IP Library › Granted Patent US 9,458,152
Granted Patent B2
US 9,458,152 · App. 14/920,833 · Granted Oct 4, 2016

Bicyclic sulfonamide compounds as sodium channel inhibitors

Inventors: Matthew Weiss (Boston, MA); Alessandro Boezio (Somerville, MA); Christiane Boezio (Somerville, MA); John R. Butler (Somerville, MA); Margaret Yuhua Chu-Moyer (Brookline, MA); Erin F. Dimauro (Cambridge, MA); Thomas Dineen (Somerville, MA); Russell Graceffa (Hampton, NH); Angel Guzman-Perez (Belmont, MA); Hongbing Huang (Brighton, MA); Charles Kreiman (Hopkinton, MA); Daniel La (Brookline, MA); Isaac E. Marx (Arlington, MA); Benjamin Charles Milgram (Cambridge, MA); Hanh Nho Nguyen (Jupiter, FL); Emily Anne Peterson (Cambridge, MA); Karina R. Vaida (Burlington, MA); Brian Sparling (Watertown, MA)
Assignee: Amgen Inc.
C07D417/14C07C53/18C07D215/227C07D215/36C07D241/44C07D401/12C07D401/14C07D403/12C07D413/12C07D413/14C07D417/12C07D471/04
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Quick Facts
Patent No.
US 9,458,152
App. No.
14/920,833
Granted
Oct 4, 2016
Kind
B2
Abstract

The present invention provides compounds of Formula I, and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders and itch. Also provided are pharmaceutical compositions containing compounds of the present invention.

Claims (673)

1. A compound of Formula I, or a pharmaceutically acceptable salt thereof,

wherein:

wherein each R a is independently H, halo, —OH, —NR b R b , —C 1-6 alkyl, —OC 1-6 alkyl, —C 1-6 haloalkyl, —OC 1-6 haloalkyl or —CN, and

R 1 is a 5 to 10 membered aryl or heteroaryl, wherein the heteroaryl group can have from 1 to 3 heteroatoms independently selected from O, N or S, and the aryl or heteroaryl group can be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —NR b R b , —C 1-6 alkyl, —OC 1-6 alkyl, —OC 1-6 alkylCF 3 , —OC 1-6 alkylCN, —C 1-6 alkylOC 1-6 alkyl, —(SO 2 )C 1-6 alkyl, —(SO 2 )NR b R b , hydroxyC 1-6 alkyl, —CF 3 , —CHF 2 , —CH 2 F, —OCF 3 , —OCHF 2 , —OCH 2 F, —(CR e R e ) m CN, —C(═O)NR b R b , —C(═O)OR b , —N(CR e R e ) m A, —N(R e )(CR e R e ) m A, —(C═N)OC 1-6 alkyl, —(C═O)N(R e )(CR e R e ) m A, (C═O)N(R e )(CR e R e ) m CF 3 , —O(CR e R e ) m A, —O(CR e R e ) m OA or —C(═O)A;

A is a 4 to 9 membered aryl, heteroaryl or heterocycloalkyl group, where the heteroaryl or heterocycloalkyl group can have from 1 to 3 heteroatoms independently selected from O, N or S, or a 3 to 6 membered cycloalkyl group, and the aryl, heteroaryl, heterocycloalkyl or cycloalkyl group can be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —NR b R b , —C 1-6 alkyl, —OC 1-6 alkyl, —(CR e R e ) m OH, hydroxyC 1-6 alkyl, —CF 3 , —CHF 2 , —CH 2 F, —OCF 3 , —OCHF 2 , —OCH 2 F, —CN, —C(═O)NR b R b , —O(CR e R e ) m B or —(CR e R e ) m B;

B is a 5 to 6 membered aryl, heteroaryl or heterocycloalkyl group, where the heteroaryl or heterocycloalkyl group can have from 1 to 3 heteroatoms independently selected from O, N or S, or a 3 to 5 membered cycloalkyl group, and the aryl, heteroaryl, cycloalkyl or heterocycloalkyl group can be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —NR b R b , —C 1-6 alkyl, —OC 1-6 alkyl, hydroxyC 1-6 alkyl, —CF 3 , —CHF 2 , —CH 2 F, —OCF 3 , —OCHF 2 , —OCH 2 F, —CN or —C(═O)NR b R b ;

R 2 is a 5 to 10 membered aryl or heteroaryl, where the heteroaryl group can have from 1 to 3 heteroatoms independently selected from O, N or S, and the aryl or heteroaryl group can be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —NR b R b , —C 1-6 alkyl, —OC 1-6 alkyl, hydroxyC 1-6 alkyl, —(CR c R c ) n NR b R b , —CF 3 , —CHF 2 , —CH 2 F, —OCF 3 , —OCHF 2 , —OCH 2 F, —CN or —C(═O)NR b R b ;

each R b is independently H or —C 1-6 alkyl;

each R c is independently H or —C 1-6 alkyl; and

each R d is independently H, halo, —CN, —NR c R c , —OH, —C 1-6 alkyl, —C 1-6 haloalkyl, —OC 1-6 haloalkyl or —OC 1-6 alkyl;

each R e is independently H, halo, —CN, —NR c R c , —OH, —C 1-6 alkyl, —OC 1-6 alkyl or a 5 to 6 membered heterocycloalkyl group having from 1 to 3 heteroatoms independently selected from O, N or S;

each n is independently 0, 1, 2, 3 or 4;

each m is independently 0, 1, 2, 3 or 4.

2. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R d is independently H, F or Cl.

3. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is a 6 membered aryl or heteroaryl group, where the heteroaryl group can have from 1 to 3 heteroatoms independently selected from O, N or S, and the aryl or heteroaryl group can be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —C 1-6 alkyl, —OC 1-6 alkyl, hydroxyC 1-6 alkyl, —CF 3 , —CHF 2 , —CH 2 F, —OCF 3 , —OCHF 2 , —OCH 2 F, CN, —C(═O)NR b R b , —C(═O)OR b , —OA or A; and

A is a 5 to 6 membered aryl or heteroaryl group, wherein the heteroaryl group can have from 1 to 3 heteroatoms independently selected from O, N or S, and the aryl or heteroaryl group can be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —C 1-6 alkyl, —OC 1-6 alkyl, hydroxyC 1-6 alkyl —CF 3 , —CHF 2 , —CH 2 F, —OCF 3 , —OCHF 2 , —OCH 2 F, —CN, or —C(═O)NR b R b .

4. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is a phenyl ring or pyridyl ring, wherein the ring can be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —C 1-6 alkyl, —OC 1-6 alkyl, hydroxyC 1-6 alkyl, —CF 3 , —CHF 2 , —CH 2 F, —OCF 3 , —OCHF 2 , —OCH 2 F, CN, —C(═O)NR b R b , —C(═O)OR b , —OA or A.

5. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, wherein A is a ring selected from cyclopropyl, cyclopentyl, cyclohexyl, piperidinyl, piperazinyl, pyrrolidinyl, azetidinyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, wherein the ring can be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —C 1-6 alkyl, —OC 1-6 alkyl, hydroxyC 1-6 alkyl —CF 3 , —CHF 2 , —CH 2 F, —OCF 3 , —OCHF 2 , —OCH 2 F, —CN, or —C(═O)NR b R b .

6. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, wherein

R 1 is a phenyl ring or pyridyl ring, wherein the ring can be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —C 1-6 alkyl, —OC 1-6 alkyl, hydroxyC 1-6 alkyl, —CF 3 , —CHF 2 , —CH 2 F, —OCF 3 , —OCHF 2 , —OCH 2 F, CN, —C(═O)NR b R b —C(═O)OR b , —OA or A; and

A is a ring selected from cyclopropyl, cyclopentyl, cyclohexyl, piperidinyl, piperazinyl, pyrrolidinyl, azetidinyl, pyridyl, pyrimidinyl, pyrazolyl, pyridazolyl, wherein the ring can be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —C 1-6 alkyl, —OC 1-6 alkyl, hydroxyC 1-6 alkyl —CF 3 , —CHF 2 , —CH 2 F, —OCF 3 , —OCHF 2 , —OCH 2 F, —CN, or —C(═O)NR b R b .

7. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, wherein A is a ring selected from cyclopropyl or cyclohexyl, wherein the ring can be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —C 1-6 alkyl, —OC 1-6 alkyl, hydroxyC 1-6 alkyl —CF 3 , —CHF 2 , —CH 2 F, —OCF 3 , —OCHF 2 , —OCH 2 F, —CN, or —C(═O)NR b R b .

8. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is a phenyl ring that can be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —C 1-6 alkyl, —OC 1-6 alkyl, hydroxyC 1-6 alkyl, —CF 3 , —CHF 2 , —CH 2 F, —OCF 3 , —OCHF 2 , —OCH 2 F, CN, —C(═O)NR b R b , —C(═O)OR b , —OA or A; and

A is a ring selected from cyclopropyl, cyclohexyl, piperidinyl, pyrrolidinyl, azetidinyl, pyridyl, pyrimidinyl, wherein the ring can be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —C 1-6 alkyl, —OC 1-6 alkyl, hydroxyC 1-6 alkyl —CF 3 , —CHF 2 , —CH 2 F, —OCF 3 , —OCHF 2 , —OCH 2 F, —CN or —C(═O)NR b R b .

9. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is a 5 to 6 membered aryl or heteroaryl, where the heteroaryl can have from 1 to 3 heteroatoms independently selected from O, N or S, and the aryl or heteroaryl can be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —NR b R b , —C 1-6 alkyl, —OC 1-6 alkyl, hydroxyC 1-6 alkyl, —(CR c R c ) n NR b R b , —CF 3 , —CHF 2 , —CH 2 F, —OCF 3 , —OCHF 2 , —OCH 2 F, —CN or —C(═O)NR b R b .

10. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is thiadiazolyl, substituted thiadiazolyl, thiazolyl, substituted thiazolyl, oxazolyl, substituted oxazolyl, oxadiazolyl, substituted oxadiazolyl, pyrimidinyl, substituted pyrimidinyl, isoxazolyl, substituted isoxazolyl, pyrazolyl, substituted pyrazolyl, pyridyl, substituted pyridyl, pyridazinyl, substituted pyridazinyl, pyrazinyl or substituted pyrazinyl.

11. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is thiadiazolyl.

12. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is pyrimidinyl.

13. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is thiazolyl.

14. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is substituted oxazolyl.

15. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is isoxazolyl.

16. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R d is independently H.

17. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, selected from:

COMPOUND NAME

COMPOUND STRUCTURE

1-(5-FLUORO-2-METHOXY-4- NEOPENTYLPHENYL)-N- (ISOXAZOL-3-YL)-2-OXO-1,2- DIHYDROQUINOLINE-6- SULFONAMIDE

(P)-1-(4-BROMO-2-METHOXY-5- METHYLPHENYL)-N-3- ISOXAZOLYL-2-OXO-1,2-DIHYDRO- 6-QUINOLINESULFONAMIDE (415) AND (M)-1-(4-BROMO-2-METHOXY- 5-METHYLPHENYL)-N-3- ISOXAZOLYL-2-OXO-1,2-DIHYDRO- 6-QUINOLINESULFONAMIDE (416)

(P)-1-(2-METHOXY-4- (TRIFLUOROMETHYL)PHENYL)- 2-OXO-N-(THIAZOL-2-YL)-1,2- DIHYDROQUINOLINE-6- SULFONAMIDE (463)

(M)-1-(2-METHOXY-4- (TRIFLUOROMETHYL)PHENYL)- 2-OXO-N-(THIAZOL-2-YL)-1,2- DIHYDROQUINOLINE-6- SULFONAMIDE (464)

(P)-1-(4-BROMO-5-CHLORO-2- METHOXYPHENYL)-N-(ISOXAZOL- 3-YL)-2-OXO-1,2- DIHYDROQUINOLINE-6- SULFONAMIDE (473); and (M)-1-(4- BROMO-5-CHLORO-2- METHOXYPHENYL)-N-(ISOXAZOL- 3-YL)-2-OXO-1,2- DIHYDROQUINOLINE-6- SULFONAMIDE (474)

1-(4-BROMO-2-(CYANOMETHOXY)- 5-FLUOROPHENYL)-N-(ISOXAZOL-3- YL)-2-OXO-1,2- DIHYDROQUINOLINE-6- SULFONAMIDE

1-(5-CHLORO-6- (CYCLOPROPYLMETHOXY)-2- METHOXY-3-PYRIDINYL)-N-3- ISOXAZOLYL-2-OXO-1,2-DIHYDRO- 6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2- METHOXYPHENYL)-N-(4,5- DIMETHYL-3-ISOXAZOLYL)- 2-OXO-1,2-DIHYDRO-6- QUINOLINESULFONAMIDE

(P)-1-(4-(CYCLOHEXYLMETHYL)- 5- FLUORO-2-METHOXYPHENYL)- 2-OXO-N-2-PYRIMIDINYL-1,2- DIHYDRO-6- QUINOLINESULFONAMIDE

(P)-1-(4-(CYCLOHEXYLMETHYL)- 5- FLUORO-2-METHOXYPHENYL)-N- 1,2,4-OXADIAZOL-3-YL-2-OXO-1,2- DIHYDRO-6- QUINOLINESULFONAMIDE

1-(5-CHLORO-6- (CYCLOPENTYLAMINO)-2- METHOXY-3-PYRIDINYL)-N-3- ISOXAZOLYL-2-OXO-1,2- DIHYDRO-6- QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2- METHOXYPHENYL)-N-(2- METHYLPYRIMIDIN-4-YL)-2- OXO-1,2-DIHYDROQUINOLINE- 6-SULFONAMIDE

(P)-1-(5-CHLORO-2-METHOXY- 4-(TRIFLUOROMETHYL)PHENYL)- 2-OXO-N-(PYRIMIDIN-4-YL)-1,2- DIHYDROQUINOLINE-6- SULFONAMIDE (656) AND (M)-1- (5-CHLORO-2-METHOXY-4- (TRIFLUOROMETHYL)PHENYL)- 2-OXO-N-(PYRIMIDIN-4-YL)-1,2- DIHYDROQUINOLINE-6- SULFONAMIDE (657)

1-(4-BROMO-2-(1-CYANOETHOXY)- 5-FLUOROPHENYL)-N-(ISOXAZOL- 3-YL)-2-OXO-1,2- DIHYDROQUINOLINE-6- SULFONAMIDE

1-(5-BROMO-2-METHOXYPHENYL)- N-3-ISOXAZOLYL-2-OXO-1,2- DIHYDRO-6- QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-4- (TRIFLUOROMETHYL)PHENYL)- 2-OXO-N-4-PYRIMIDINYL-1,2- DIHYDRO-6- QUINOLINESULFONAMIDE

1-(5-(CYANOMETHYL)-2- METHOXYPHENYL)-N-3- ISOXAZOLYL-2-OXO-1,2- DIHYDRO-6- QUINOLINESULFONAMIDE

N-(ISOXAZOL-3-YL)-1-(2- METHOXYPHENYL)-2- OXO-1,2- DIHYDROQUINOLINE-6- SULFONAMIDE

18. The compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof, selected from:

COMPOUND NAME

1-(5-CHLORO-6-(3,3-DIFLUOROAZETIDIN-1-YL)-2-METHOXYPYRIDIN-3-YL)-N-

(ISOXAZOL-3-YL)-2-OXO-1,2-DIHYDROQUINOLINE-6-SULFONAMIDE

N-3-ISOXAZOLYL-1-(2-METHOXY-5-(4-PYRIDINYL)PHENYL)-2-OXO-1,2-

DIHYDRO-6-QUINOLINESULFONAMIDE

N-3-ISOXAZOLYL-1-(2-METHOXY-5-(2-PYRIDINYL)PHENYL)-2-OXO-1,2-

DIHYDRO-6-QUINOLINESULFONAMIDE

N-3-ISOXAZOLYL-1-(2-METHOXY-5-(1-METHYL-1H-PYRAZOL-5-YL)PHENYL)-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(3-PYRIDINYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(3,3-DIFLUORO-1-AZETIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(5-CHLORO-3-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE (407), (P)-1-(4-(5-

CHLORO-3-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE (408) and (M)-1-(4-(5-CHLORO-3-

PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-

DIHYDRO-6-QUINOLINESULFONAMIDE (409)

1-(5-FLUORO-2-METHOXY-4-(1-METHYL-1H-IMIDAZOL-4-YL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(M)-1-(4-(5-FLUORO-2-METHOXY-3-PYRIDINYL)-2-METHOXY-5-

METHYLPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE (425) and (P)-1-(4-(5-FLUORO-2-METHOXY-3-

PYRIDINYL)-2-METHOXY-5-METHYLPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-

DIHYDRO-6-QUINOLINESULFONAMIDE (426)

1-(4-CYCLOPENTYL-5-FLUORO-2-METHOXYPHENYL)-N-(ISOXAZOL-3-YL)-2-

OXO-1,2-DIHYDROQUINOLINE-6-SULFONAMIDE

1-(5-(5-FLUORO-3-PYRIDINYL)-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

N-3-ISOXAZOLYL-1-(2-METHOXY-5-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL)-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-(6-FLUORO-3-PYRIDINYL)-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-(5-FLUORO-2-METHOXY-3-PYRIDINYL)-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

N-3-ISOXAZOLYL-1-(2-METHOXY-5-(5-PYRIMIDINYL)PHENYL)-2-OXO-1,2-

DIHYDRO-6-QUINOLINESULFONAMIDE

N-3-ISOXAZOLYL-1-(2-METHOXY-5-(3-PYRIDINYL)PHENYL)-2-OXO-1,2-

DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-(5-CYANO-3-PYRIDINYL)-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

N-3-ISOXAZOLYL-1-(2-METHOXY-5-(5-(TRIFLUOROMETHYL)-3-

PYRIDINYL)PHENYL)-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-(5-CHLORO-3-PYRIDINYL)-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-(2-FLUORO-3-PYRIDINYL)-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-(2-FLUORO-4-PYRIDINYL)-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-FLUORO-5-(6-FLUORO-3-PYRIDINYL)-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-6-ISOQUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(6-METHYL-3-PYRIDINYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(4-PYRIDINYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(3-(TRIFLUOROMETHYL)-1-AZETIDINYL)PHENYL)-

N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-4-(5-FLUORO-2-METHOXY-3-PYRIDINYL)-2-METHOXYPHENYL)-N-

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(5-CHLORO-6-METHYL-3-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(2-PYRIDINYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(6-(3-FLUOROPHENYL)-4-METHOXY-3-PYRIDINYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE, (P)-1-(6-(3-FLUOROPHENYL)-4-

METHOXY-3-PYRIDINYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE (602), and (M)-1-(6-(3-FLUOROPHENYL)-4-METHOXY-

3-PYRIDINYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE (603)

(P)-1-(4-(5-CHLORO-2-METHOXY-3-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-2-OXO-N-2-PYRIMIDINYL-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(2-(3-CHLORO-5-FLUOROPHENYL)-5-METHOXY-4-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE (618)

N-3-ISOXAZOLYL-1-(2-METHOXY-5-(TETRAHYDRO-2H-PYRAN-4-YL)PHENYL)-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-(PYRROLIDIN-3-YLOXY)PHENYL)-N-(ISOXAZOL-3-YL)-

2-OXO-1,2-DIHYDROQUINOLINE-6-SULFONAMIDE

(P)-1-(5-FLUORO-2-METHOXY-4-(2-PYRIDINYL)PHENYL)-N-3-ISOXAZOLYL-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-2-METHOXY-4-(5-(TRIFLUOROMETHYL)-2-

PYRIDINYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(5-CHLORO-6-CYCLOPROPYL-2-METHOXY-3-PYRIDINYL)-N-3-ISOXAZOLYL-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-CYCLOPENTYL-5-FLUORO-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(5-CHLORO-6-(1,5-DIFLUOROPHENYL)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE (665) & (M)-1-

(5-CHLORO-6-(3,5-DIFLUOROPHENYL)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE (666)

(P)-1-(5-FLUORO-2-METHOXY-4-(TETRAHYDRO-2H-PYRAN-4-YL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-2-METHOXY-3-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-2-METHOXY-4-(2-METHOXY-5-METHYL-3-

PYRIDINYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-2-METHOXY-4-(5-(TRIFLUOROMETHYL)-3

PYRIDINYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-4-(6-FLUORO-5-METHYL-3-PYRIDINYL)-2-METHOXYPHENYL)-

N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(3″-CHLORO-2-FLUORO-5,5′,5″-TRIMETHOXY-1,1′:3′,1″-TERPHENYL-4-YL)-N

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-2-METHOXY-4-(6-METHOXY-3-PYRIDINYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-4-(5-FLUORO-3-PYRIDINYL)-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-2-METHOXY-4-(2-METHYL-4-PYRIDINYL)PHENYL)-N-3

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-2-METHOXY-4-(2-METHYL-3-PYRIDINYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-2-METHOXY-4-(5-METHOXY-3-PYRIDINYL)PHENYL)-N-3

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-2-METHOXY-4-(2-METHOXY-4-PYRIDINYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-6-METHOXY-3-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-(3-CHLORO-2-METHOXY-4-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-(3-CHLORO-4-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-2-METHOXY-4-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-2-METHOXY-4-(6-(TRIFLUOROMETHYL)-3-

PYRIDINYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-2-METHOXY-4-(2-(TRIFLUOROMETHYL)-4-

PYRIDINYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-2-METHOXY-3-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-N-(5-FLUORO-2-PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-2-METHOXY-3-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-2-OXO-N-3-PYRIDAZINYL-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-2-METHOXY-3-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-N-1,3-OXAZOL-2-YL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-2-METHOXY-3-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-N-(6-METHYL-4-PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-2-METHOXY-3-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-N-(2-METHYL-4-PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-(2,3-DIHYDRO-1-BENZOFURAN-7-YL)-2-METHOXYPHENYL)-N-3

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-2-METHOXY-4-(6-(TRIFLUOROMETHYL)-2-

PYRIDINYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-2-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-(4-CHLORO-2-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-2-METHOXY-4-(6-METHOXY-2-PYRIDINYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-6-METHYL-2-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-

N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-2-METHOXY-4-(4-METHOXY-2-PYRIMIDINYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-(2,3-DIHYDRO-1-BENZOFURAN-6-YL)-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-2-METHOXY-3-PYRIDINYL)-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-6-METHOXY-3-PYRIDINYL)-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(CYCLOPROPYLMETHOXY)-2-METHOXY-3-PYRIDINYL)-N-3

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(CYCLOBUTYLOXY)-2-METHOXY-3-PYRIDINYL)-N-3

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-6-((1-METHYLCYCLOPROPYL)METHOXY)-3

PYRIDINYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(CYCLOPENTYLMETHOXY)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(CYCLOPENTYLOXY)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(4,5-DIMETHYL-3-

ISOXAZOLYL)-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-CYCLOPROPYL-2-METHOXY-3-PYRIDINYL)-N-3-ISOXAZOLYL-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-6-(2,2,3,3,3-PENTAFLUOROPROPOXY)-3-PYRIDINYL)-

N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-6-(2,2,2-TRIFLUOROETHOXY)-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(2-CHLORO-5-METHOXY-4-PYRIDINYL)-N-3-ISOXAZOLYL-2-OXO-1,2-

DIHYDRO-6-QUINOLINESULFONAMIDE

1-(2-(3-CHLORO-5-FLUOROPHENYL)-5-METHOXY-4-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

N-3-ISOXAZOLYL-1-(2-METHOXY-5-(TETRAHYDRO-2H-PYRAN-4-YL)PHENYL)-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-4-(TRIFLUOROMETHYL)PHENYL)-2-OXO-N-4-

PYRIMIDINYL-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-4-(TRIFLUOROMETHYL)PHENYL)-2-OXO-N-4-

PYRIMIDINYL-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-CHLORO-2-(1-METHYL-1,2,3,6-TETRAHYDRO-4-PYRIDINYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(2-METHYL-4-PYRIMIDINYL)-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(6-METHYL-4-PYRIMIDINYL)-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(2-METHOXY-4-PYRIMIDINYL)-

2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(6-(METHOXYMETHYL)-4-

PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(6-METHOXY-4-PYRIMIDINYL)-

2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(1-METHYL-2-OXO-1,2-

DIHYDRO-4-PYRIDINYL)-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(2-ETHYL-4-PYRIMIDINYL)-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(6-METHYL-2-PYRIDINYL)-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(4-METHYL-2-PYRIMIDINYL)-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(2,6-DIMETHYL-4-

PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(6-METHOXY-2-PYRIDINYL)-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(2-CYANO-4-PYRIDINYL)-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-METHOXYPHENY)-N-(4,6-DIMETHYL-2-PYRIDINYL)-

2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(2-(METHOXY-METHYL)-4-

PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(3-FLUOROPHENYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

N-3-ISOXAZOLYL-1-(2-METHOXY-4-(2-METHOXY-5-METHYL-3-

PYRIDINYL)PHENYL)-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-2-METHOXYPHENYL)-2-OXO-N-3-PYRIDAZINYL-1,2 DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(4-BROMO-2-((1R)-1-CYANOETHOXY)-5-FLUOROPHENYL)-N-3-ISOXAZOLYL-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE, 1-(4-BROMO-2-((1S)-1-

CYANOETHOXY)-5-FLUOROPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(4-BROMO-2-(CYANOMETTIOXY)-5-FLUOROPHENYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-((3R)-3-PYRROLIDINYLOXY)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE, 1-(4-BROMO-5-

FLUORO-2-((3S)-3-PYRROLIDINYLOXY)PHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-

DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(3,5-DIFLUOROPHENYL)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(3-CHLORO-5-FLUOROPHENYL)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-CYCLOPENTYL-5-FLUORO-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(2,2-DIMETHYLPROPYL)-5-FLUORO-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-CYCLOHEXYL-5-FLUORO-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(CYCLOBUTYMETHYL)-5-FLUORO-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(CYCLOHEXYLMETHYL)-5-FLUORO-2-METHOXYPHENYL)-N-3

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(3,5-DIFLUOROPHENYL)-2-METHOXY-3-PYRIDINYL)-2-OXO-N-2-

PYRIMIDINYL-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(3,5-DIFLUOROPHENYL)-2-METHOXY-3-PYRIDINYL)-2-OXO-N-2-

PYRIMIDINYL-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(CYCLOPENTYLMETHYL)-5-FLUORO-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-((1R,2R,4R)-BICYCLO[2.2.1]HEPT-2-YLMETHYL)-5-FLUORO-2-

METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE, 1-(4-((1R,2R,4S)-BICYCLO[2.2.1]HEPT-2-YLMETHYL)-

5-FLUORO-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE, 1-(4-((1R,2S,4R)-BICYCLO[2.2.1]HEPT-2-YLMETHYL)-

5-FLUORO-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE, 1-(4-((1R,2S,4S)-BICYCLO[2.2.1]HEPT-2-YLMETHYL)-

5-FLUORO-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE, 1-(4-((1S,2R,4R)-BICYCLO[2.2.1]HEPT-2-YLMETHYL)-

5-FLUORO-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE, 1-(4-((1S,2R,4S)-BICYCLO[2.2.1]HEPT-2-YLMETHYL)-

5-FLUORO-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE, 1-(4-((1S,2S,4R)-BICYCLO[2.2.1]HEPT-2-YLMETHYL)-

5-FLUORO-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE, 1-(4-((1S,2S,4S)-BICYCLO[2.2.1]-HEPT-2-YLMETHYL)-

5-FLUORO-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(CIS-4-METHYLCYCLOHEXYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE, 1-(5-FLUORO-2-

METHOXY-4-(TRANS-4-METHYLCYCLOHEXYL)PHENYL)-N-3-ISOXAZOLYL-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(4-CHLORO-3-METHYLPHENYL)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(4-CHLORO-3-METHYLPHENYL)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(TETRAHYDRO-2H-PYRAN-4-YL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(CIS-4-METHOXYCYCLOHEXYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE, 1-(5-FLUORO-2-

METHOXY-4-(TRANS-4-METHOXYCYCLOHEXYL)PHENYL)-N-3-ISOXAZOLYL-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-((1R,2R,4S)-7-OXABICYCLO[2.2.1]HEPT-2-

YLMETHYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE, 1-(5-FLUORO-2-METHOXY-4-((1S,2S,4R)-7-

OXABICYCLO[2.2.1]HEPT-2-YLMETHYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-

DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-6-(3-METHYLPHENYL)-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-6-(3-METHYLPHENYL)-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(3-CYANOPHENYL)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(3-CYANOPHENYL)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-6-(3-METHOXYPHENYL)-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-6-(3-METHOXYPHENYL)-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDO-6-QUINOLINESULFONAMIDE

1-(4-(4,4-DIFLUOROCYCLOHEXYL)-5-FLUORO-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(2,3-DIHYDRO-1-BENZOFURAN-7-YL)-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(6-(TRIFLUOROMETHYL)-2-PYRIDINYL)PHENYL)-N-

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4″-CHLORO-2-FLUORO-5-METHOXY-1,1′:4′,1″-TERPHENYL-4-YL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(2-PYRIDINYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(5-CHLORO-2-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(4-CHLORO-2-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(6-METHOXY-2-PYRIDINYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(5-(TRIFLUOROMETHYL)-2-PYRIDINYL)PHENYL)-N-

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(5-CHLORO-6-METHYL-2-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(4-METHOXY-2-PYRIMIDINYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDO-6-QUINOLINESULFONAMIDE

1-(4-(2,3-DIHYDRO-1-BENZOFURAN-6-YL)-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(5-CHLORO-2-METHOXY-3-PYRIDINYL)-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(5-CHLORO-6-METHOXY-3-PYRIDINYL)-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(CYCLOPROPYLMETHOXY)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(CYCLOBUTYLOXY)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-6-((1-METHYLCYCLOPROPYL)METHOXY)-3-

PYRIDINYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(CYCLOPENTYLMETHOXY)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(CYCLOPENTYLOXY)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(4,5-DIMETHYL-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-CYCLOPROPYL-2-METHOXY-3-PYRIDINYL)-N-3-ISOXAZOLYL-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-2-MEITHOXY-6-(3-METHOXYPROPOXY)-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-6-(2,2,3,3,3-PENTAFLUOROPROPOXY)-3-PYRIDINYL)-

N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-6-(2,2,2-TRIFLUOROETHOXY)-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(CYCLOHEXYLMETHYL)-5-FLUORO-2-METHOXYPHENYL)-2-OXO-N-2-

PYRIMIDINYL-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(CYCLOHEXYLMETHYL)-5-FLUORO-2-METHOXYPHENYL)-N-1,3-OXAZOL-2-

YL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(CYCLOHEXYLMETHYL)-5-FLUORO-2-METHOXYPHENYL)-N-(5-FLUORO-2-

PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(CYCLOHEXYLMETHYL)-5-FLUORO-2-METHOXYPHENYL)-2-OXO-N-3-

PYRIDAZINYL-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(CYCLOHEXYLMETHYL)-5-FLUORO-2-METHOXYPHENYL)-N-1,2,4-

OXADIAZOL-3-YL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(CYCLOHEXYLMETHYL)-5-FLUORO-2-METHOXYPHENYL)-2-OXO-N-4-

PYRIMIDINYL-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(CYCLOHEXYLMETHYL)-5-FLUORO-2-METHOXYPHENYL)-2-OXO-N-2-

PYRAZINYL-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-((3R)-TETRAHYDRO-2H-PYRAN-3-

YLMETHYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE, 1-(5-FLUORO-2-METHOXY-4-((3S)-TETRAHYDRO-2H-

PYRAN-3-YLMETHYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(TETRAHYDRO-2H-PYRAN-4-YLMETHYL)PHENYL)-

N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(3,3-DIMETHYL-1-BUTYN-1-YL)-5-FLUORO-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-((3R)-TETRAHYDRO-3-FURANYLMETHYL)PHENYL)-

N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE, 1-(5-

FLUORO-2-METHOXY-4-((3S)-TETRAHYDRO-3-FURANYLMETHYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(3,3,3-TRIFLUORO-1-PROPYN-1-YL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-((2R)-TETRAHYDRO-2H-PYRAN-2-

YLMETHYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE, 1-(5-FLUORO-2-METHOXY-4-((2S)-TETRAHYDRO-2H-

PYRAN-2-YLMETHYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(CYCLOPENTYLAMINO)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(2-PYRIDINYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(2-METHOXY-5-METHYL-3-PYRIDINYL)PHENYL)-N-

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(5-(TRIFLUOROMETHYL)-3-PYRIDINYL)PHENYL)-N-

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-4-(6-FLUORO-5-METHYL-3-PYRIDINYL)-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(3″-CHLORO-2-FLUORO-5,5′,5″-TRIMETHOXY-1,1′:3′,1″-TERPHENYL-4-YL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(6-METHOXY-3-PYRIDINYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-4-(5-FLUORO-3-PYRIDINYL)-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(5-CHLORO-2-METHOXY-3-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(2-METHYL-4-PYRIDINYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(2-METHYL-3-PYRIDINYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(5-METHOXY-3-PYRIDINYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(2-METHOXY-4-PYRIDINYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(5-CHLORO-6-METHOXY-3-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(3-CHLORO-2-METHOXY-4-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(4-METHYL-2-OXO-1(2H)-PYRIDINYL)PHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(3-CHLORO-4-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(5-CHLORO-2-METHOXY-4-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(6-(TRIFLUOROMETHYL)-3-PYRIDINYL)PHENYL)-N-

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-FLUORO-2-METHOXY-4-(2-(TRIFLUOROMETHYL)-4-PYRIDINYL)PHENYL)-N-

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(6-(3-FLUOROPHENYL)-4-METHOXY-3-PYRIDINYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(6-(3-FLUOROPHENYL)-4-METHOXY-3-PYRIDINYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(6-(3-FLUOROPHENYL)-4-METHOXY-3-PYRIDINYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(5-CHLORO-2-METHOXY-3-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-2-

OXO-N-2-PYRIMIDINYL-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(5-CHLORO-2-METHOXY-3-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-

(5-FLUORO-2-PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(5-CHLORO-2-METHOXY-3-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-2-

OXO-N-3-PYRIDAZINYL-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(5-CHLORO-2-METHOXY-3-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-

1,3-OXAZOL-2-YL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(5-CHLORO-2-METHOXY-3-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-

(6-METHYL-4-PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(4-(5-CHLORO-2-METHOXY-3-PYRIDINYL)-5-FLUORO-2-METHOXYPHENYL)-N-

(2-METHYL-4-PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-((1R,3R)-3-(3-FLUOROPHENYL)CYCLOPENTYL)-N-3-ISOXAZOLYL-2-OXO-1,2-

DIHYDRO-6-QUINOLINESULFONAMIDE, 1-((1R,3S)-3-(3-

FLUOROPHENYL)CYCLOPENTYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE, 1-((1S,3R)-3-(3-FLUOROPHENYL)CYCLOPENTYL)-N-

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE, 1-((1S,3S)-3-

(3-FLUOROPHENYL)CYCLOPENTYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(5-CHLORO-4-CYCLOPROPYL-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(±)-1-((1S,2S)-2-METHOXYCYCLOHEXYL)-2-OXO-N-1,2,4-THIADIAZOL-5-YL-1,2-

DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-6-METHOXY-3-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-2-OXO-N-2-PYRIMIDINYL-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-6-METHOXY-3-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-N-(5-FLUORO-2-PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-6-METHOXY-3-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-2-OXO-N-3-PYRIDAZINYL-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-6-METHOXY-3-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-N-1,3-OXAZOL-2-YL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-6-METHOXY-3-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-N-(6-METHYL-4-PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-6-METHOXY-3-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-N-(2-METHYL-4-PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-6-METHOXY-3-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-N-(5-FLUORO-2-PYRIDINYL)-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-(5-CHLORO-6-METHOXY-3-PYRIDINYL)-5-FLUORO-2-

METHOXYPHENYL)-N-(6-FLUORO-2-PYRIDINYL)-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(2-(5-CHLORO-2-FLUOROPHENYL)-5-METHOXY-4-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(2-(4-CHLORO-2-FLUOROPHENYL)-5-METHOXY-4-PYRIDINIYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

N-3-ISOXAZOLYL-1-(2-METHOXYPHENYL)-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(2,6-DIFLUOROPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(2-FLUOROPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(2-ETHYLPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(6-

(CYCLOPROPYLMETHOXY)-4-PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(6-

(CYCLOBUTYLMETHOXY)-4-PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(6-

(CYCLOPENTYLMETHOXY)-4-PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-2-OXO-N-(6-PROPOXY-4-

PYRIMIDINYL)-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(6-(2-METHYLPROPOXY)-4-

PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(6-(CYCLOBUTYLOXY)-4-

PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(6-((1-

METHYLCYCLOPROPYL)METHOXY)-4-PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(6-(CYCLOPENTYLOXY)-4-

PYRIMIDINYL)-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(1-METHYL-1H-PYRAZOL-3-

YL)-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-BROMO-5-FLUORO-2-METHOXYPHENYL)-N-(1-ETHYL-1H-PYRAZOL-3-

YL)-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-(4-FLUOROPHENOXY)-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(M)-1-(4-(4-FLUOROPHENOXY)-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-

1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(5-CHLORO-6-(4-FLUOROPHENYL)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(M)-1-(5-CHLORO-6-(4-FLUOROPHENYL)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-((1R,3R)-3-(3-FLUOROPHENYL)CYCLOPENTYL)-N-3-ISOXAZOLYL-2-OXO-1,2-

