimed in claim 1 wherein the derivative has a molecular weight in the range 20 to 60 kDa.
5. A derivative as claimed in claim 4 wherein the derivative comprises by weight about
25 to 28% Glucose
35 to 55% Galactose
8 to 17% Arabinose
4-6% Uronic acids
and 1 to 5% of other sugar units.
6. A derivative as claimed in claim 1 wherein the derivative inhibits neutrophil elastase release by about 70 to 90%.
7. A derivative as claimed in claim 1 wherein the derivative inhibits neutrophil reactive oxygen species production by about 30-40% relative to neutrophils to which derivative has not been provided.
8. A derivative as claimed in claim 1 wherein the derivative inhibits human keratinocyte IL-8 gene expression and IL8 release by about 70 to 100% relative to keratinocyte to which derivative has not been provided.
9. A composition comprising a derivative, as claimed in claim 1 .
10. A cosmetic preparation comprising a derivative as claimed in claim 1 .
11. A nutritional supplement comprising a derivative as claimed in claim 1 .
12. A method for prophylaxis or treatment of an immune system disorder comprising administering the derivative of claim 1 to an animal in need thereof.
13. The method of claim 12 wherein said immune system disorder is an inflammatory skin condition selected from the group consisting of eczema, psoriasis and atopic dermatitis.
14. The method of claim 12 wherein said immune system disorder is an inflammatory condition of the gut selected from the group consisting of irritable bowel syndrome, Crohn's disease and ulcerative colitis.
15. The method of claim 12 wherein said immune system disorder is an inflammatory condition of the respiratory system selected from the group consisting of asthma, cystic fibrosis, emphysema, chronic obstructive pulmonary disorder, acute respiratory distress syndrome, and allergic rhinitis.