Therapeutic drug for hypertension or prehypertension
The present invention relates to a therapeutic drug or a preventive drug for hypertension or high-normal blood pressure, comprising (a) and (b) as active ingredients: (a) a 2-phenylthiazole compound represented by formula (I) or a pharmaceutically acceptable salt thereof; (b) at least one compound or a pharmaceutically acceptable salt thereof selected from the group consisting of calcium antagonists, renin-angiotensin system inhibitors, diuretics, sympatholytic agents, vasodilators, and medicinally acceptable salts of these. The present invention also relates to a therapeutic method or a preventive method for hypertension or high-normal blood pressure, comprising administering the above (a) and (b) in amounts effective for treating or preventing hypertension or high-normal blood pressure.
1. A therapeutic method for hypertension or high-normal blood pressure comprising administering (a) and (b) in an amount which is more effective than an additive effect for the therapy of hypertension or high-normal blood pressure to a patient in need thereof:
(a) 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazole carboxylic acid or a pharmaceutically acceptable salt thereof,
(b) losartan, candesartan, valsartan, telmisartan, olmesartan, irbesartan, pratosartan, eprosartan or a pharmaceutically acceptable salt thereof.
2. The therapeutic method for hypertension or high-normal blood pressure according to claim 1 , wherein (b) is losartan or candesartan.
3. The therapeutic method for hypertension or high-normal blood pressure according to claim 1 , wherein (a) and (b) are administered simultaneously.
4. The therapeutic method for hypertension or high-normal blood pressure according claim 1 , wherein (a) and (b) are administered separately.