IP Library › Granted Patent US 9,468,660
Granted Patent B2
US 9,468,660 · App. 13/982,996 · Granted Oct 18, 2016

Antinematodal methods and compositions

Inventors: Benjamin Podbilewicz (Haifa, IL); Ori Avinoam (Haifa, IL); Judith M. White (Charlottesville, VA)
Assignees: Technion Research and Development Foundation Ltd.; University of Virginia Patent Foundation
A61K36/00A01N63/00A61K35/12A61K35/57A61K35/76C07K14/4354C07K14/43545
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 9,468,660
App. No.
13/982,996
Granted
Oct 18, 2016
Kind
B2
Abstract

There are provided methods and compositions useful in cell-cell fusion using Fusion Family (FF) proteins of nematode origin. There are further provided antinematodal methods and compositions, utilizing fusogenic proteins of the nematode Fusion Family.

Claims (4)

1. A method for fusing a first mammalian cell and a second mammalian cell; comprising:

(i) incubating a first mammalian cell expressing a nematode fusogenic protein with a second mammalian cell expressing a nematode fusogenic protein; and

(ii) fusing the first and second mammalian cells, wherein the nematode fusogenic protein is selected from the group consisting of anchor-cell fusion failure 1 (AFF-1) and epithelial fusion failure 1 (EFF-1) and wherein the first and second mammalian cells are of the same species.

2. The method of claim 1 , wherein expression of the nematode fusogenic protein is transient or stable.

Assignments (4)
CONFIRMATORY LICENSE Recorded Nov 5, 2013
From: UNIVERSITY OF VIRGINIA PATENT FOUNDATION D.B.A. UNIVERSITY OF VIRGINIA LICENSING AND VENTURES GROUP
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031579/0847 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 3, 2013
From: PODBILEWICZ, BENJAMIN; AVINOAM, ORI
To: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
Reel/Frame 031127/0095 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 3, 2013
From: WHITE, JUDITH
To: UNIVERSITY OF VIRGINIA
Reel/Frame 031127/0198 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 3, 2013
From: UNIVERSITY OF VIRGINIA
To: UNIVERSITY OF VIRGINIA PATENT FOUNDATION, D/B/A UNIVERSITY OF VIRGINIA LICENSING & VENTURES GROUP
Reel/Frame 031127/0314 →
Continuity (2)
Provisional Application 61438274 · Feb 1, 2011
Related Publication 20130336939A1 · Dec 19, 2013