Tricyclic triazolic compounds

1. A compound of formula (I)

wherein

R 1 is selected from:

a —(C(R 3 ) 2 ) m -aryl group in which the aryl group may be optionally substituted by at least one halogen atom;

a —(C(R 3 ) 2 ) m -heteroaryl group in which the heteroaryl group may be optionally substituted by at least one substituent selected from a halogen, C 1-3 -alkyl, C 1-3 -alkoxy, C 1-3 -haloalcoxy or C 1-3 -haloalkyl and in which the heteroaryl group may optionally be condensed with an additional ring system;

a —(C(R 3 ) 2 ) n -heterocycloalkyl group, in which the heterocycloalkyl may be optionally substituted by at least one substituent selected from a halogen, C 1-3 -alkyl, C 1-3 -alkoxy, C 1-3 -haloalcoxy or C 1-3 -haloalkyl and contains at least one oxygen atom;

R 2 is selected from:

a phenyl group optionally substituted by at least one substitutent selected from a halogen, C 1-3 -alkoxy, C 1-3 -haloalcoxy, C 1-3 -haloalkyl or a hydroxyl group;

a heteroaryl group optionally substituted by at least one substitutent selected from a halogen, C 1-3 -alkyl C 1-3 -alkoxy, C 1-3 haloalcoxy, C 1-3 -haloalkyl or a hydroxyl group;

a heterocycloalkyl group and being optionally substituted by at least one substituent selected from a halogen, C 1-3 -alkyl, C 1-3 -alkoxy, C 1-3 -haloalcoxy, C 1-3 -haloalkyl or a hydroxyl group;

R 3 is H or C 1-3 alkyl;

m is 1 to 3; and

n is 0 to 3;

with the proviso that when R 1 is a —(C(R 3 ) 2 ) m -aryl group, R 2 is not a phenyl group;

or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof.

2. A compound according to claim 1 , wherein R 1 is a benzyl optionally substituted by at least one halogen; a —(C(R 3 ) 2 ) m -heteroaryl group in which the heteroaryl is a 5 or 6 membered heteroaryl radical containing from 1 to 3 heteroatoms selected from N or O and is optionally substituted by at least one substituent selected from a halogen, C 1-3 -alkyl, C 1-3 -alkoxy or C 1-3 -haloalkyl; or a —(C(R 3 ) 2 ) n -heterocycloalkyl group, in which the heterocycloalkyl group is a tetrahydropyranyl or as tetrahydrofuranyl group.

3. A compound according to claim 1 , wherein R 1 is selected from:

wherein R a represents a hydrogen, a halogen, C 1-3 alkyl, C 1-3 -alkoxy or C 1-3 haloalkyl, R b represents a hydrogen or a halogen and m and n are as defined in claim 1 .

4. A compound according to claim 1 , wherein R 2 is a phenyl optionally substituted by at least one substituent selected from a halogen or C 1-3 haloalkyl; a 5 or 6 membered heteroaryl radical containing from 1 to 3 N atoms and optionally substituted by at least one substituent selected from a halogen, C 1-3 -alkyl or C 1-3 -alkoxy; or a tetrahydropyranyl group.

5. A compound according to claim 1 , wherein R 2 is selected from:

wherein represents a hydrogen, halogen, C 1-3 alkyl, C 1-3 alkoxy, C 1-3 haloalkyl.

6. A compound according to claim 1 , wherein R 1 is selected from:

R 2 is selected from:

wherein R a represents a hydrogen, a halogen, C 1-3 alkyl, C 1-3 -alkoxy or C 1-3 haloalkyl, R b represents a hydrogen or a halogen, R c represents a hydrogen, halogen, C 1-3 alkyl, C 1-3 alkoxy, C 1-3 haloalkyl and m and n are as defined in claim 1 .

7. A compound according to claim 1 , selected from the group consisting of:

(5aR,8aR)-3-(2-fluorophenyl)-7-(pyridin-3-ylmethyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aRS,8aRS)-3-(2-fluorophenyl)-7-(pyridin-4-ylmethyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aRS,8aRS)-3-(2-fluorophenyl)-7-(pyridin-2-ylmethyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(4-fluorophenyl)-7-(tetrahydro-2H-pyran-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(4-fluorophenyl)-7-(tetrahydro-2H-pyran-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2-fluorophenyl)-7-(tetrahydro-2H-pyran-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2-fluorophenyl)-7-(tetrahydro-2H-pyran-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(6-methoxypyridin-3-yl)-7-(tetrahydro-2H-pyran-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2-fluorophenyl)-7-((tetrahydro-2H-pyran-4-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2-fluorophenyl)-7-((tetrahydro-2H-pyran-4-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2-fluorophenyl)-7-((6-fluoropyridin-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2-fluorophenyl)-7-((6-methoxypyridin-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2-fluorophenyl)-7-((6-methoxypyridin-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2-fluorophenyl)-7-((6-(trifluoromethyl)pyridin-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2-fluorophenyl)-7-(((R)-tetrahydrofuran-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2-fluorophenyl)-7-(((S)-tetrahydrofuran-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2-fluorophenyl)-7-(((S)-tetrahydrofuran-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2-fluorophenyl)-7-(((R)-tetrahydrofuran-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-7-((6-ethoxypyridin-3-yl)methyl)-3-(2-fluorophenyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-7-((6-ethoxypyridin-3-yl)methyl)-3-(2-fluorophenyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aRS,8aRS)-3-(4-fluorophenyl)-7-(furan-3-ylmethyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2,4-difluorophenyl)-7-((2,5-dimethylfuran-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2,4-difluorophenyl)-7-((2,5-dimethylfuran-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-7-(4-fluorobenzyl)-3-(pyridin-2-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-7-(4-fluorobenzyl)-3-(pyridin-2-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aRS,8aRS)-7-(4-fluorobenzyl)-3-(pyridin-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2,4-difluorophenyl)-7-(tetrahydro-2H-pyran-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2,4-difluorophenyl)-7-(tetrahydro-2H-pyran-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-7-(4-fluorobenzyl)-3-(3-fluoropyridin-2-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(5-fluoropyridin-2-yl)-7-(tetrahydro-2H-pyran-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(pyridin-2-yl)-7-(tetrahydro-2H-pyran-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-7-benzyl-3-(pyridin-2-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-7-benzyl-3-(pyridin-2-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-7-(4-fluorobenzyl)-3-(pyridin-3-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-7-(4-fluorobenzyl)-3-(pyridin-3-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-7-(4-fluorobenzyl)-3-(3-fluoropyridin-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-7-(4-fluorobenzyl)-3-(3-fluoropyridin-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2-chloro-4-fluorophenyl)-7-(tetrahydro-2H-pyran-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2-chloro-4-fluorophenyl)-7-((6-fluoropyridin-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2,4-difluorophenyl)-7-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2,4-difluorophenyl)-7-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-4,5a,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2-chloro-4-fluorophenyl)-7-((tetrahydro-2H-pyran-4-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2-chloro-4-fluorophenyl)-7-((tetrahydro-2H-pyran-4-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2,4-dichlorophenyl)-7-((tetrahydro-2H-pyran-4-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2,4-dichlorophenyl)-7-((tetrahydro-2H-pyran-4-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2,4-dichlorophenyl)-7-(tetrahydro-2H-pyran-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2-chloro-4-fluorophenyl)-7-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2-chloro-4-fluorophenyl)-7-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2-chloro-4-fluorophenyl)-7-((6-methoxypyridin-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2-chloro-4-fluorophenyl)-7-((6-methoxypyridin-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2,4-difluorophenyl)-7-((6-methoxypyridin-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2,4-difluorophenyl)-7-((6-methoxypyridin-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2,4-dichlorophenyl)-7-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2,4-dichlorophenyl)-7-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2-chloro-4-(trifluoromethyl)phenyl)-7-(tetrahydro-2H-pyran-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2,4-dichlorophenyl)-7-(((S)-tetrahydrofuran-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2,4-dichlorophenyl)-7-(((R)-tetrahydrofuran-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2,4-dichlorophenyl)-7-(((R)-tetrahydrofuran-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2,4-dichlorophenyl)-7-(((S)-tetrahydrofuran-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2,4-difluorophenyl)-7-((2-methylfuran-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2,4-difluorophenyl)-7-((2-methylfuran-3-yl)methyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-3-(2,4-difluorophenyl)-7-(furan-3-ylmethyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-3-(2,4-difluorophenyl)-7-(furan-3-ylmethyl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-7-(4-fluorobenzyl)-3-(tetrahydro-2H-pyran-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aS,8aS)-7-(4-fluorobenzyl)-3-(tetrahydro-2H-pyran-4-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine hydrochloride

(5aR,8aR)-7-(4-fluorobenzyl)-3-(1-methyl-1H-pyrazol-5-yl)-4,5a,6,7,8,8a-hexahydropyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,2,3]oxazine hydrochloride, and

pharmaceutically acceptable salts, solvates and prodrugs thereof.