DIHYDRO-6-QUINOLINESULFONAMIDE, 1-((1R,3S)-3-(3-

FLUOROPHENYL)CYCLOPENTYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE 1-((1S,3R)-3-(3-FLUOROPHENYL)CYCLOPENTYL)-N-

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE, 1-(1S,3S)-3-

(3-FLUOROPHENYL)CYCLOPENTYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(5-CHLORO-4-CYCLOPROPYL-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-CYCLOPROPYL-5-FLUORO-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(4-CYCLOPROPYL-2-METHOXYPHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-

DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(2,2-DIFLUORO-2-(TETRAHYDRO-2H-PYRAN-4-YL)ETHOXY)-2-

METHOXY-3-PYRIDINYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-6-(((1R)-2,2,3,3-TETRAFLUORO-1-

METHYLPROPYL)OXY)-3-PYRIDINYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE, 1-(5-CHLORO-2-METHOXY-6-(((1S)-2,2,3,3-

TETRAFLUORO-1-METHYLPROPYL)OXY)-3-PYRIDINYL)-N-3-ISOXAZOLYL-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-((2,4-DIFLUOROBENZYL)OXY)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-((4-FLUOROBENZYL)OXY)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-((4-FLUORO-3-(TRIFLUOROMETHYL)BENZYL)OXY)-2-METHOXY-

3-PYRIDINYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-6-((2,3,4-TRIFLUOROBENZYL)OXY-3-PYRIDINYL)-N-

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-((3,4-DIFLUOROBENZYL)OXY)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-6-((3,4,5-TRIFLUOROBENZYL)OXY)-3-PYRIDINYL)-N-

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(CYCYLOHEXYLMETHOXY)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(4-FLUOROPHENOXY)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(4-FLUOROPHENOXY)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(4-FLUOROPHENOXY)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(6-((1R,2S,4S)-BICYCLO[2.2.1]HEPT-2-YLOXY)-5-CHLORO-2-METHOXY-3-

PYRIDINYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-6-(((1S,2R)-2-METHYLCYCLOHEXYL)OXY)-3-

PYRIDINYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(2,5-DIFLUOROPHENOXY)-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(3-CHLORO-2-METHYLPHENOXY)-2-METHOXY-3-PYRIDINYL)-N-

3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-((1S,2S)-2-METHOXYCYCLOHEXYL)-2-OXO-N-1,2,4-THIADIAZOL-5-YL-1,2-

DIHYDRO-6-QUINOLINESULFONAMIDE

1-((1S,2S)-2-METHOXYCYCLOPENTYL)-2-OXO-N-1,2,4-THIADIAZOL-5-YL-1,2-

DIHYDRO-6-QUINOLINESULFONAMIDE

(M)-1-(5-CHLORO-6-CYCLOPROPYL-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

(P)-1-(5-CHLORO-6-CYCLOPROPYL-2-METHOXY-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-(CYCLOPENTYL(METHYL)AMINO)-2-METHOXY-3-PYRIDINYL)-

N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE

1-(5-CHLORO-6-((((2R)-5,5-DIMETHYLTETRAHYDRO-2-

FURANYL)METHYL)AMINO)-2-METHOXY-3-PYRIDINYL)-N-3-ISOXAZOLYL-2-

OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE, 1-(5-CHLORO-6-((((2S)-5,5-

DIMETHYLTETRAHYDRO-2-FURANYL)METHYL)AMINO)-2-METHOXY-3-

PYRIDINYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-2-METHOXY-4-((3S)-TETRAHYDRO-3-

FURANYLMETHYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

(P)-1-(5-FLUORO-2-METHOXY-4-((3R)-TETRAHYDRO-3-

FURANYLMETHYL)PHENYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-6-(((METHYLCYCLOPENTYL)METHYL)AMINO)-3-

PYRIDINYL)-N-3-ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-

QUINOLINESULFONAMIDE

1-(5-CHLORO-2-METHOXY-6-((((2R)-2-METHYLTETRAHYDRO-2-

FURANYL)METHYL)AMINO)-3-PYRIDINYL-N-3-ISOXAZOLYL-2-OXO-1,2-

DIHYDRO-6-QUINOLINESULFONAMIDE, 1-(5-CHLORO-2-METHOXY-6-((2S)-2-

METHYLTETRAHYDRO-2-FURANYL)METHYL)AMINO)-3-PYRIDINYL)-N-3-

ISOXAZOLYL-2-OXO-1,2-DIHYDRO-6-QUINOLINESULFONAMIDE.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 16, 2016
From: WEISS, MATTHEW; BOEZIO, ALESSANDRO; BOEZIO, CHRISTIANE; BUTLER, JOHN R.; CHU-MOYER, MARGARET YUHUA; DIMAURO, ERIN F.; DINEEN, THOMAS; GRACEFFA, RUSSELL; GUZMAN-PEREZ, ANGEL; HUANG, HONGBING; KREIMAN, CHARLES; LA, DANIEL; MARX, ISAAC E.; MILGRAM, BENJAMIN CHARLES; NGUYEN, HANH NHO; PETERSON, EMILY; ROMERO, KARINA; SPARLING, BRIAN
To: AMGEN INC.
Reel/Frame 037837/0001 →
Continuity (4)
Continuation 14302337 · Jun 11, 2014
Provisional Application 61983958 · Apr 24, 2014
Provisional Application 61834273 · Jun 12, 2013
Related Publication 20160046626A1 · Feb 18, 2016