Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling
The present invention provides cyclic-di-nucleotide (CDN) compounds that inhibit signaling at a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides which inhibit STING-dependent TBK1 activation and the resulting production of type I interferon.
1. A composition comprising a cyclic dinucleotide selected from the group consisting of:
wherein R 1 is H and R 2 is propargyl, or wherein R 1 is propargyl and R 2 is H.
2. A method of inhibiting STING-dependent type I Interferon production in an individual in need thereof, comprising:
administering a composition according to claim 1 to the individual in an amount sufficient to inhibit STING-dependent type I Interferon production.
3. A method according to claim 2 , wherein the administration is parenteral.
4. A method according to claim 3 , wherein the administration is subcutaneous, intramuscular, or intradermal.