Heterocyclic compounds and uses thereof

1. A compound of Formula (I):

or an enantiomer, a mixture of enantiomers, or a mixture of two or more diastereomers thereof, or a pharmaceutically acceptable form thereof, wherein

W b 1 and W b 2 are each independently CR 6 , S, O, N or NR 14 , wherein at least one of W b 1 and W b 2 is CR 6 , N or NR 14 ;

W b 5 is CR 8 , CHR 8 , or N;

p is 1;

B is hydrogen, alkenyl, alkynyl, amino, heteroalkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, each of which is substituted with 0-4 R 2 ;

each R 2 is independently alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxyl, nitro, phosphate, urea or carbonate;

X is absent or is (CH(R 9 )) z —;

Y is absent, —O—, —S—, —S(═O)—, —S(═O) 2 —, —N(R 9 )—, —C(═O)—(CHR 9 ) z —, —C(═O)—, —N(R 9 )—C(═O)NH—, or —N(R 9 )C(R 9 ) 2 —;

each z is independently an integer of 1, 2, 3, or 4;

R 3 is a 6-membered heteroaryl or 6-membered heterocyclyl; wherein each of the above substituents is substituted with 0, 1, 2, or 3 R 13 ;

each R 6 is independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, fluoroalkyl, heteroalkyl, alkoxy, amido, amino, acyl, acyloxy, sulfinyl, sulfonyl, sulfoxide, sulfone, sulfonamido, halo, cyano, heteroaryl, aryl, hydroxyl, or nitro;

R 8 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heteroalkyl, alkoxy, amino, acyl, acyloxy, sulfonamido, halo, cyano, hydroxyl, or nitro;

each R 9 is independently hydrogen, alkyl, cycloalkyl, heterocyclyl or heteroalkyl;

W d is

A is N or CR 19 ;

R 10 , R 11 , R 12 , R 13 , and R 19 are independently hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocyclyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, haloalkyl, cyano, hydroxyl, nitro, phosphate, urea, carbonate, oxo, or NR′R″ wherein R′ and R″ are taken together with nitrogen to form a cyclic moiety; and

each R 14 is independently hydrogen, alkyl, cycloalkyl, heterocyclyl or heteroalkyl.

2. The compound of claim 1 , wherein the compound of Formula (I) has a structure of Formula (II):

3. The compound of claim 2 , wherein the compound of Formula (I) has a structure of Formula (IIb):

4. The compound of claim 2 , wherein the compound of Formula (I) has a structure of Formula (III):

5. The compound of claim 4 , wherein the compound of Formula (I) has a structure of Formula (IIIb-1):

6. The compound of claim 5 , wherein R 3 is a 6-membered heteroaryl substituted with 1 R 13 , B is aryl, R 8 is hydrogen, R 9 is alkyl, and R 10 , R 11 , and R 12 are independently hydrogen, amino, and cyano.

7. The compound of claim 6 , wherein R 3 is pyridyl substituted with alkoxy.

8. The compound of claim 6 , wherein B is phenyl substituted with 0 occurrences of R 2 .

9. The compound of claim 6 , wherein R 9 is methyl.

10. The compound of claim 6 , wherein R 10 is amino, R 11 is cyano, and R 12 is hydrogen.

11. The compound of claim 1 , wherein R 3 is 6-membered heteroaryl substituted with 1, 2 or 3 R 13 .

12. The compound of claim 1 , wherein R 3 is pyridyl substituted with 1, 2 or 3 R 13 .

13. The compound of claim 1 , wherein A is N.

14. The compound of claim 1 , wherein W d is:

15. The compound of claim 14 , wherein W d is

16. The compound of claim 1 , wherein B is heteroalkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, each of which is substituted with 0-4 R 2 .

17. The compound of claim 16 , wherein B is aryl substituted with 0-4 occurrences of R 2 .

18. The compound of claim 17 , wherein B is phenyl substituted with 0 occurrences of R 2 .

19. The compound of claim 1 , wherein R 8 is hydrogen.

20. The compound of claim 1 , wherein R 9 is methyl.

21. The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable form thereof.

22. A pharmaceutical composition comprising a compound according to claim 1 and one or more pharmaceutically acceptable excipients.

