1,3-benzothiazinone sulfoxide and sulfone compounds

1. A compound, having the following formula:

or resonance form thereof, or salt thereof, or salt of resonance form thereof;

wherein R 1 -R 4 are each independently hydrogen, an alkyl group, a cycloalkyl group, a cycloalkenyl group, a halo group, an alkenyl group, an alkynyl group, an aryl group, a hydroxy group, an acyl group, an oxo group, a mercapto group, an alkylthio group, an alkoxy group, a heterocyclic group, a heteroaryl group, a heteroarylcarbonyl group, an aryloxy group, a heteroaryloxy group, an aralkyl group, a heteroaralkyl group, an aralkoxy group, a heteroaralkoxy group, an amino group, an alkylamino group, a dialkylamino group, an amidine group, an amide group, a carbamoyl group, an alkylcarbonyl group, an alkoxycarbonyl group, an alkylaminocarbonyl group, a dialkylamino carbonyl group, an arylcarbonyl group, an aryloxycarbonyl group, an alkylsulfonyl group, an arylsulfonyl group, perhaloalkyl group, a perhaloalkoxy group, a perhalocycloalkyl group, a perhaloalkenyl group, a perhaloalkynyl group, a perhaloaryl group, a perhaloaralkyl group, or combination thereof;

wherein R 3 and R 4 may be taken together with the nitrogen to which they are attached to form a cyclic group;

wherein each group may be optionally and independently straight or branched; wherein each group may be optionally and independently substituted by one or more independent substituents; and wherein one or more than one atom in each group may be optionally and independently replaced with one or more independent heteroatoms;

wherein the one or more independent substituents is one or more of an acyl group, alkenyl group, alkoxy group, alkoxycarbonyl group, alkoxycarbonyloxy group, alkoxysulfonyloxy group, alkyl group, alkylamino group, alkylaminocarbonyl group, alkylcarbonyl group, alkylcarbonyloxy group, alkylsulfonyl group, alkylsulfonyloxy group, alkylthio group, alkynyl group, amide group, amidine group, amino group, aralkoxy group, aralkyl group, aryl group, arylcarbonyl group, arylcarbonyloxy group, aryloxy group, aryloxycarbonyl group, aryloxycarbonyloxy group, aryloxysulfonyloxy group, arylsulfonyl group, arylsulfonyloxy group, azido group, carbamido group, carbamoyl group, carbazoyl group, carbonyl group, carboxylate group, carboxylic acid group, cyanato group, cyano group, cycloalkenyl group, cycloalkyl group, dialkylamino carbonyl group, dialkylamino group, guanidino group, guanyl group, halo group, heteroaralkoxy group, heteroaralkyl group, heteroaryl group, heteroarylcarbonyl group, heteroaryloxy group, heterocyclic group, hydroxamino group, hydroxy group, imino group, isocyanato group, isocyano group, mercapto group, nitro group, oxo group, perhaloalkenyl group, perhaloalkoxy group, perhaloalkyl group, perhaloalkynyl group, perhaloaralkyl group, perhaloaryl group, perhalocycloalkyl group, phosphate group, phosphine group, phospho group, sulfate group, sulfo group, sulfonyl group, oxidized form thereof, or combination thereof;

and wherein n is 1 or 2.

2. The compound of claim 1 ,

wherein R 1 -R 4 are each independently hydrogen, alkyl, allyl, cycloalkyl, aryl, acyl, aroyl, or combination thereof,

said alkyl and allyl being independently linear, branched, substituted, unsubstituted, or combination thereof,

said cycloalkyl being substituted or unsubstituted, the alkyl portion of which being linear, branched, substituted, unsubstituted, or combination thereof,

said aryl, acyl, and aroyl being independently substituted or unsubstituted;

wherein R 3 and R 4 taken together with the nitrogen to which they are attached may optionally form a cyclic group, said cyclic group being substituted, unsubstituted, saturated, unsaturated, or combination thereof;

and wherein n is 1 or 2.

3. The compound of claim 1 , wherein one or more than one atom in one or more of R 1 -R 4 is independently replaced with one or more independent heteroatom.

