Microneedles with sharpened tips and corresponding method of fabrication
Microneedles with sharpened tips are fabricated without any reduction to the shaft diameter below the tip. By sharpening the tip and not the entire length of the microneedle, their mechanical strength is maintained. The microneedles are fabricated out of a wafer substrate using lithography and deep reactive-ion etching (DRIE). By controlling the timing of the DRIE as the photoresist depletes, the sharpness and angle of the tips are controlled.
1. A method for fabricating a microneedle having a sharpened sidewall tip, comprising the steps of:
providing a wafer substrate;
applying a first layer of photoresist to a backside of the wafer substrate using lithography, the first layer of photoresist on the backside of the wafer substrate having a pattern outlining a channel for fluid delivery;
etching a fluid delivery channel into the backside of the wafer substrate using deer reactive-ion etching (DRIE);
applying a second layer of photoresist to a front side of the wafer substrate using lithography, the second layer of photoresist on the front side of the wafer substrate having a pattern outlining a needle for fluid delivery;
etching an extruding needle into the front side of the wafer substrate using DRIE, the fluid delivery channel and the extruding needle forming a passage there through; and
sharpening an upper tip of the extruding needle by using DRIE to deplete the second layer of photoresist and etch sidewalls of the extruding needle, whereby as the second layer of photoresist depletes on the front side of the wafer substrate, a tapered etch profile at the upper tip of the extruding needle is created.
2. A method for fabricating a microneedle having a sharpened sidewall tip as in claim 1 , further comprising the step of:
controlling the taper angle of the upper tip of the extruding needle by varying etch selectivity.
3. A method for fabricating a microneedle having a sharpened sidewall tip as in claim 1 , further comprising the step of:
applying a solvent to remove any residual photoresist.
4. A method for fabricating a microneedle having a sharpened sidewall tip as in claim 1 , further comprising the step of:
forming the wafer substrate of silicon.
5. A method for fabricating a microneedle having a sharpened sidewall tip as in claim 1 , further comprising the step of:
forming the photoresist on the backside of the wafer substrate in an annular pattern outlining a channel for fluid delivery.
6. A method for fabricating a microneedle having a sharpened sidewall tip as in claim 1 , further comprising the step of:
forming the fluid delivery channel within the backside of the wafer substrate in an annular configuration.
7. A method for fabricating a microneedle having a sharpened sidewall tip as in claim 1 , further comprising the step of:
forming the photoresist on the front side of the wafer substrate in an annular pattern outlining a needle for fluid delivery.
8. A method for fabricating a microneedle having a sharpened sidewall tip as in claim 1 , further comprising the step of:
forming the extruding needle on the front side of the wafer substrate in an annular configuration.
9. A method for fabricating a microneedle having a sharpened sidewall tip, comprising the steps of:
providing a wafer substrate;
applying a first photoresist layer to a backside of the wafer substrate using lithography, the first photoresist layer having a pattern outlining a channel for fluid delivery;
etching a fluid delivery channel into the backside of the wafer substrate using deep reactive-ion etching (DRIE);
applying a second photoresist layer to a front side of the wafer substrate using lithography, the second photoresist layer having a pattern outlining a needle for fluid delivery;
etching the second photoresist layer using DRIE to create a microneedle on the front side of the wafer substrate, the fluid delivery channel being disposed within the microneedle; and
gradually depleting the second photoresist layer to create a tapered etch profile at the upper tip of the microneedle using DRIE.
10. A method for fabricating a microneedle having a sharpened sidewall tip as in claim 1 , further comprising the step of:
controlling the taper angle of the upper tip of the microneedle by varying etch selectivity.
11. A method for fabricating a microneedle having a sharpened sidewall tip as in claim 1 , further comprising the step of:
applying a solvent to remove any residual photoresist.
12. A method for fabricating a microneedle having a sharpened sidewall tip as in claim 1 , further comprising the step of:
forming the wafer substrate of silicon.
13. A method for fabricating a microneedle having a sharpened sidewall tip as in claim 1 , further comprising the step of:
forming the photoresist on the backside of the wafer substrate in an annular pattern outlining a channel for fluid delivery.
14. A method for fabricating a microneedle having a sharpened sidewall tip as in claim 1 , further comprising the step of:
forming the fluid delivery channel within the backside of the wafer substrate in an annular configuration.
15. A method for fabricating a microneedle having a sharpened sidewall tip as in claim 1 , further comprising the step of:
forming the photoresist on the front side of the wafer substrate in an annular pattern outlining a needle for fluid delivery.
16. A method for fabricating a microneedle having a sharpened sidewall tip as in claim 1 , further comprising the step of:
forming the extruding needle on the front side of the wafer substrate in an annular configuration.