Medical devices having activated surfaces
Implantable biocompatible polymeric medical devices include a substrate with an acid or base-modified surface which is subsequently modified to include click reactive members.
1. A method of preparing a medical device having an activated surface, the method comprising:
acid-treating at least a portion of a surface of a polymeric medical device to obtain hydrolysis; and
attaching one or more click reactive members to the acid-treated surface of the medical device, wherein the click reactive members are selected from the group consisting of thiols, azides, alkynes, and alkenes.
2. The method according to claim 1 , wherein the acid is selected from the group consisting of HCl, HCl 3 , HCl 4 , H 2 SO 3 , H 2 SO 4 , H 3 PO 4 , HI, HIO 3 , HBr, lactic acid and glycolic acid.
3. The method according to claim 1 , wherein the click reactive member is selected from the group consisting of thiols and alkenes.
4. The method according to claim 1 , wherein the click reactive members are selected from the group consisting of azides and alkynes.
5. The method according to claim 1 , wherein the medical device is selected from the group consisting of monofilament sutures, multifilament sutures, surgical meshes, ligatures, sutures, staples, slings, patches, foams, pellicles, films, barriers, stents, catheters, and inflatable balloons.
6. The method according to claim 1 , wherein the medical device is a surgical mesh.
7. The method according to claim 1 , wherein the medical device comprises a biodegradable polymer selected from collagen, cellulose, poly (amino acids), polysaccharides, hyaluronic acid, copolymers and combinations thereof.
8. The method according to claim 1 , wherein the medical device comprises a non-degradable polymer selected from fluorinated polymers, polyolefins, polyamides, polyurethanes, silicones, polyaryletherketone, copolymers and combinations thereof.
9. The method according to claim 1 , wherein acid-treating at least a portion of a surface of a medical device is conducted at a temperature between 0° C. and a glass transition temperature of a material of the medical device.
10. The method according to claim 1 , wherein the medical device comprises polybutester.
11. The method according to claim 1 , wherein the medical device comprises nylon.
12. The method according to claim 1 , wherein the medical device comprises ultra high molecular weight polyethylene.