Pharmaceutical formulations for treating ocular conditions

1. A pharmaceutical formulation for local administration into the nasal cavity of an individual comprising a non-systemically bio available dose between 5 micrograms and 50 micrograms of varenicline per dose formulated (a) for nasal administration and (b) to prevent desensitization.

2. The pharmaceutical formulation of claim 1 , wherein varenicline is formulated in a dosage amount that does not result in undesired psychoactive side effects.

3. The pharmaceutical formulation of claim 1 , wherein varenicline is formulated in a dosage amount that does not result in undesired systemic side effects.

4. The pharmaceutical formulation of claim 1 , further comprising one or more substances selected from protein kinase C (PKC) or factors that upregulate or up-modulate PKC, cAMP-dependent protein kinase (PKA) or factors that upregulate or up-modulate PKA, and calcineurin inhibitors.

5. The pharmaceutical formulation of claim 4 , wherein the calcineurin inhibitor is selected from cyclosporine, pimecrolimus, and tacrolimus.

6. The pharmaceutical formulation of claim 1 , wherein varenicline selectively binds to at least one of the peripheral nicotinic acetylcholine receptor subtypes selected from alpha3beta4, alpha4beta2, and alpha7.

7. The pharmaceutical formulation of claim 1 , wherein the pharmaceutical formulation comprises about 1 mg/mL of varenicline.

8. The pharmaceutical formulation of claim 1 , wherein the pharmaceutical formulation comprises about 0.5 mg/mL of varenicline.

9. The pharmaceutical formulation of claim 1 , wherein the formulation is administered at least once daily.

10. The pharmaceutical formulation of claim 1 , wherein the formulation is administered at least twice daily.

11. The pharmaceutical formulation of claim 1 , wherein the formulation is administered at least once weekly.

12. The pharmaceutical formulation of claim 1 , wherein the formulation is administered into the nasal cavity as a liquid, suspension, aerosol, gel, ointment, dry powder, cream, paste, lotion, or balm.

13. The pharmaceutical formulation of claim 1 , wherein the formulation is administered into the nasal cavity by a syringe, dropper, bottle nebulizer, atomization pump, inhaler, powder spray device, vaporizer, patch, medicated stick, pipette, or jet of liquid.