Pyrrolo[3,2-]pyrimidine derivatives for the treatment of viral infections and other diseases
This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
1. A compound of formula (I)
a pharmaceutically acceptable salt or solvate thereof wherein;
R 1 is H, fluorine or methyl;
R 2 is H, halogen or C 1-3 alkyl;
R 3 is C 1-6 alkyl optionally substituted by aryl wherein said aryl is optionally-substituted by one or more substituents independently selected from the group consisting of aryloxy, halogen, aryl, alkylamino, dialkylamino, C 1-6 alkyl, —CO 2 H, —C(O)OC 1-6 alkyl, —CONH 2 , —CN, and C 1-6 alkoxy; or
R 3 is C 1-6 alkyl optionally substituted by C 1-6 alkene, C 3-7 cycloalkyl or C 3-7 heterocycloalkyl; or
R 3 is C 1-6 alkyl optionally substituted by C 1-6 alkoxy wherein said C 1-6 alkoxy is optionally substituted by aryl; and
R 4 is C 1-8 alkyl optionally substituted by one or more substituents independently selected from the group consisting of hydroxyl, C 1-6 alkoxy, C 1-6 alkyl, C 3-7 cycloalkyl, C 2-6 alkenyl, aryl, heteroaryl, and C 3-7 cycloalkyl wherein said heteroaryl and said C 3-7 cycloalkyl are optionally substituted by C 1-6 alkyl;
with the proviso that 2-amino, 4-(N-butylamino)-5-(alphamethylbenzyl)pyrrolo[3,2-d] pyrimidine is excluded.
2. A compound as claimed in claim 1 , wherein R 3 is methyl optionally substituted by aryl.
3. A compound as claimed in claim 1 , wherein each of R 3 and R 4 is independently C 1-3 alkyl substituted by aryl.
4. A compound as claimed in claim 1 , wherein R 1 is fluorine and R 2 is hydrogen.
5. A pharmaceutical composition comprising a compound as claimed in claim 1 together with one or more pharmaceutically acceptable excipients, diluents or carriers.
6. A compound as claimed in claim 1 , wherein R 3 is aryl-substituted C 1-3 alkyl and the aryl in said aryl-substituted C 1-3 alkyl is optionally substituted by one or more substituents independently selected from the group consisting of aryloxy, halogen, aryl, alkylamino, dialkylamino, C 1-6 alkyl, —CO 2 H, C(O)OC 1-6 alkyl, —CONH 2 , —CN, and C 1-6 alkoxy; and R 4 is aryl-substituted C 1-3 alkyl.