4. The compound of claim 1 , wherein one or more than one carbon in one or more of R 1 -R 4 is independently replaced with one or more independent heteroatom selected from the group consisting of N, O, S, or combination thereof.

5. The compound of claim 1 , wherein R 1 -R 4 are independently hydrogen, alkyl, substituted alkyl, linear alkyl, branched alkyl, allyl, substituted allyl, heteroalkyl, cycloalkyl, aryl, substituted aryl, heteroaryl, acyl, aroyl, heteroaroyl, or combination thereof.

6. The compound of claim 1 , wherein R 3 and R 4 taken together with the nitrogen to which they are attached form a C 3 -C 10 cyclic group, said cyclic group being substituted, unsubstituted, saturated, unsaturated, or combination thereof.

7. The compound of claim 1 , wherein R 3 and R 4 taken together with the nitrogen to which they are attached form a cyclic group, and wherein one or more than one carbon in the cyclic group is independently and optionally replaced with one or more heteroatom.

8. The compound of claim 1 wherein R 3 and R 4 taken together with the nitrogen to which they are attached form a C 3 -C 6 cyclic group.

9. The compound of claim 1 , wherein R 3 and R 4 taken together with the nitrogen to which they are attached form a cycloalkene, heterocycle, mixed carbocycle and heterocycle, oxidized form thereof, or combination thereof.

10. The compound of claim 1 , having one of the following formulas:

wherein R 5 is hydrogen, an alkyl group, a cycloalkyl group, a cycloalkenyl group, a halo group, an alkenyl group, an alkynyl group, an aryl group, a hydroxy group, an acyl group, an oxo group, a mercapto group, an alkylthio group, an alkoxy group, a heterocyclic group, a heteroaryl group, a heteroarylcarbonyl group, an aryloxy group, a heteroaryloxy group, an aralkyl group, a heteroaralkyl group, an aralkoxy group, a heteroaralkoxy group, an amino group, an alkylamino group, a dialkylamino group, an amidine group, an amide group, a carbamoyl group, an alkylcarbonyl group, an alkoxycarbonyl group, an alkylaminocarbonyl group, a dialkylamino carbonyl group, an arylcarbonyl group, an aryloxycarbonyl group, an alkylsulfonyl group, an arylsulfonyl group, perhaloalkyl group, a perhaloalkoxy group, a perhalocycloalkyl group, a perhaloalkenyl group, a perhaloalkynyl group, a perhaloaryl group, a perhaloaralkyl group, or combination thereof; and

wherein each group may be optionally and independently straight or branched; wherein each group may be optionally and independently substituted by one or more independent substituents; and wherein one or more than one atom in each group may be optionally and independently replaced with one or more independent heteroatoms.

11. A composition, comprising the compound of claim 1 and a physiologically acceptable carrier.

12. A method, comprising administering the compound of claim 1 to a subject in need thereof, to treat said subject, wherein the subject is known or suspected to need treatment for one or more maladies related to non-pathogenic mycobacterial strain, M. smegmatis, M. vaccae, M. aurum , Gram positive bacteria, S. aureus, M. luteus , Gram negative bacteria, P. aeruginosa, A. baumanii , pathogenic mycobacterial strain, M. tuberculosis, M. bovis, M. marinum, M. kansasaii , H37Rv, M. africanum, M. canetti, M. caprae, M. microti, M. mungi, M. pinnipedii , myobacterium tuberculosis complex, tuberculosis, or combination thereof.

13. A method, comprising administering the composition of claim 11 to a subject in need thereof, to treat said subject, wherein the subject is known or suspected to need treatment for one or more maladies related to non-pathogenic mycobacterial strain, M. smegmatis, M. vaccae, M. aurum , Gram positive bacteria, S. aureus, M. luteus , Gram negative bacteria, P. aeruginosa, A. baumanii , pathogenic mycobacterial strain, M. tuberculosis, M. bovis, M. marinum, M. kansasaii , H37Rv, M. africanum, M. canetti, M. caprae, M. microti, M. mungi, M. pinnipedii , myobacterium tuberculosis complex, tuberculosis, or combination thereof.