Biodegradable metal alloys
The invention relates to biodegradable, metal alloy-containing compositions, methods for their preparation and applications for their use. The compositions include magnesium and other components, such as yttrium, calcium, silver, cerium, and zirconium; or zinc, silver, cerium, and zirconium; or aluminum, zinc, calcium, manganese, silver, yttrium; or strontium, calcium, zinc. The compositions are prepared by vacuum induction/crucible melting together the components and casting the melted mixture in a preheated mild steel/copper mold. In certain embodiments, the compositions of the invention are particularly useful for forming medical devices for implantation into a body of a patient.
1. A metal alloy-containing composition, consisting of:
from about 0.5 weight percent to about 4.0 weight percent of yttrium;
from greater than zero to about 1.0 weight percent of calcium;
from about 0.25 weight percent to about 1.0 weight percent of zirconium;
from about 1.0 weight percent to about 4.0 weight percent of strontium;
optionally from about 1.0 weight percent to about 9.0 weight percent of aluminum;
optionally from about 0.1 weight percent to about 1.0 weight percent of manganese;
optionally from about 0.25 weight percent to about 1.0 weight percent of silver;
optionally from about 0.1 weight percent to about 1.0 weight percent of cerium;
and a balance of magnesium and impurities due to production, based on the total weight of the composition,
wherein the metal alloy-containing composition is used to form a biodegradable, medical implant device.
2. The composition of claim 1 , wherein the silver is present in an amount of from about 0.25 weight percent to about 1.0 weight percent based on the total weight of the composition.
3. The composition of claim 1 , wherein the cerium is present in an amount of from about 0.1 weight percent to about 1.0 weight percent based on the total weight of the composition.
4. The composition of claim 1 , wherein the aluminum is present in an amount from about 1.0 weight percent to about 9.0 weight percent based on the total weight of the composition.
5. A metal alloy-containing composition, consisting of:
from about 1.0 weight percent to about 6.0 weight percent of zinc;
from greater than zero to about 1.0 weight percent of zirconium;
from about 1.0 weight percent to about 4.0 weight percent of strontium;
optionally from about 1.0 weight percent to about 9.0 weight percent of aluminum;
optionally from about 0.1 weight percent to about 1.0 weight percent of manganese;
optionally from about 0.25 weight percent to about 1.0 weight percent of silver;
optionally from about 0.1 weight percent to about 1.0 weight percent of cerium; and
a balance of magnesium and impurities due to production, based on the total weight of the composition,
wherein the metal alloy-containing composition is used to form a biodegradable, medical implant device.
6. The composition of claim 5 , wherein the silver is present in an amount of from about 0.25 weight percent to about 1.0 weight percent based on the total weight of the composition.
7. The composition of claim 5 , wherein the cerium is present in an amount of from about 0.1 weight percent to about 1.0 weight percent based on the total weight of the composition.
8. A method of preparing a biodegradable, medical implant device, the method comprising:
melting a metal alloy-containing composition to form a melted magnesium alloy mixture, the metal alloy-containing composition is selected from the group consisting of
(1) from about 1.0 weight percent to about 4.0 weight percent of strontium, from about 0.5 weight percent to about 4.0 weight percent of yttrium, from greater than zero to about 1.0 weight percent of calcium, from about 0.25 weight percent to about 1.0 weight percent of zirconium, optionally from about 1.0 weight percent to about 9.0 weight percent of aluminum, optionally from about 0.1 weight percent to about 1.0 weight percent of manganese, optionally from about 0.25 weight percent to about 1.0 weight percent of silver, optionally from about 0.1 weight percent to about 1.0 weight percent of cerium, and with a balance of magnesium and impurities due to production, based on the total weight of the composition, and
(2) from about 1.0 weight percent to about 4.0 weight percent of strontium, from about 1.0 weight percent to about 6.0 weight percent of zinc, from greater than zero to about 1.0 weight percent of zirconium, optionally from about 1.0 weight percent to about 9.0 weight percent of aluminum, optionally from about 0.1 weight percent to about 1.0 weight percent of manganese, optionally from about 0.25 weight percent to about 1.0 weight percent of silver, optionally from about 0.1 weight percent to about 1.0 weight percent of cerium, and with a balance of magnesium and impurities due to production, based on the total weight of the composition; and
casting said melted magnesium alloy mixture to obtain said biodegradable, medical implant device.
9. The method of claim 8 wherein the metal alloy-containing composition consists of:
from about 1.0 weight percent to about 4.0 weight percent of strontium;
from about 1.0 weight percent to about 6.0 weight percent of zinc;
from greater than zero to about 1.0 weight percent of zirconium, and
the balance is magnesium, based on the total weight of the composition.
10. The method of claim 8 , wherein the silver is present from about 0.25 weight percent to about 1.0 weight percent and the cerium is present from about 0.1 weight percent to about 1.0 weight percent based on the total weight of the composition.
11. The method of claim 8 , wherein the manganese is present in an amount from about 0.1 weight percent to about 1.0 weight percent based on the total weight of the composition.
12. A biodegradable, medical implant device containing the metal alloy-containing composition of claim 1 , wherein the device is selected from the group consisting of an orthopedic device, a craniofacial device and a cardiovascular device.
13. The biodegradable, medical implant device of claim 12 , further comprising at least one active substance selected from the group consisting of bone growth promoting agents, drugs, proteins, antibiotics, antibodies, ligands, DNA, RNA, peptides, enzymes, vitamins, cells and combinations thereof.
14. A biodegradable, metal alloy-containing composition, consisting of:
from greater than zero to about 1.0 weight percent of calcium;
from about 0.5 weight percent to about 4.0 weight percent of yttrium;
from about 0.25 weight percent to about 1.0 weight percent of zirconium;
optionally from about 1.0 weight percent to about 4.0 weight percent of strontium;
optionally from about 1.0 weight percent to about 9.0 weight percent of aluminum;
optionally from about 0.1 weight percent to about 1.0 weight percent of manganese;
optionally from about 0.25 weight percent to about 1.0 weight percent of silver;
optionally from about 0.1 weight percent to about 1.0 weight percent of cerium; and
a balance of magnesium and impurities due to production, based on the total weight of the composition.