23. A compound of Formula (I):

or an enantiomer, a mixture of enantiomers, or a mixture of two or more diastereomers thereof, or a pharmaceutically acceptable form thereof, wherein

W b 1 and W b 2 are each independently CR 6 , S, O, N or NR 14 , wherein at least one of W b 1 and W b 2 is CR 6 , N or NR 14 ;

W b 5 is CR 8 , CHR 8 , or N;

p is 1;

B is hydrogen, alkyl, alkenyl, alkynyl, amino, heteroalkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, each of which is substituted with 0-4 R 2 ;

each R 2 is independently alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxyl, nitro, phosphate, urea or carbonate;

X is absent or is (CH(R 9 )) z —;

Y is absent, —O—, —S—, —S(═O)—, —S(═O) 2 —, —N(R 9 )—, —C(═O)—(CHR 9 ) z —, —C(═O)—, —N(R 9 )—C(═O)NH—, or —N(R 9 )C(R 9 ) 2 —;

each z is independently an integer of 1, 2, 3, or 4;

R 3 is aryl, 9-membered heteroaryl, or 10-membered heteroaryl, or R 3 is a heteroatom selected from N, S, and O, wherein the heteroatom has a covalent bond, either directly or through a C 1 -C 6 alkyl group, to an aryl, heteroaryl or heterocyclyl, wherein each of the above substituents is substituted with 0, 1, 2, or 3 R 13 ;

each R 6 is independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, fluoroalkyl, heteroalkyl, alkoxy, amido, amino, acyl, acyloxy, sulfinyl, sulfonyl, sulfoxide, sulfone, sulfonamido, halo, cyano, heteroaryl, aryl, hydroxyl, or nitro;

R 8 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heteroalkyl, alkoxy, amino, acyl, acyloxy, sulfonamido, halo, cyano, hydroxyl, or nitro;

each R 9 is independently hydrogen, alkyl, cycloalkyl, heterocyclyl or heteroalkyl;

W d is

A is N or CR 19 ;

R 10 , R 11 , R 12 , R 13 , and R 19 are independently hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocyclyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, haloalkyl, cyano, hydroxyl, nitro, phosphate, urea, carbonate, oxo, or NR′R″ wherein R′ and R″ are taken together with nitrogen to form a cyclic moiety; and

each R 14 is independently hydrogen, alkyl, cycloalkyl, heterocyclyl or heteroalkyl.

24. The compound of claim 23 , wherein the compound of Formula (I) has a structure of Formula (IIb):

25. The compound of claim 23 , wherein R 3 is a fused 5/6-bicyclic heteroaryl or fused 6/6-bicyclic heteroaryl, wherein each of the above substituents is substituted with 0, 1, 2, or 3 R 13 .

26. The compound of claim 23 , wherein the compound is:

or a pharmaceutically acceptable form thereof.

27. A pharmaceutical composition comprising a compound according to claim 23 and one or more pharmaceutically acceptable excipients.

28. A compound of Formula (I):

or an enantiomer, a mixture of enantiomers, or a mixture of two or more diastereomers thereof, or a pharmaceutically acceptable form thereof, wherein

W b 1 and W b 2 are each independently CR 6 , S, O, N or NR 14 , wherein at least one of W b 1 and W b 2 is CR 6 , N or NR 14 ;

W b 5 is CR 8 , CHR 8 , or N;

p is 1;

B is hydrogen, alkyl, alkenyl, alkynyl, amino, heteroalkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, each of which is substituted with 0-4 R 2 ;

each R 2 is independently alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxyl, nitro, phosphate, urea or carbonate;

X is absent or is —(CH(R 9 )) z —;

Y is absent, —O—, —S—, —S(═O)—, —S(═O) 2 —, —N(R 9 )—, —C(═O)—(CHR 9 ) z —, —C(═O)—, —N(R 9 )—C(═O)NH—, or —N(R 9 )C(R 9 ) 2 —;

each z is independently an integer of 1, 2, 3, or 4;

R 3 is 5-membered heteroaryl or 5-membered heterocyclyl, wherein each of the above substituents is substituted with 0, 1, 2, or 3 R 13 ;

each R 6 is independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, fluoroalkyl, heteroalkyl, alkoxy, amido, amino, acyl, acyloxy, sulfinyl, sulfonyl, sulfoxide, sulfone, sulfonamido, halo, cyano, heteroaryl, aryl, hydroxyl, or nitro;

R 8 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heteroalkyl, alkoxy, amino, acyl, acyloxy, sulfonamido, halo, cyano, hydroxyl, or nitro;

each R 9 is independently hydrogen, alkyl, cycloalkyl, heterocyclyl or heteroalkyl;

W d is

A is N or CR 19 ;

R 10 , R 11 , R 12 , R 13 , and R 19 are independently hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocyclyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, haloalkyl, cyano, hydroxyl, nitro, phosphate, urea, carbonate, oxo, or NR′R″ wherein R′ and R″ are taken together with nitrogen to form a cyclic moiety; and

each R 14 is independently hydrogen, alkyl, cycloalkyl, heterocyclyl or heteroalkyl, and

wherein the compound of Formula (I) is not one of the following compounds:

29. The compound of claim 28 , wherein the compound is: