T-cell death-inducing epitopes
Cell death-inducing epitopes and polypeptides containing same. Also disclosed are compounds for inducing death of activated T-cells, a method of producing antibodies to the epitopes, a method of identifying compounds that bind to the epitopes, a method of inducing death of activated T-cells, and pharmaceutical compositions containing the compounds.
1. An isolated polypeptide comprising SEQ ID NO: 20 or SEQ ID NO: 22, wherein binding of a ligand to the polypeptide on activated T-cells induces death of the cells.
2. An isolated polypeptide comprising SEQ ID NO: 21, wherein binding of a ligand to the polypeptide on activated T-cells induces death of the cells.
3. The polypeptide of claim 2 , wherein the polypeptide is 12 to 1500 amino acids in length.
4. The polypeptide of claim 3 , wherein the polypeptide is 12 to 150 amino acids in length.
5. The polypeptide of claim 4 , wherein the polypeptide is 12 to 15 amino acids in length.
6. The polypeptide claim 2 , wherein the polypeptide is SEQ ID NO: 21.
7. A pharmaceutical composition comprising the polypeptide of claim 2 .
8. A pharmaceutical composition comprising the polypeptide of claim 1 .