8. A method of treatment and/or prophylaxis of a patient suffering from a sigma receptor mediated disease or condition selected from the group consisting of pain, diarrhea, lipoprotein disorders, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, obesity, migraine, arthritis, hypertension, arrhythmia, ulcer, glaucoma, learning, memory and attention deficits, demyelinating diseases, addiction to drugs and chemical substances, tardive dyskinesia, ischemic stroke, epilepsy, stroke, and stress, the method comprising administering to the patient in need of such a treatment a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof.

9. The method of claim 8 , wherein the disease or condition is pain.

10. The method of claim 8 , wherein the disease or condition is selected from the group consisting of addiction to cocaine, addiction to amphetamine, addiction to ethanol and addiction to nicotine.

11. A process for the preparation of a compound of formula (Ia):

comprising a reaction between a compound of general formula (VI):

with an aldehyde of general formula (VII):

wherein R 2 is as defined in claim 1 and R 1 ′ is selected from is selected from:

a —(C(R 3 ) 2 ) m -aryl group in which the aryl group may be optionally substituted by at least one halogen atom;

a —(C(R 3 ) 2 ) m -heteroaryl group in which the heteroaryl group may be optionally substituted by at least one substituent selected from a halogen, C 1-3 -alkyl, C 1-3 -alkoxy, C 1-3 -haloalkoxy or C 1-3 -haloalkyl and in which the heteroaryl group may optionally be condensed with an additional ring system;

a —(C(R 3 ) 2 ) n -heterocycloalkyl group, in which the heterocycloalkyl group may be optionally substituted by at least one substituent selected from a halogen, C 1-3 -alkyl, C 1-3 -alkoxy, C 1-3 -haloalkoxy or C 1-3 -haloalkyl and contains at least one oxygen atom;

wherein R 3 is H or C 1-3 alkyl;

m is 1 to 2; and

n is 0 to 2;

with the proviso that when R 1 is a —(C(R 3 ) 2 ) m -aryl group, R 2 is not a phenyl group.

12. A process for the preparation of a compound of formula (Ia):

comprising a reduction of a compound of general formula (IX):

wherein R 2 is as defined in claim 1 and R 1 ′ is selected from is selected from:

a —(C(R 3 ) 2 ) m -aryl group in which the aryl group may be optionally substituted by at least one halogen atom;

a —(C(R 3 ) 2 ) m -heteroaryl group in which the heteroaryl group may be optionally substituted by at least one substituent selected from a halogen, C 1-3 -alkyl, C 1-3 -alkoxy, C 1-3 -haloalkoxy or C 1-3 -haloalkyl and in which the heteroaryl group may optionally be condensed with an additional ring system;

a —(C(R 3 ) 2 ) n -heterocycloalkyl group, in which the heterocycloalkyl group may be optionally substituted by at least one substituent selected from a halogen, C 1-3 -alkyl, C 1-3 -alkoxy, C 1-3 -haloalkoxy or C 1-3 -haloalkyl and contains at least one oxygen atom;

being R 3 is H or C 1-3 alkyl;

m is 1 to 2; and

n is 0 to 2;

with the proviso that when R 1 is a —(C(R 3 ) 2 ) m -aryl group, R 2 is not a phenyl group.

13. A process for the preparation of a compound of general formula (I):

comprising a reaction between a compound of general formula (VI):

with an ketone of general formula (Vila):

O═R 1    (VIIa)

wherein R 1 represents a —(C(R 3 ) 2 ) n -heterocycloalkyl group, in which the heterocycloalkyl group may be optionally substituted by at least one substituent selected from a halogen, C 1-3 -alkyl, C 1-3 -alkoxy, C 1-3 -haloalkoxy or C 1-3 -haloalkyl and contains at least one oxygen atom, and n=0.

14. A pharmaceutical composition comprising at least one compound of claim 1 , pharmaceutically acceptable salts, prodrugs, isomers or solvates thereof, and at least a pharmaceutically acceptable carrier, additive, adjuvant or vehicle.

15. The method of claim 9 , wherein the pain is selected from the group consisting of neuropathic pain, inflammatory pain, and pain conditions involving allodynia and/or hyperalgesia.