Sequences associated with TDP-43 proteinopathies and methods of using the same
The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a TDP-43 proteinopathy. The invention also provides for an array comprising the nucleic acids and peptides of the invention.
1. A nucleic acid comprising at least fifteen contiguous nucleotides to 1000 contiguous nucleotides, including nucleotide 1077, of SEQ ID NO: 1 or SEQ ID NO:3, wherein the nucleic acid is detectably labeled with a fluorescent, chemiluminescent, radioactive, colorimetric, and/or resonance label.
2. The nucleic acid of claim 1 , comprising at least twenty contiguous nucleotides, including nucleotide 1077, of SEQ ID NO: 1 or SEQ ID NO:3.
3. An array comprising a substrate, wherein the substrate comprises a nucleic acid according to claim 1 .
4. The nucleic acid of claim 1 , wherein the nucleic acid hybridizes to a nucleic acid comprising exon 6 of the TDP-43 gene.
5. The array of claim 3 , wherein the substrate is planar.
6. The array of claim 3 , wherein the substrate is a bead.
7. The array of claim 3 , wherein the substrate is the inner surface of a tube for flow-through sample analysis.
8. The nucleic acid of claim 1 , wherein the nucleic acid is isolated.
9. The nucleic acid of claim 1 , wherein the nucleic acid comprises between 20 nucleotides and 1000 contiguous nucleotides, including nucleotide 1077, of SEQ ID NO:1.
10. The nucleic acid of claim 1 , wherein the nucleic acid comprises between 25 nucleotides and 1000 contiguous nucleotides. including nucleotide 1077, of SEQ ID NO:1.
11. The nucleic acid of claim 1 , wherein the nucleic acid comprises between 15 contiguous nucleotides and 500 contiguous nucleotides, including nucleotide 1077, of SEQ ID NO: 1.
12. The nucleic acid of claim 1 , wherein the nucleic acid comprises between 15 contiguous nucleotides and 200 contiguous nucleotides, including nucleotide 1077, of SEQ ID NO: 1.
13. The nucleic acid of claim 1 , wherein the nucleic acid comprises between 15 contiguous nucleotides and 100 contiguous nucleotides, including nucleotide 1077, of SEQ ID NO: 1.
14. The nucleic acid of claim 1 , wherein the nucleic acid comprises between 15 contiguous nucleotides and 50 contiguous nucleotides, including nucleotide 1077, of SEQ ID NO: 1.