Aminosteroids for the treatment of a PTP1B associated disease
This application is directed to the use of aminosteroid compounds for the selective inhibition of the enzyme PTP1B in a mammal for the treatment of diabetes.
1. A compound or pharmaceutically acceptable salt thereof selected from the group consisting of:
2. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable diluent or carrier.
3. The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein the compound is
4. The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein the compound is
5. A pharmaceutical composition comprising the compound of claim 3 and a pharmaceutically acceptable diluent or carrier.
6. A pharmaceutical composition comprising the compound of claim 4 and a pharmaceutically acceptable diluent or carrier.
7. The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein the compound is
8. The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein the compound is
9. A pharmaceutical composition comprising the compound of claim 7 and a pharmaceutically acceptable diluent or carrier.
10. A pharmaceutical composition comprising the compound of claim 8 and a pharmaceutically acceptable diluent or carrier.