Germ cell ablation compounds and uses thereof

1. A method of sterilizing fish comprising: contacting an embryonic fish with a compound of formula (I):

wherein

n is 0;

R 1 is hydrogen or a substituted or unsubstituted, branched or unbranched C 1 -C 8 alkyl, or R 1 is a linker to a solid support;

R 2 is hydrogen or a substituted or unsubstituted, branched or unbranched C 1 -C 8 alkyl; and

R 3 is hydrogen, a substituted or unsubstituted aryl, or a substituted or unsubstituted alkylheteroaryl,

with the provisos that:

(i) when n is 0, R 1 is ethyl and R 2 is ethyl, then R 3 is not 5-methylisoxazol-3-yl;

(ii) when n is 0, R 1 is ethyl and R 2 is ethyl, then R 3 is not 1-phenylehtyl;

(iii) when n is 0, R 1 is ethyl and R 2 is ethyl, then R 3 is not 4-(N-hydroxynitrosyl)phenyl;

(iv) when n is 0, R 1 is ethyl and R 2 is H, then R 3 is not 4-(N,N-dimethylcarbamoyl)phenyl;

(v) when n is 0, R 1 is ethyl and R 2 is H, then R 3 is not 4-carbamoylphenyl; and

(vi) when n is 0, R 1 is propyl and R 2 is H, then R 3 is not 1-phenylethyl;

wherein said contacting begins prior to 4 hours post fertilization and wherein said contacting leads to sterilization of the fish upon developing into an adult.

2. The method of claim 1 , wherein the compound of Formula (I) is primordazine having the structure:

3. A fish embryo obtained by the method of claim 1 .

4. The method of claim 1 , wherein R 1 is C 1 -C 4 alkyl.

5. The method of claim 4 , wherein R 1 is methyl, ethyl, propyl or n-butyl.

6. The method of claim 1 , wherein R 2 is hydrogen or C 1 -C 4 alkyl.

7. The method of claim 6 , wherein R 2 is hydrogen or ethyl.

8. The method of claim 1 , wherein R 3 is an unsubstituted phenyl or a substituted phenyl.

9. The method of claim 8 , wherein R 3 is a phenyl substituted with acetyl or a halogen.

10. The method of claim 1 , wherein R 3 is furanylmethyl.

11. The method of claim 1 , wherein the compound of Formula (I) is selected from the group consisting of: